Protein

Protein accession
A0AAX3C4F7 [UniProt]
Representative
4ZKl2
Source
UniProt (cluster: phalp2_5806)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MRLGTKIALGVPAAVLAIGIPFTARWEGTETTPYWDSIGRAWTVCMGETNVPMREYTQAECEAMFEPSWSSYYRGMVACFPRLPEAPATVQAMATDLAYNTGTAAVCNSRTTGGHLRAGRWRDFCNVLPSWAMSNGVRVRGLLNRRMDAREVCLSGITE
Physico‐chemical
properties
protein length:159 AA
molecular weight:17532,9 Da
isoelectric point:8,27
hydropathy:-0,11
Representative Protein Details
Accession
4ZKl2
Protein name
4ZKl2
Sequence length
230 AA
Molecular weight
24941,79200 Da
Isoelectric point
9,57899
Sequence
MNNKIEGVATKAGWGVSAGAMSWPWAMPSAETYAHHVNLIVIPTLGALIAALNVLILLRKWRRERRKSFTCDESGAVGRKTLGVMGAAVLALAVPLGVKWEGLRTSPYRDVVGVWTVCVGETNVAMRSYTQAECLAMHEAHLADYYAALLDCMPKLSMAPASVQAAFTDLAYNVGPQTVCRSKNTGGLLRAGLWRKACDALPSWNRAGGKVWQGLTNRREEARRLCLSGL
Other Proteins in cluster: phalp2_5806
Total (incl. this protein): 35 Avg length: 239,4 Avg pI: 9,19
Protein ID Length (AA) pI
4ZKl2 230 9,57899
3GFrk 242 9,09470
4D1Iq 266 9,20262
4Pw67 242 9,67047
4UYDT 247 8,51081
4W2KB 243 9,99139
5IjPA 242 9,74918
63AM 242 9,40840
6Cqck 243 9,74925
6Xsqt 250 9,52864
78i5K 242 9,09489
7JnOu 234 9,29707
7gAMr 242 9,36521
7hTNZ 241 8,98394
7i7FR 242 9,09438
7ig50 241 9,17051
7kzRE 242 9,09457
7os8N 242 9,11262
7pehr 240 7,55728
7qYTk 242 9,36489
7r2xg 242 9,39190
7r36k 242 9,24736
7r3nT 242 9,24736
7r3qC 242 9,36521
7rafD 242 9,66350
7s7wG 233 8,99896
7w6cw 240 8,80691
7wDl5 242 9,56545
7wi1m 239 9,26180
7x6NS 250 7,57814
7yni9 241 9,26283
bvix 234 9,29707
fo9J 234 9,27902
jsLi 242 9,66479
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_4305
8aoFg
 2477 48,0% 152 2.458E-48
2 phalp2_16574
7xiDE
 15 37,1% 191 4.363E-39
3 phalp2_26525
83EoO
 66 38,1% 152 9.939E-38
4 phalp2_35864
4Lj4w
 95 45,4% 165 3.753E-35
5 phalp2_30973
1fTML
 10 31,9% 172 6.671E-32
6 phalp2_22286
7A6Fj
 714 32,7% 162 1.026E-27
7 phalp2_24123
7oopP
 467 29,0% 210 1.674E-26
8 phalp2_8851
2IyxA
 73 36,9% 149 7.885E-26
9 phalp2_3556
4E0oc
 53 36,2% 160 1.075E-25
10 phalp2_8252
7B99h
 46 29,2% 202 9.390E-25

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 4ZKl2 (230 AA)
Member sequence: A0AAX3C4F7 (159 AA)
1 230 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Rhodobacter phage RcCWillis
[NCBI] 		2970510 Casjensviridae >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OP009268 [NCBI]
CDS location
range 47416 -> 47895
strand +
CDS
ATGCGTCTCGGAACTAAGATCGCCCTCGGCGTCCCGGCAGCCGTTCTCGCTATCGGCATCCCTTTCACGGCTCGCTGGGAAGGCACCGAAACGACTCCCTACTGGGACAGCATCGGACGCGCATGGACGGTCTGCATGGGCGAAACCAACGTGCCCATGCGCGAATACACCCAGGCCGAATGCGAAGCGATGTTCGAGCCGAGTTGGTCCAGCTACTACCGTGGCATGGTGGCCTGCTTCCCGCGTCTGCCGGAAGCACCGGCCACGGTGCAGGCGATGGCGACCGATCTGGCCTACAACACCGGCACCGCTGCTGTCTGCAACTCGCGGACCACGGGCGGGCATCTTCGCGCCGGGCGCTGGCGTGACTTCTGCAACGTCCTGCCCTCGTGGGCGATGTCCAACGGCGTCCGGGTGCGCGGTCTCTTGAACCGGCGCATGGATGCCCGCGAGGTCTGCCTGAGCGGGATCACCGAATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (4ZKl2) rather than this protein.
PDB ID
4ZKl2
Method AlphaFoldv2
Resolution 82.21
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50