Protein

Protein accession
A0AAX4AMV8 [UniProt]
Representative
7ZWXa
Source
UniProt (cluster: phalp2_22738)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MEVSQKGQQALEVMEGFSAKAYLDVAGVPTIGFGDTSVRARKVKMGDTTTLEAAKAELALDLHDFKSGVEKYLVKAVKGTTQNQFDALVIFAYNVGLTNFASSSVLRNHLAGNFEAAAASFALWNKITVNGKKVVSKGLVNRRAKEVEIYLHSNYGV
Physico‐chemical
properties
protein length:157 AA
molecular weight:16960,2 Da
isoelectric point:9,27
hydropathy:-0,04
Representative Protein Details
Accession
7ZWXa
Protein name
7ZWXa
Sequence length
183 AA
Molecular weight
20159,88990 Da
Isoelectric point
9,48912
Sequence
MAKRGRPLSVKLSATAIAASLALQFTGNEMTFSANAIDALMRFEDCRAVVYKDSRGLPTAGCGHLVINGEYKVGQQLSEKEIRDLFISDLAPFNRVVNDLTSKAKNGTTQCEHDAMGTFAFNIGASGFSKSSVLYFHNIGKKDVAAKKFILWNKETINGRKVASKGLTRRRGLESEIYEHCKY
Other Proteins in cluster: phalp2_22738
Total (incl. this protein): 59 Avg length: 167,2 Avg pI: 9,22
Protein ID Length (AA) pI
7ZWXa 183 9,48912
1IFvY 148 9,03649
1JRkk 151 9,38365
1KGlm 153 9,62102
1KIni 153 9,62102
1KdbO 151 9,43838
1KpvZ 153 9,56203
1LfdG 151 9,31718
1Lhzv 148 9,56725
1MnRR 151 9,42626
1NKJi 153 9,80572
1a2Ig 213 9,29887
1bHiy 215 9,15362
1bTRm 222 9,23112
1emqr 210 9,31731
1hQJg 156 9,75885
1ka1H 205 9,27824
2FlVB 147 4,89841
2UKDl 153 9,80295
2cThV 153 9,85137
2eQbx 153 9,85137
2fyfJ 153 9,85137
38ejx 151 9,47274
3MTIw 153 9,92409
3OdOy 153 9,80295
4OtKW 151 9,34987
4f4dS 153 9,46952
4f4v9 147 9,82713
4fwXf 148 9,40724
4gIqI 149 9,37095
4jK0E 148 4,28983
4pxNH 153 9,37552
53Lb1 152 9,20159
54Pak 152 9,43651
5JbLT 157 9,89153
5x3GL 153 9,37785
6Gzde 151 9,49492
6YaHg 151 9,45527
75jWy 218 9,34439
7E7Wf 151 9,33388
7GdE6 220 8,88808
7Skim 157 9,84982
7vOcF 153 9,66937
7vViH 211 9,23834
830vt 153 6,30398
830yu 211 9,53998
88gj2 152 9,09715
8dUFn 211 9,35399
8elcM 183 9,55720
8jxMO 152 9,18418
8oVJF 148 9,42626
8ootG 151 9,22609
8q0ZU 230 9,48029
8q1lp 222 9,43290
8wc0S 176 7,84582
h8Ri 152 9,25658
qKUK 205 9,69400
A0A977KF95 157 9,49357
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_4451
31DIk
 4919 37,2% 153 9.715E-59
2 phalp2_6830
8n5Jv
 121 38,8% 152 9.715E-59
3 phalp2_34911
4lF8s
 21 30,4% 148 2.325E-54
4 phalp2_28113
7zmZV
 50 35,7% 154 7.436E-53
5 phalp2_2632
6RhYr
 14867 36,4% 148 5.545E-50
6 phalp2_4532
3QBcV
 9 36,6% 153 1.991E-46
7 phalp2_26378
1q5mp
 207 36,4% 151 7.014E-46
8 phalp2_33221
5jbqV
 447 36,0% 150 1.192E-44
9 phalp2_32792
2snIK
 45 34,8% 152 3.063E-44
10 phalp2_126
5jCCA
 637 34,4% 151 7.874E-44

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 7ZWXa (183 AA)
Member sequence: A0AAX4AMV8 (157 AA)
1 183 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Erwinia phage FIfi106
[NCBI] 		3073044 Kolesnikvirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OR284297 [NCBI]
CDS location
range 68617 -> 69090
strand +
CDS
ATGGAAGTTTCTCAAAAAGGTCAGCAAGCCCTTGAAGTAATGGAAGGGTTCAGTGCAAAAGCATATCTGGATGTTGCAGGTGTACCGACTATTGGATTCGGTGATACCAGTGTTCGTGCAAGAAAAGTTAAGATGGGTGATACAACCACTCTCGAAGCTGCTAAAGCCGAACTTGCTCTGGATTTGCATGACTTCAAATCAGGTGTTGAAAAGTATCTGGTCAAGGCCGTTAAAGGTACAACACAGAATCAGTTTGACGCTCTTGTAATCTTCGCGTATAACGTGGGATTGACTAACTTTGCTTCTTCAAGCGTACTGAGAAATCATCTTGCAGGGAACTTTGAAGCCGCTGCTGCATCATTTGCACTGTGGAATAAAATCACTGTCAATGGTAAGAAAGTCGTTAGCAAGGGTCTGGTAAACAGACGTGCAAAAGAAGTTGAAATCTACTTGCACAGCAACTATGGCGTTTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7ZWXa) rather than this protein.
PDB ID
7ZWXa
Method AlphaFoldv2
Resolution 93.35
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50