Protein

Protein accession
A0AAX4G403 [UniProt]
Representative
7skiR
Source
UniProt (cluster: phalp2_10054)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MVKVINKSVCRGVAGKRVGNVKGMVIHNDAGSIGATPESYVTRLQAMTNEQLENGFAHYYINRNTVARVEDTFNKAWHTANADGNANYIGYEVCQSLGASDKDFLANEQATFKQVAEDLKFYGLKANRDTVRLHREFVATACPHRSWELHGKSVNSVKDYFIAQINKYMGVTTPKPPAAVKSPVKHKPPVKPQQIKRVAEKGTFYPNTTVAIKHTPTIKAKQEATLGKGESVIYDSYVKSDGYVWVSYIRNNGKRGYACSRDVKTGKAFGTFK
Physico‐chemical
properties
protein length:273 AA
molecular weight:30316,1 Da
isoelectric point:9,68
hydropathy:-0,53
Representative Protein Details
Accession
7skiR
Protein name
7skiR
Sequence length
482 AA
Molecular weight
54856,31980 Da
Isoelectric point
8,02556
Sequence
MDKNIERIIKVYRATDTPFFLSVVIAQYMIESNNGTSELAKQAHNYFGHKIGENWNGQIYYKDATEEQNGKMVNVGQTAWRKYSTLEECVADHLNWLTQTEWYKNYYADAINAKTYKEQAEVLEGKYATASYYAEAIIDKIEKLKLYEYDQEKGSDQVMGIKKPKRLFADYLHAGYMNPIKGVVIHNDAGSIGGTATFYKGWLRNRDKDLGIAHYYITEEEIGRYINTNEVGWHTANTEGNGHYIGYEVCQSIGASREEFLRNEDMTLRQVAEDMLFYKIPVNRNTVRLHKEFSSTTCPHRSWDLHGQSVNSVKDYWIAKIKHYQSLGKTVDEMIDAENKGVKAPVSKPQAPKSEPKPTIKKAENIFAELKEGQEVTIRKQMTHWFIPDGNGGKKPSISVAGKKDKIKKVISCDKSNSKRAYLLAGFNSWILEQDLEEAYASLTKVEGAPAKQNPTPAVAMVDGEGYVHLNGVKYKVNLTKE
Other Proteins in cluster: phalp2_10054
Total (incl. this protein): 4 Avg length: 319,8 Avg pI: 9,18
Protein ID Length (AA) pI
7skiR 482 8,02556
D7RWK6 273 9,58511
D7RWE7 251 9,43529
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_11372
7BXB0
 3 43,2% 347 3.528E-74
2 phalp2_7784
7lEhL
 1 38,6% 321 4.719E-52
3 phalp2_32385
yZyv
 16 33,4% 377 2.262E-36
4 phalp2_3379
3pnB5
 146 27,2% 338 3.369E-20
5 phalp2_9614
1Eh3E
 1 26,9% 546 5.953E-20
6 phalp2_24803
725t1
 19 28,0% 435 1.798E-18

Domains

Domains [InterPro]
GLUCO
Ami2
Unannotated
Representative sequence (used for alignment): 7skiR (482 AA)
Member sequence: A0AAX4G403 (273 AA)
1 482 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510, PF01832

Taxonomy

  Name Taxonomy ID Lineage
Phage Brochothrix phage BtpYZU03
[NCBI] 		3053259 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OQ863045 [NCBI]
CDS location
range 1 -> 822
strand +
CDS
ATGGTAAAAGTAATTAATAAATCAGTATGCAGAGGCGTCGCAGGCAAACGAGTTGGGAATGTTAAAGGTATGGTAATCCATAATGATGCAGGATCTATTGGTGCAACTCCTGAATCGTACGTCACACGATTACAAGCAATGACTAACGAGCAACTTGAAAACGGCTTTGCGCATTACTATATTAACCGCAACACCGTTGCACGTGTGGAAGATACATTTAATAAAGCATGGCATACAGCTAACGCTGACGGTAATGCTAATTACATCGGTTACGAAGTGTGTCAGTCATTAGGTGCAAGTGATAAAGATTTTCTAGCTAATGAACAAGCAACATTTAAACAAGTTGCTGAAGATCTTAAATTTTATGGCTTGAAAGCTAATCGTGATACAGTACGTTTACATCGTGAGTTTGTAGCAACTGCATGTCCGCATCGTTCTTGGGAATTGCATGGCAAGTCTGTTAACAGCGTTAAAGACTACTTTATTGCACAGATTAATAAGTATATGGGTGTGACAACTCCTAAACCACCTGCAGCAGTCAAATCGCCTGTAAAACATAAGCCGCCAGTTAAACCACAGCAAATTAAGCGTGTGGCTGAAAAAGGCACGTTCTATCCTAATACAACGGTAGCAATCAAACATACGCCCACAATTAAGGCGAAGCAAGAAGCCACGTTAGGTAAAGGCGAGTCAGTTATCTATGACAGCTATGTTAAGTCAGATGGCTATGTTTGGGTATCTTATATTCGAAACAACGGTAAGCGAGGCTATGCGTGTTCTCGTGACGTTAAAACAGGCAAGGCGTTCGGTACGTTTAAATAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0006508 proteolysis biological process None (UniProt)
GO:0008233 peptidase activity molecular function None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7skiR) rather than this protein.
PDB ID
7skiR
Method AlphaFoldv2
Resolution 84.61
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50