Protein

Protein accession
A0AAU8B2Z0 [UniProt]
Representative
zkiN
Source
UniProt (cluster: phalp2_30879)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MSVGSVTAEIARRICDEQNVGYSQPDRRTWYANADAHGRVSSPQNADCSSLAAGAVCYGLHHTYRVPWGHRALPEINDHWTGNLRQGLEARGFVEVPWADSDLEPAGGFQAGDIINSAANEGGVGHVVIYVGGGLVSEAWIAEDGSIDGYLGDSTGQETRTGPYASHPHTRAGRWTSAHRFSEAKFFQQWPEFARGRAAAKPAPKPVKPAASLAPVHAHGIDVSSYQGGLNIGALWADFVIVKATEDDDYVNPYMAAQAAATLGASKRLGVYHFARPGDAAAQARYFVNAARAYVGRATFWLDWEANAVAQGPGWAKTFLDTVASLTGSTPGIYMNGSALRGYDWSAVASRYPLWYAGGPSYSSYGQAYSDPAVPSVPYWGQPLIHQYTEDGRLPGYSGTLDLNRCRDRAALDRMVGGGVATAAPAPQNTSGEPQLVVDGEWGPASVGRLKSVMGAVGYDETFAVANLRRFLNKAVPAASQQTLTGSPRLPEDRGWDANVIKVFQYLVLAWRKPGVPAGWTFADWVDGDFGENTVKALQMALNASKAGSYRLW
Physico‐chemical
properties
protein length:553 AA
molecular weight:59363,3 Da
isoelectric point:6,24
hydropathy:-0,30
Representative Protein Details
Accession
zkiN
Protein name
zkiN
Sequence length
327 AA
Molecular weight
36011,63860 Da
Isoelectric point
5,08086
Sequence
VAALWADFVIVKATEDDDYVNPYMGSQANSTLGASKRLGFYHFARPGDAQEQARYFVDAVRGYVGKATLWLDWEANAVDQGPGWAKTFLDAVKGMTGSTPGIYMNGSALNGYDWSAVAREYPLWYAGGGSYSDYGASYSDPAVPSVSYWGSPLIHQYTEDGRLPGYNGTLDLNRLRDRATWDRMIGGGQVISGAPAPVATSGALEVDGEYGPATVQRLIDVFAPGYNELYAVANLRRYLNKTVPEHSQKMLTGSGKLAEDRGWDSHVVRVFQYWAWCWVKPVAPDMWNRFAAGWSFGDYVDGEPGEATWAALQEALNRSRPGSFRLM
Other Proteins in cluster: phalp2_30879
Total (incl. this protein): 42 Avg length: 355,1 Avg pI: 6,38
Protein ID Length (AA) pI
zkiN 327 5,08086
1aey2 366 9,25104
1bY9R 353 9,41369
1c9b6 359 9,26045
1c9hJ 352 9,26799
1cbv5 281 4,79132
1kli2 350 9,42304
2aKU6 357 6,45358
4nPBn 336 5,96499
5C2w3 362 5,77464
5OewB 256 4,58989
5SvUe 260 4,12989
5Vfwi 313 4,63837
5oIL1 322 10,00222
5oJsd 420 5,21455
5tJ2n 326 9,75988
5tRHo 303 9,79412
6YZpv 257 4,90557
6ZLkW 316 5,26559
6b6zT 357 7,72478
7MUS8 257 4,90557
7MgUO 372 5,82863
7cb76 378 5,13003
7t5Y6 281 4,67435
7t623 269 5,51005
7tCW8 281 4,49894
7tD21 282 4,58920
7tQWv 280 4,56147
7ub86 333 8,38168
7ujnJ 279 10,77855
8K2uR 305 6,45182
NtUE 399 6,01075
rkWK 357 5,26559
zhcH 319 4,73238
zkhS 256 9,90210
A0A8S5PBZ5 556 4,97872
A0A8S5QKJ3 540 4,87709
A0A8S5QUJ2 474 5,10570
A0A8S5SL27 477 5,07938
A0A8S5URN6 530 4,39538
A0AA50QA58 563 5,26149
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_22096
5ZSom
 2292 37,3% 249 1.173E-73
2 phalp2_4274
8cjfF
 9 38,8% 229 2.608E-69
3 phalp2_12276
79roT
 46 39,5% 205 2.074E-67
4 phalp2_27394
4HDMm
 9 38,8% 211 1.159E-62
5 phalp2_24845
7umqo
 6 35,5% 214 2.160E-47
6 phalp2_38172
72d4D
 103 30,1% 209 2.945E-47
7 phalp2_39522
5tE9K
 5 28,3% 331 6.984E-42
8 phalp2_37809
4Ez2v
 8 28,1% 252 6.016E-31
9 phalp2_39521
5tDef
 5 26,6% 323 1.632E-27
10 phalp2_13003
3NS3t
 38 28,1% 206 4.559E-26

Domains

Domains [InterPro]
GH25
Unannotated
Representative sequence (used for alignment): zkiN (327 AA)
Member sequence: A0AAU8B2Z0 (553 AA)
1 327 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Dulem virus 38
[NCBI] 		3145756 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
PP511596 [NCBI]
CDS location
range 29407 -> 31068
strand +
CDS
GTGAGCGTTGGATCTGTAACCGCTGAGATTGCCCGTCGGATCTGCGATGAGCAGAACGTCGGCTACAGCCAGCCTGACCGCCGCACGTGGTACGCGAATGCCGACGCGCACGGTCGGGTCAGCAGTCCGCAAAACGCGGACTGCTCCAGCCTCGCAGCTGGGGCGGTCTGCTACGGGCTCCACCACACCTACAGGGTGCCGTGGGGTCACCGAGCGCTGCCCGAGATCAATGACCACTGGACGGGCAACCTGAGGCAGGGGCTCGAGGCCAGGGGCTTCGTCGAGGTCCCCTGGGCTGACTCCGACTTGGAGCCTGCTGGCGGTTTCCAGGCCGGGGACATCATCAACTCCGCCGCGAACGAGGGCGGCGTCGGGCACGTCGTGATCTACGTCGGAGGCGGTCTCGTGTCCGAGGCGTGGATCGCAGAGGACGGGTCGATCGACGGCTACCTGGGCGACTCGACCGGCCAGGAGACCCGCACCGGCCCCTACGCCAGCCACCCGCACACCCGGGCAGGGCGCTGGACGTCGGCCCACCGGTTCAGTGAGGCGAAGTTCTTCCAGCAGTGGCCGGAGTTCGCGCGTGGCCGCGCCGCCGCGAAGCCCGCACCGAAGCCGGTGAAGCCCGCCGCGAGCCTGGCCCCGGTGCACGCACACGGGATCGACGTCTCCTCCTACCAGGGCGGCCTGAACATCGGCGCCCTGTGGGCGGATTTCGTCATCGTCAAGGCGACCGAGGATGACGACTACGTCAACCCGTACATGGCGGCCCAGGCGGCGGCGACTCTGGGCGCGAGCAAGCGCCTCGGGGTCTACCACTTCGCCCGCCCCGGTGACGCCGCAGCCCAGGCCCGCTACTTCGTGAACGCGGCCCGCGCCTACGTCGGCCGGGCGACGTTCTGGCTGGACTGGGAGGCGAACGCCGTCGCCCAGGGGCCTGGCTGGGCGAAGACCTTCCTGGACACGGTCGCATCCCTGACCGGGAGCACGCCGGGCATCTACATGAACGGCTCGGCCCTTCGCGGCTACGACTGGTCCGCCGTCGCCAGCCGCTACCCCCTCTGGTACGCGGGCGGCCCGAGCTATTCGTCCTACGGGCAGGCCTACAGTGACCCCGCCGTCCCGTCCGTCCCCTACTGGGGGCAGCCGCTGATCCACCAGTACACCGAGGACGGACGCCTCCCGGGTTACTCCGGAACGCTGGACCTGAACCGGTGCCGGGACCGCGCCGCCCTGGACCGCATGGTCGGCGGCGGGGTAGCGACGGCTGCGCCCGCCCCACAGAACACGTCCGGTGAGCCGCAGCTCGTGGTCGACGGCGAGTGGGGACCGGCCTCGGTCGGGCGCCTCAAGAGCGTCATGGGTGCGGTCGGATACGACGAGACCTTCGCCGTCGCCAACCTTAGGCGCTTCCTGAACAAGGCCGTCCCGGCGGCCAGTCAGCAGACGCTCACGGGCTCGCCCCGACTGCCCGAGGACCGCGGCTGGGACGCGAACGTTATCAAGGTCTTCCAGTACCTCGTCCTCGCCTGGCGGAAGCCGGGCGTCCCCGCCGGCTGGACCTTCGCGGACTGGGTCGACGGGGACTTCGGTGAGAACACCGTCAAGGCGCTACAGATGGCGCTCAACGCCTCCAAGGCGGGCTCCTACCGGCTCTGGTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (zkiN) rather than this protein.
PDB ID
zkiN
Method AlphaFoldv2
Resolution 88.75
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50