Protein

Protein accession
A0AAU8B3D4 [UniProt]
Representative
4ueRy
Source
UniProt (cluster: phalp2_2251)
Protein name
Lysozyme
Lysin probability
82%
PhaLP type
endolysin
Probability: 79% (predicted by ML model)
Protein sequence
MDNFKLTSQIEQIVNQLLIQTNLANIPSNMSNNGTPFLPPPKLGTNSSNANSANNGIMPGTYGVITGQTDVLVYNEANLSSSVKTTLPTGQRFLIGAVTGEFYFLEQPVSGFILINRTWVPPQIFTVSQALVEFCASYQDFQAEPYRNANGDWCVGYGENFGQTKPTSVTQEQALTWLQNQLNTNYAPIVATINTELNLGFTQSQFDAITDFIFSAGQEAWVSSCHNGGLGSGIIMCASPQTIMDQFRSWDTVNNRYCQQTWDRRTQEGMMFLYDQYKNYT
Physico‐chemical
properties
protein length:281 AA
molecular weight:31285,6 Da
isoelectric point:4,49
hydropathy:-0,29
Representative Protein Details
Accession
4ueRy
Protein name
4ueRy
Sequence length
210 AA
Molecular weight
24277,82250 Da
Isoelectric point
9,71456
Sequence
MNTKNFKFTKDLILASISLMVVYLVVLFPSSTISESVDCDVYDQYRAKIDHTPIVIEHAEDTMIVQAAKVIMKHEGFSATPYKCTSGKWTQGYGRRIYTKDKSSITKAKAVTWLYEDLKRITASLDRNFPWWRKLDSVRQQAMINFTYNVGIRGVYKFQKFRAAMRMGDFELAAHELKYTGERKTGYFKAVKTRAVQVANAFKYGTWNLT
Other Proteins in cluster: phalp2_2251
Total (incl. this protein): 4 Avg length: 229,8 Avg pI: 8,30
Protein ID Length (AA) pI
4ueRy 210 9,71456
3eKWc 217 9,44534
4ucMi 211 9,55907
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_17008
8jNgs
 3526 39,2% 130 2.442E-32
2 phalp2_32797
2yPO8
 5731 36,6% 153 5.558E-31
3 phalp2_16834
1uDRT
 24 37,0% 135 3.901E-28
4 phalp2_9780
80F6A
 154 35,5% 135 7.783E-26
5 phalp2_7141
2F1c5
 58 34,8% 132 1.979E-25
6 phalp2_22190
6RxcX
 29 35,2% 142 6.869E-25
7 phalp2_24213
2KXlJ
 83 34,4% 151 1.349E-22
8 phalp2_6928
2KMCh
 358 30,6% 163 3.421E-22
9 phalp2_27968
RI1z
 5083 34,0% 141 4.664E-22
10 phalp2_6283
6Psj3
 6 30,0% 130 6.606E-20

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 4ueRy (210 AA)
Member sequence: A0AAU8B3D4 (281 AA)
1 210 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Dulem virus 30
[NCBI] 		3145748 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
PP511706 [NCBI]
CDS location
range 15300 -> 16145
strand +
CDS
ATGGATAATTTTAAACTTACAAGCCAAATTGAACAAATAGTTAATCAATTGTTAATTCAGACCAACCTTGCGAATATTCCAAGCAACATGTCTAATAATGGTACTCCTTTCCTACCTCCCCCAAAGCTTGGCACTAACAGTTCTAACGCTAATAGTGCTAATAATGGAATTATGCCGGGGACTTATGGAGTAATTACAGGACAAACGGATGTATTAGTTTATAACGAAGCTAATTTATCTAGCAGTGTTAAAACCACTTTACCAACCGGACAACGCTTTCTAATTGGTGCAGTTACAGGAGAATTTTATTTTTTAGAGCAACCGGTATCTGGCTTTATTTTAATTAATAGAACTTGGGTCCCTCCTCAAATTTTCACTGTTTCGCAAGCCTTGGTAGAATTTTGCGCAAGTTATCAAGATTTCCAAGCAGAACCATATCGAAATGCTAACGGAGATTGGTGCGTAGGGTATGGAGAAAACTTTGGGCAAACAAAACCCACGAGTGTTACCCAAGAACAAGCCTTAACTTGGCTACAAAATCAACTAAATACAAACTATGCACCTATAGTTGCAACTATAAATACAGAACTAAATTTAGGATTTACCCAAAGCCAATTCGACGCCATAACCGATTTTATCTTTAGTGCAGGACAAGAAGCATGGGTATCTAGTTGCCACAATGGTGGCTTAGGTTCTGGCATTATTATGTGTGCTTCTCCACAGACTATAATGGACCAATTTAGGTCTTGGGACACAGTAAATAATAGATACTGCCAGCAAACTTGGGATAGAAGAACACAAGAGGGCATGATGTTTCTTTACGACCAATATAAAAATTACACATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (4ueRy) rather than this protein.
PDB ID
4ueRy
Method AlphaFoldv2
Resolution 80.97
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50