Protein

Protein accession
A0AAX3Y730 [UniProt]
Representative
7owpA
Source
UniProt (cluster: phalp2_11865)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MGTEIIDISKWNAGSINWDVLAPQLGLCICRVQYGSNKIDEWYKNYVENLEARNVPHAAYAYGCFVSIADAKVEAEDFHNRTSKNARFLVLDVEDDTVAAMSAAGNLKDLAAASQAFIDHLKAKGWRVGFYVSHHMYGSYNLQSVKADFYWIPRYSTSAPSYYCDLWQYADGETGGYMNGVGKVDRNRLMNGRTLQWFLGETAPVSEPEGIGVATSIYPDGYGVNLYERPSDPIYAGNITSKIPYKVFAGYWGGGDKDMICLGGEKQWAYNKHFTIDWYKVRSKYPVGWGVNFYDGPSGNFLGNIDGSEVYNAHNRVGGYVDIGGNRWIKEEHVTITAK
Physico‐chemical
properties
protein length:339 AA
molecular weight:37942,0 Da
isoelectric point:5,78
hydropathy:-0,38
Representative Protein Details
Accession
7owpA
Protein name
7owpA
Sequence length
346 AA
Molecular weight
38985,95650 Da
Isoelectric point
4,93729
Sequence
MTAEKYIVDISKFNDEINWDVAAPQLELAICRVQYGSNKVDVLYNEHVVNLEKRGVPHAAYAYGCYVSVNDAIVEAKDFLNRVNKNAKFLVLDVEDDTVASMESKGNLGDLAKASQAFIDTCKAAGWKVGLYVSHHMYNQYNLQNVKADFIWLPRYGTNDGQPHEKPSYSCDIWQYTDNGYIKGIGRVDINLLLGDKTLDWYIGDDVNTIAPSKNVGIGIAVSKYSVGYGINLYDAPDGNFTEERFSDQTPHVILEGVWYGGNENMLCFGPSRWAKQEHFDVQWFRAYSKYPPGYGINTYSAPGAPDGSFKGQVDGTTSYEIYSRENGWIDLGQQTFVKEEHFDIR
Other Proteins in cluster: phalp2_11865
Total (incl. this protein): 74 Avg length: 300,6 Avg pI: 6,06
Protein ID Length (AA) pI
7owpA 346 4,93729
1b0eS 336 6,71146
1b1ES 274 5,96914
1cgnZ 279 5,36233
1mrUM 277 6,01683
2YkuC 294 6,06247
3Lm8M 282 5,28122
3LviH 277 5,63186
3LvnA 333 5,34283
4TGlB 266 6,82701
72cke 342 5,41172
72crh 342 5,39205
72gsI 340 6,30222
72nZb 282 5,22535
72rEG 264 7,63765
73hN1 278 5,07688
73hO7 264 5,42587
73hS7 277 5,24098
73wMt 343 6,11601
74cAD 282 5,23330
76oob 276 5,44952
7BBGT 295 5,42746
7Bdz5 273 6,00091
7bNCj 282 5,23330
7cGuJ 331 6,14477
7caA9 343 6,25549
7caAm 342 5,67380
7cayr 286 5,57570
7e3uJ 343 6,11772
7e3zA 282 5,12286
7e8oI 342 5,71422
7f1Kx 293 5,98363
7h8ZN 265 6,32171
7hs62 287 5,56831
7ltv2 287 5,36113
7m7f4 340 6,04781
7mHiX 281 5,49817
7ovC7 267 5,27360
7ovvm 264 6,89414
7ovx8 279 5,44150
7pFXo 331 7,57501
7paDv 266 6,31205
7rFVR 342 5,51142
7rG8f 345 5,83295
7rGSK 277 5,01743
7rGde 346 5,66050
7rGnj 343 5,20329
7rHdr 345 5,21210
7rHjc 342 5,66420
7rHnU 347 5,27911
7rjD9 266 5,75037
7rm8q 323 6,30404
7rmCu 266 6,09083
7rnZk 264 5,41411
7rnlM 264 5,61157
7rnlY 278 5,75247
7roIB 264 5,94180
7roJI 280 5,68267
7rpNM 255 5,47294
7ru4h 280 6,21486
7td3F 274 8,56896
7uzKa 278 6,07651
7uzMZ 266 6,53833
7xv00 266 6,73431
8K2w2 339 5,92191
8fup9 277 5,34709
aO4q 268 5,73690
A7KV11 368 7,50607
A0A218KCJ1 339 5,92191
A0A5J6T672 320 9,62998
A0A5J6T682 320 9,62998
A0A7T7ZAN0 317 9,63972
A0AAE7WZX3 317 9,60684
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_24235
2VKgf
 225 50,0% 210 5.766E-104
2 phalp2_32227
7cHL2
 31 58,4% 212 1.459E-94
3 phalp2_12693
24JaA
 16 37,9% 216 1.381E-44
4 phalp2_11344
7rGpn
 1 23,1% 345 1.868E-20
5 phalp2_34315
3GJC6
 151 24,6% 276 3.774E-18
6 phalp2_10110
c1k0
 16 26,5% 283 7.310E-16
7 phalp2_9568
1jIzS
 2 25,9% 235 2.342E-15
8 phalp2_379
7h79q
 2 22,5% 270 1.354E-13
9 phalp2_37809
4Ez2v
 8 26,4% 223 7.644E-13
10 phalp2_1137
5J3v
 11 26,4% 238 2.366E-10

Domains

Domains [InterPro]
GH25
Unannotated
Representative sequence (used for alignment): 7owpA (346 AA)
Member sequence: A0AAX3Y730 (339 AA)
1 346 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Bacillus phage vB_BceS-M2
[NCBI] 		3061953 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OR096218 [NCBI]
CDS location
range 26297 -> 27316
strand +
CDS
ATGGGTACAGAAATTATTGATATTTCGAAATGGAATGCAGGTTCTATTAATTGGGACGTATTAGCGCCGCAATTGGGCTTGTGTATTTGTCGTGTACAGTACGGCTCAAACAAAATTGATGAGTGGTACAAAAACTATGTTGAGAACTTAGAAGCACGTAATGTTCCTCATGCGGCTTATGCGTATGGATGTTTCGTTTCTATTGCTGATGCGAAAGTGGAAGCTGAAGATTTTCATAATCGTACAAGCAAAAATGCAAGATTCCTAGTTTTAGATGTGGAAGATGATACAGTGGCGGCTATGTCAGCGGCAGGCAATTTGAAAGACCTTGCGGCGGCTTCTCAAGCGTTTATTGACCATCTGAAGGCAAAAGGTTGGCGAGTAGGTTTCTACGTGTCACACCACATGTACGGCTCTTATAACCTACAATCAGTGAAAGCCGACTTCTATTGGATTCCACGTTATAGCACAAGCGCACCTTCTTACTATTGCGACCTATGGCAATATGCTGACGGTGAAACAGGCGGCTATATGAATGGCGTAGGTAAAGTTGACCGCAACCGTTTAATGAATGGTCGTACGCTTCAATGGTTCTTGGGAGAAACTGCTCCTGTGTCTGAACCTGAAGGAATCGGCGTTGCAACTTCTATTTATCCTGATGGATACGGCGTGAACTTATACGAACGTCCTTCAGACCCAATTTATGCAGGTAATATCACAAGTAAGATTCCTTACAAAGTGTTTGCAGGCTATTGGGGCGGCGGCGACAAAGATATGATTTGTTTAGGTGGCGAGAAACAGTGGGCTTACAATAAACATTTCACAATTGATTGGTACAAGGTTCGCTCTAAATATCCTGTTGGTTGGGGAGTCAACTTCTACGATGGTCCGAGCGGTAACTTCTTAGGAAATATTGATGGTTCTGAAGTCTACAATGCTCACAATCGTGTAGGCGGTTATGTAGATATTGGCGGCAACCGTTGGATTAAAGAAGAACACGTTACAATCACGGCGAAATAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7owpA) rather than this protein.
PDB ID
7owpA
Method AlphaFoldv2
Resolution 91.21
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50