Protein

Protein accession
A0AAX3ZXQ1 [UniProt]
Representative
2QWcf
Source
UniProt (cluster: phalp2_19433)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MDIEKTKEAIKKEEGFRMETYYCTEGHLTGGYGHKMLEGEVPPKDKAGWDKLFERDFARAVTGADDLLMICPDIDETARNIVVEMVYQMGAYGVSKFKGMLKALQDEDYKQASVEMLDSKWAKQTPNRAKRMAERMANI
Physico‐chemical
properties
protein length:139 AA
molecular weight:15882,1 Da
isoelectric point:5,50
hydropathy:-0,65
Representative Protein Details
Accession
2QWcf
Protein name
2QWcf
Sequence length
272 AA
Molecular weight
29856,34430 Da
Isoelectric point
4,62621
Sequence
MFEEMMAQYERVKADLSGMWAAIDVTMVAAKVSDSLKKSAGTPENANMVDKIEKSRTGGSPVTLQAFTAPVPEEAQSFTPSVQEEEVGVFTDTTADTTVSDLGNEEELMSLLDEEDEFLNNEGYKGDVLDMELFKSQLVEDEGLRNKVYEDTEGNLTVGVGHKILPEDNLKRDSVLDSDAVERIFDKDAISAVKQASTLAVNWESLPAQAKHVLANMTFQLGKAGVSKFKKTLDLINKKDFKGASVEMLDSKWAKQTPNRAKKMSALMASIT
Other Proteins in cluster: phalp2_19433
Total (incl. this protein): 9 Avg length: 170,2 Avg pI: 5,31
Protein ID Length (AA) pI
2QWcf 272 4,62621
7FnOa 224 4,53776
8GHKf 199 4,48166
A0A4Y1NUD1 140 5,56803
A0A4Y1NTQ4 139 5,51517
A0A7S5Y9Z4 140 5,92714
A0A7S5YAU4 140 5,92714
A0A6S4P9P5 139 5,73337
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_23727
MWc8
 2 31,4% 181 5.891E-16
2 phalp2_5188
3L6yL
 4 25,1% 219 1.011E-12
3 phalp2_29233
8AsmO
 14 22,0% 204 1.574E-09

Domains

Domains [InterPro]
Unannotated
Representative sequence (used for alignment): 2QWcf (272 AA)
Member sequence: A0AAX3ZXQ1 (139 AA)
1 272 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated

Taxonomy

  Name Taxonomy ID Lineage
Phage Pelagibacter phage HTVC304P
[NCBI] 		3072839 Autographiviridae > Pelagivirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OR420736 [NCBI]
CDS location
range 39656 -> 40075
strand +
CDS
ATGGATATAGAAAAAACAAAAGAAGCTATTAAGAAAGAAGAAGGCTTTAGAATGGAAACCTATTATTGTACTGAGGGTCATCTTACAGGTGGCTACGGTCACAAGATGCTAGAAGGTGAAGTACCACCTAAAGACAAAGCAGGGTGGGATAAACTGTTTGAAAGAGACTTTGCTAGAGCTGTTACTGGTGCAGATGATTTGTTAATGATATGTCCTGATATTGATGAGACTGCAAGAAACATTGTGGTTGAAATGGTGTACCAAATGGGTGCTTATGGGGTCTCTAAGTTTAAGGGTATGCTCAAAGCTCTACAAGATGAGGACTACAAACAAGCTAGTGTGGAAATGCTAGATAGTAAATGGGCTAAACAAACGCCTAATCGTGCCAAACGAATGGCAGAACGAATGGCAAATATTTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (2QWcf) rather than this protein.
PDB ID
2QWcf
Method AlphaFoldv2
Resolution 69.03
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50