Protein

Protein accession
A0AAX4GN12 [UniProt]
Representative
6Xyoc
Source
UniProt (cluster: phalp2_8169)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MSLRTKVIAALTGATMLGGAITGVVQHSEGLSLTAYKDSAGVPTICYGETKSVKMGQRATLSDCQKQLIQSAGEHAKALDGLPMQLSDVALVGSVDFIYNVGVAGFNGSAVKRHLKSLNYAAAGKAVLDWRYISKYQQKSPGVGWVYKGGNRWTFDCSQYINGQRNKVCWGLWERRQWQSKAIGNQYKNVNAAVTALTKTGG
Physico‐chemical
properties
protein length:202 AA
molecular weight:21782,7 Da
isoelectric point:9,72
hydropathy:-0,21
Representative Protein Details
Accession
6Xyoc
Protein name
6Xyoc
Sequence length
269 AA
Molecular weight
27996,45290 Da
Isoelectric point
4,90915
Sequence
MTEAPKPSWYLGPRTDATPAASTLTINAAGLAIIETSEGLVLTATQDPTGVWTIGYGHTIGVVQGQQITVDQANALLAQDLAVFESGVGAVAVNPTSNQFSAMVSLAYNIGMGGFNGSTVLRDHNAGNFAGAADAFLMWDKAHVDGQLVVLPGLDVRRAAERALYLTPDSAPAPPPMPPPTEATISVALPTEGTDQSGNKVKLVWSSVAAGIVMLAGGLALSPKPDVAPIARPPLERGMEITIRHGFDFSGSTFTFDQNLRPVPIEKGR
Other Proteins in cluster: phalp2_8169
Total (incl. this protein): 32 Avg length: 205,9 Avg pI: 9,47
Protein ID Length (AA) pI
6Xyoc 269 4,90915
2nben 286 6,44483
A0A1P8VW89 199 9,67131
A0A0H3YIB7 201 9,77046
A0A3G8FJ64 201 9,81494
A0A248SL51 184 9,59504
A0A1B1PEK8 201 9,81494
A0A2U7N914 201 9,81494
A0A385IFZ3 201 9,81494
A0A3G8FGT0 201 9,81494
A0A3G8FH23 201 9,81494
A0A3G8FHD2 201 9,81494
A0A3G8FHM7 201 9,81494
A0A3G8FHZ3 201 9,81494
A0A3G8FI06 201 9,81494
A0A3G8FIK0 201 9,81494
A0A3G8FIT4 201 9,81494
A0A3G8FK32 201 9,81494
A0A3G8FK79 201 9,81494
A0A3G8FKJ0 201 9,81494
A0A3G8FL24 201 9,81494
A0A3G8FLV9 201 9,77046
A0A5J6CU93 184 9,53579
A0A6J5NJK8 255 8,82258
A0AAD2GRL9 200 9,64887
A0AAV1MC72 199 9,64197
A0AAV1MCU2 198 9,74931
A0AAV1MD53 199 9,69645
A0AAX4GVP2 199 9,64855
A0AAX4LR54 199 9,67131
A0AB39C5Q5 199 9,74415
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_26378
1q5mp
 207 53,2% 197 1.367E-52
2 phalp2_29738
1pBjt
 830 47,4% 177 4.554E-41
3 phalp2_10966
4MkR6
 70 48,1% 193 3.302E-36
4 phalp2_8252
7B99h
 46 41,3% 174 2.358E-29
5 phalp2_37362
7p1qj
 436 38,0% 221 8.184E-27
6 phalp2_34307
3A2Hz
 178 38,9% 185 1.513E-26
7 phalp2_15486
82zJS
 6 33,7% 219 2.617E-20
8 phalp2_34268
3g7XB
 9 40,9% 198 2.617E-20
9 phalp2_32973
48mC5
 1 36,2% 193 1.821E-18

Domains

Domains [InterPro]
GH24
Unannotated
Representative sequence (used for alignment): 6Xyoc (269 AA)
Member sequence: A0AAX4GN12 (202 AA)
1 269 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Klebsiella phage RCIP0043
[NCBI] 		3094211 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OR532837 [NCBI]
CDS location
range 3057 -> 3665
strand +
CDS
ATGAGTTTAAGGACTAAGGTTATTGCGGCCCTCACGGGGGCCACTATGCTTGGTGGTGCCATTACCGGGGTGGTTCAGCACAGCGAGGGCCTGAGCCTCACAGCCTACAAGGATAGCGCCGGTGTTCCCACTATCTGCTACGGGGAGACAAAGAGCGTCAAGATGGGTCAGAGAGCCACGCTGAGCGATTGTCAGAAGCAGCTGATACAATCAGCCGGGGAACACGCAAAGGCCCTTGACGGGCTTCCTATGCAGCTCTCTGACGTAGCTCTGGTTGGGTCTGTAGACTTCATTTATAATGTAGGCGTAGCTGGCTTCAACGGTAGTGCCGTGAAGCGCCATCTCAAAAGCCTGAACTACGCAGCGGCTGGGAAGGCTGTGCTGGATTGGCGCTATATTAGCAAGTACCAGCAGAAGTCCCCTGGAGTTGGTTGGGTATATAAGGGCGGCAATCGCTGGACCTTCGACTGTTCCCAATACATTAACGGGCAACGCAATAAGGTGTGCTGGGGCCTGTGGGAGCGTAGGCAGTGGCAGAGCAAGGCCATTGGGAACCAGTATAAGAATGTAAATGCTGCGGTGACAGCTCTCACTAAGACCGGAGGATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (6Xyoc) rather than this protein.
PDB ID
6Xyoc
Method AlphaFoldv2
Resolution 77.33
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50