Protein

Protein accession
A0AAX4NC08 [UniProt]
Representative
2snIK
Source
UniProt (cluster: phalp2_32792)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MGRLTTAARTSVVALVLSAAGIGFLQTEEGHSDRVYLDSIGKPTVCTGHMDAKMKVGTYYSPEQCDQLLREDTGSAAYAVRQLVKVPLYQYEFDALVSFCFNVGNANCRSATLFKVLNNGDYTAVPYQLSRWRFAGGLDCKVRSNNCYGVYLRRQHEGDLWRNGYK
Physico‐chemical
properties
protein length:166 AA
molecular weight:18528,8 Da
isoelectric point:8,73
hydropathy:-0,26
Representative Protein Details
Accession
2snIK
Protein name
2snIK
Sequence length
206 AA
Molecular weight
21840,85610 Da
Isoelectric point
9,36979
Sequence
MFKKILAAAGLGLAGYVAYSAYAENRGVSANGEGGLMDIAAGVIEGGFMKVTSFNGGLNMGISLAGLAHIKGWEGFRVNRYLDSAGKPTIGYGHLILPTESYQTITIEEATRLLVKDLSAAEDAVNSLVKIKLSQFQFDALVSFVFNVGRGAFARSTLLKKVNAGLFTEAKAEFLKWVNSGGKFTQGLYNRRVADAELFAAGGKVA
Other Proteins in cluster: phalp2_32792
Total (incl. this protein): 45 Avg length: 166,0 Avg pI: 8,88
Protein ID Length (AA) pI
2snIK 206 9,36979
14vQj 154 8,96596
1CxvC 151 9,11726
1Mbjw 210 9,07426
1faPP 154 9,80463
1farj 155 9,75782
1j4hc 193 9,88347
1lalN 171 5,91844
1qljN 151 8,85327
27Ccx 151 8,96596
2GP9z 151 9,44689
2KnGP 151 9,11701
2Q0Md 151 8,90503
2RUji 163 9,41956
2RZ0s 153 9,72958
2pWyl 151 9,65409
2snIY 207 9,34645
33RaN 153 9,28669
3cMjI 137 4,33849
3dJ2D 154 9,82480
4YFHs 151 9,30029
4zkYi 154 7,05494
52mqU 151 9,11726
5AYk0 151 9,33974
5Hn8v 154 9,78864
5HnGm 154 9,67846
5JbWx 154 9,82480
5Jf7u 154 9,72849
5Jfa9 109 9,22963
5sux8 154 9,81159
5zGxD 146 9,82590
6L4oq 154 9,46952
6PoMa 154 6,74647
6W7qw 154 9,78864
7sDye 220 10,05212
7vkhy 206 10,43255
89wiG 151 9,07820
8auMr 154 9,85588
98g4 235 5,01459
98it 236 5,00271
9ae2 237 5,61014
Pfm9 151 9,76517
dGcu 203 9,36985
eysJ 149 9,39254
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_28113
7zmZV
 50 52,0% 146 1.870E-61
2 phalp2_2632
6RhYr
 14867 56,8% 139 2.320E-60
3 phalp2_33221
5jbqV
 447 54,6% 141 1.534E-59
4 phalp2_4451
31DIk
 4919 54,0% 148 2.605E-58
5 phalp2_6830
8n5Jv
 121 51,6% 149 1.558E-56
6 phalp2_2498
5GMvl
 297 49,2% 140 2.391E-54
7 phalp2_126
5jCCA
 637 54,0% 148 6.144E-54
8 phalp2_10624
2nrBp
 12 52,4% 145 1.766E-51
9 phalp2_34911
4lF8s
 21 46,5% 144 2.185E-50
10 phalp2_17663
6R9yG
 6 45,3% 150 1.781E-48

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 2snIK (206 AA)
Member sequence: A0AAX4NC08 (166 AA)
1 206 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Pseudomonas phage vB_PpuP-Luke-3
[NCBI] 		3132676 Autographiviridae > Pollyceevirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
PP496472 [NCBI]
CDS location
range 39175 -> 39675
strand +
CDS
ATGGGCCGTCTAACCACGGCGGCTCGTACTTCCGTTGTTGCTCTCGTGCTGTCAGCCGCTGGGATTGGGTTCCTTCAAACCGAAGAAGGGCACTCCGACCGCGTGTATCTGGACAGCATCGGGAAGCCTACGGTCTGTACCGGGCACATGGACGCCAAGATGAAGGTCGGGACGTACTACTCGCCAGAGCAATGCGACCAACTTCTGCGCGAGGACACCGGGTCTGCTGCCTACGCGGTACGCCAGCTCGTGAAAGTCCCGCTCTACCAATACGAATTCGATGCCCTCGTGAGCTTCTGCTTCAACGTAGGCAACGCGAACTGCCGCTCAGCCACTCTGTTCAAGGTGCTCAACAACGGGGACTACACCGCCGTGCCGTACCAGCTCTCCCGCTGGCGCTTCGCTGGTGGTCTGGACTGCAAAGTGCGCTCGAACAACTGCTACGGCGTGTACCTGCGGCGTCAGCACGAGGGTGACCTCTGGAGGAACGGGTACAAGTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (2snIK) rather than this protein.
PDB ID
2snIK
Method AlphaFoldv2
Resolution 78.32
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50