Protein

Protein accession
A0AAF0PIW3 [UniProt]
Representative
3xQtT
Source
UniProt (cluster: phalp2_34303)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKKIADISNLNGNVDVKLLFNLGYIGIIAKASEGGTFVDKYYKQNYTNTKAQGKITGAYHFANFSTIAKAQQEANFFLNCIAGTTPDFVVLDLEQQCTGDITDVCLAFLNIVAKKFKCVVYCNSSFIKEHLNSKICAYPLWIANYGVATPAFTLWTKYAMWQFTEKGQVSGISGYIDFSYITDEFIKYIKGEDEVENLVVYNDGADQRAAEYLADRLACPTINNARKFDYSNVKNVYAVGGNKEQYTSYLTTLIAGSTRYTTMQAVLDYIKNLK
Physico‐chemical
properties
protein length:274 AA
molecular weight:30704,6 Da
isoelectric point:7,47
hydropathy:-0,11
Representative Protein Details
Accession
3xQtT
Protein name
3xQtT
Sequence length
274 AA
Molecular weight
30711,69100 Da
Isoelectric point
8,02014
Sequence
MKKIADISNLNGNVDVKLLFNLGYIGIIAKASEGGTFVDKYYKQNYTNTKAQGKITGAYHFANFTTIAKAQQEANFFLSCIAGTTPDFVVLDLEQPCTGDITEACLAFLNIVAKKFRCVVYCNPSFIKEHLNSKICAYPLWIANYGVATPAFTLWTKYAMWQFTEKGQVSGISGYIDFSYITDEFIKYIKGEDEVENLVVYNDGADQRAAEYLADRLACPTINNARKFDYSNVKNVYAVGGNKEQYTSYLKTLITGSTRYATMQAVLDYIKNLK
Other Proteins in cluster: phalp2_34303
Total (incl. this protein): 28 Avg length: 281,3 Avg pI: 7,55
Protein ID Length (AA) pI
3xQtT 274 8,02014
3wVRd 306 5,39319
3xPJg 306 7,80856
4SvpE 279 8,22960
5HGc1 261 8,82110
5iZVb 276 8,44222
5tD2m 276 5,83472
5tIB0 273 8,56445
7BUDL 274 7,47355
7BdJw 234 9,01025
7BdPF 306 5,76719
7Bkgh 274 9,04790
7BvO8 306 5,58411
7cIYZ 276 8,44924
7cIZh 276 6,22014
7d3P3 313 8,51822
7h4pL 274 9,03249
7kjUF 276 9,00509
7kzGy 306 5,06807
7kzJy 294 5,28639
7kzN4 306 5,16254
7ou3W 277 8,84082
7u29a 274 8,56645
7uZxx 274 8,75141
8Kfkk 272 6,59215
D9ZNF3 274 7,47355
I1TJX3 264 9,07671
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_30706
7cHI2
 66 41,8% 287 3.661E-86
2 phalp2_39458
4VDTp
 155 33,9% 206 7.770E-72
3 phalp2_36157
6TiaL
 25 33,6% 199 6.102E-42
4 phalp2_5615
4g2xP
 40 30,2% 205 7.794E-39
5 phalp2_39912
1jXPT
 300 33,5% 188 2.700E-38
6 phalp2_10644
2AeOK
 60 29,5% 200 5.278E-36
7 phalp2_3425
3TK4D
 923 29,4% 224 1.170E-34
8 phalp2_20360
2RVWF
 69 32,1% 196 3.522E-33
9 phalp2_6199
5X5xO
 102 28,0% 200 6.538E-33
10 phalp2_30061
2NCcc
 23 29,3% 208 6.538E-33

Domains

Domains [InterPro]
GH25
Unannotated
Representative sequence (used for alignment): 3xQtT (274 AA)
Member sequence: A0AAF0PIW3 (274 AA)
1 274 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Clostridium phage vB_CtyS-FA88
[NCBI] 		3065432 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OR113388 [NCBI]
CDS location
range 22747 -> 23571
strand +
CDS
ATGAAGAAAATAGCAGACATAAGTAATTTAAATGGCAATGTAGATGTAAAGCTACTATTTAATTTAGGTTATATAGGCATTATTGCCAAAGCATCAGAGGGCGGCACATTTGTAGATAAGTATTATAAACAAAACTATACAAATACTAAAGCTCAAGGAAAAATAACTGGTGCCTATCATTTTGCAAATTTTTCTACTATAGCAAAAGCTCAGCAAGAAGCAAACTTCTTTTTAAATTGCATAGCAGGTACTACCCCAGATTTTGTTGTATTAGATTTAGAACAGCAATGCACCGGTGATATTACTGATGTATGTTTAGCATTTTTAAATATTGTGGCTAAAAAATTTAAATGTGTTGTATATTGTAACTCAAGTTTTATAAAAGAACATTTAAATTCTAAAATATGTGCTTATCCATTGTGGATTGCTAATTATGGTGTAGCCACACCAGCTTTCACACTTTGGACAAAATATGCAATGTGGCAGTTTACGGAAAAGGGACAAGTTAGTGGCATTAGTGGCTATATTGACTTTAGCTATATAACTGATGAATTTATAAAATATATTAAGGGGGAAGATGAAGTGGAAAATTTAGTAGTTTATAATGATGGTGCAGACCAAAGAGCGGCAGAATATTTAGCAGATAGATTGGCATGTCCAACTATTAACAATGCTAGGAAATTTGATTATAGTAATGTTAAAAATGTATATGCAGTTGGTGGCAATAAAGAACAGTATACTTCATACCTTACAACTTTAATTGCAGGCTCAACAAGGTACACAACTATGCAGGCAGTACTTGATTACATTAAAAATTTAAAATAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (3xQtT) rather than this protein.
PDB ID
3xQtT
Method AlphaFoldv2
Resolution 96.13
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50