Protein

Protein accession
A0AAX4NA24 [UniProt]
Representative
83EoO
Source
UniProt (cluster: phalp2_26525)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKIPTSTKLKAIALAVTMLVGVEGLSTKAYKDTGGVWTICYGETKGVTQGMTATKQQCWTMLQSEAEATLVAIAPYLPATLNPNQYAALVSFCYNVGVYNCKTSTMFKYINKGDYVAAQKEFGRWIYVKKADCRLAASNCSGIPKRRAAEATLWAKPST
Physico‐chemical
properties
protein length:159 AA
molecular weight:17314,0 Da
isoelectric point:9,39
hydropathy:-0,05
Representative Protein Details
Accession
83EoO
Protein name
83EoO
Sequence length
225 AA
Molecular weight
24678,94010 Da
Isoelectric point
6,34502
Sequence
MNPLVKRLSLLGASSVIAVSGAYMVAPWEGKENHAYKDIVGVATICFGETKGVKMGDYRTDEQCEQSLVSELTAYNKAMKKHVKVELKPYEEIAYTSFVWNVGETNFKNSTLLKKLNSGDRVGACNELPRWNKAGGNVVKGLTNRRLHEQKVCLGKDETVNAALSSLSVQQEAPETFISTGQGVGEGEPVSTLTGPLNEPEVSIPDVPPEAPVEKCWKFLWFCLK
Other Proteins in cluster: phalp2_26525
Total (incl. this protein): 66 Avg length: 169,0 Avg pI: 8,79
Protein ID Length (AA) pI
83EoO 225 6,34502
1bubJ 154 9,27424
3MfMo 154 8,34790
4o4kW 225 6,34990
76l21 174 9,29720
7A6Zl 156 6,82190
7Z7JB 215 5,88763
7ccno 171 9,50407
7nQlX 156 7,82145
7wSwg 174 9,34916
8ppuj 169 8,57444
B4XY89 160 9,11327
A0A0S4KWN4 183 8,59107
A0A649V3B1 160 9,09663
A0A173GD86 156 9,56442
A0A2H4P869 184 8,59204
A0A2R2YAJ6 191 8,73677
A0A0F6YRF6 160 8,77210
A0A0A1IUR9 160 9,23511
U3PFR1 173 9,78799
A0A0A1IVZ0 156 8,95525
A0A2R4P9D5 160 9,09663
A0A7H0XFU0 187 8,98646
S4SYS9 160 9,09663
A0AAE7V760 163 9,17116
A0AAE8XI77 183 8,55555
A0AAE9BNU3 183 8,24352
A0AAE9GQQ3 183 8,27157
A0A5Q2W989 170 8,96157
A0A915YA02 160 8,94165
A0A975UUP2 184 6,17046
A0AAE8YJJ9 183 8,55555
A0AAE9C9H7 183 8,24352
A0AAF0CZH5 160 8,95525
A0AAU6VYK5 183 6,39037
A0AAU6VZ99 183 6,39037
A0AAX4MV83 184 7,55949
A0AAX4MWR2 174 9,11146
A0AAX4MXX9 174 8,98730
A0AAX4MY14 174 8,97434
A0AAX4MYG5 174 8,97434
A0AAX4MZX8 174 9,11146
A0AAX4N7T9 159 9,39009
A0AAX4N7X4 159 9,39009
A0AAX4N8K3 159 9,39009
A0AAX4N8L5 159 9,39009
A0AAX4N918 159 9,39009
A0AAX4N973 159 9,39009
A0AAX4N9E0 159 9,39009
A0AAX4N9G8 159 9,39009
A0AAX4N9X6 159 9,39009
A0AAX4NA07 159 9,47332
A0AAX4NA73 159 9,39009
A0AAX4NA78 159 9,39009
A0AAX4NAG2 159 9,39009
A0AAX4NAK3 159 9,39009
A0AAX4NAP1 159 9,39009
A0AAX4NAQ8 159 9,39009
A0AAX4NAR8 159 9,39009
A0AAX4NB04 159 9,39009
A0AAX4NB62 159 9,39009
A0AAX4NBC3 159 9,39009
A0AAX4NBQ2 159 9,39009
A0AAX4NBX4 159 9,39009
A0AAX4NBX7 159 9,39009
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_4305
8aoFg
 2477 45,5% 156 2.475E-59
2 phalp2_15038
7cXTn
 20 44,4% 153 3.423E-53
3 phalp2_30973
1fTML
 10 40,0% 145 1.201E-49
4 phalp2_2632
6RhYr
 14867 45,2% 137 1.479E-48
5 phalp2_8252
7B99h
 46 42,2% 149 8.641E-44
6 phalp2_33221
5jbqV
 447 38,1% 139 1.983E-42
7 phalp2_21319
1KsyR
 184 37,7% 159 4.544E-41
8 phalp2_33109
4K52y
 18 35,7% 168 2.659E-39
9 phalp2_22286
7A6Fj
 714 32,0% 187 3.636E-39
10 phalp2_2498
5GMvl
 297 39,0% 141 6.798E-39

Domains

Domains [InterPro]
GH24
Disordered region
Representative sequence (used for alignment): 83EoO (225 AA)
Member sequence: A0AAX4NA24 (159 AA)
1 225 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Pseudomonas phage vB_PpuP-Mora-5
[NCBI] 		3132668 Autographiviridae >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
PP496464 [NCBI]
CDS location
range 41024 -> 41503
strand +
CDS
ATGAAGATCCCAACCAGCACCAAGCTGAAAGCCATCGCGCTAGCAGTTACCATGCTGGTTGGGGTTGAGGGACTGAGCACCAAGGCGTATAAGGATACGGGCGGTGTGTGGACGATCTGCTACGGCGAAACCAAGGGTGTAACACAAGGCATGACTGCTACCAAGCAGCAGTGCTGGACTATGTTACAGTCGGAAGCCGAGGCTACTCTCGTCGCAATCGCTCCATACCTGCCTGCTACCCTTAACCCCAACCAATACGCTGCGCTTGTATCCTTCTGCTATAACGTCGGAGTGTACAACTGCAAGACCTCGACCATGTTCAAGTACATCAACAAAGGCGATTACGTCGCTGCCCAGAAGGAATTCGGGCGTTGGATCTACGTGAAGAAGGCCGACTGCCGCTTAGCAGCTAGCAACTGCTCCGGTATCCCTAAACGACGTGCTGCGGAGGCTACCTTATGGGCCAAACCAAGTACCTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (83EoO) rather than this protein.
PDB ID
83EoO
Method AlphaFoldv2
Resolution 82.00
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50