Protein

Protein accession
A0AAF0GF80 [UniProt]
Representative
6AkO5
Source
UniProt (cluster: phalp2_8099)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MAKLNKTAIACSLGAIMSAYVALVEPPMPGDMQLSQNGLAELVGLEGCQRGPYKCPAGKWTNGVGHTGPDVTGSTPVIRNAEVAANLRKDIRKFEYCVNRRIGADMTQSQFDSYVLFAFNLGCTEFRNSTLAKLGDAGRHLDSCQQFTKWANMRDPKTKKLLSCKDKKNGCYGLWTRRWRESAICQGKVW
Physico‐chemical
properties
protein length:190 AA
molecular weight:21016,0 Da
isoelectric point:9,36
hydropathy:-0,39
Representative Protein Details
Accession
6AkO5
Protein name
6AkO5
Sequence length
145 AA
Molecular weight
16345,39820 Da
Isoelectric point
5,65692
Sequence
MFINYEQATSLLLADVQEAEQCVRREVKVPLQQSMFDSLVSFVFNLGCGAFRTSTLLARLNEGNYLTAADQFPRWVNAGGRQLPGLVRRRALEQGLFLSGLQLVHNFTLEEQHEKGIESYPDYVYATSMGMRTPSSFIQGYTSIP
Other Proteins in cluster: phalp2_8099
Total (incl. this protein): 4 Avg length: 175,3 Avg pI: 7,66
Protein ID Length (AA) pI
6AkO5 145 5,65692
5nOWV 176 6,20076
A0AA51VJ52 190 9,43142
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_2632
6RhYr
 14867 59,5% 99 1.417E-33
2 phalp2_37101
1bvx6
 877 57,8% 95 5.001E-33
3 phalp2_33221
5jbqV
 447 56,3% 103 1.171E-31
4 phalp2_4451
31DIk
 4919 53,0% 100 6.401E-29
5 phalp2_31105
1YRHZ
 456 51,5% 99 8.973E-26
6 phalp2_9410
8Hj1q
 5109 52,1% 92 1.251E-22
7 phalp2_39267
4724r
 247 48,0% 100 7.460E-21
8 phalp2_23209
7Cg0p
 1 40,2% 97 1.916E-20
9 phalp2_20321
2soYi
 3 43,5% 101 1.138E-18
10 phalp2_19285
8enOZ
 460 43,9% 91 5.469E-18

Domains

Domains [InterPro]
GH24
Disordered region
Representative sequence (used for alignment): 6AkO5 (145 AA)
Member sequence: A0AAF0GF80 (190 AA)
1 145 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Aeromonas phage vB_AsaP_MQM1
[NCBI] 		3038230 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OQ628262 [NCBI]
CDS location
range 51951 -> 52523
strand -
CDS
ATGGCAAAACTAAACAAGACGGCCATCGCATGTAGCCTTGGGGCTATCATGAGTGCCTATGTGGCCCTTGTGGAGCCCCCAATGCCCGGCGACATGCAATTGTCACAGAACGGGTTAGCTGAGCTGGTGGGCCTTGAGGGATGCCAGCGTGGCCCATATAAGTGTCCTGCCGGAAAATGGACGAATGGCGTAGGGCACACTGGCCCGGATGTGACTGGTTCCACTCCGGTCATTAGGAACGCCGAGGTAGCGGCCAATCTCCGCAAGGACATTCGCAAGTTTGAATATTGTGTAAACCGCCGCATTGGTGCTGATATGACTCAATCTCAGTTTGACTCATATGTGCTCTTTGCATTTAATCTGGGATGCACAGAATTCAGAAACTCAACCTTGGCTAAGCTGGGTGATGCCGGAAGGCACCTAGATAGCTGCCAGCAGTTCACCAAATGGGCAAACATGCGTGACCCCAAGACTAAAAAGCTGCTGTCATGTAAGGATAAGAAAAATGGCTGTTATGGCCTCTGGACTCGCCGCTGGCGGGAATCTGCAATCTGTCAAGGAAAAGTGTGGTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (6AkO5) rather than this protein.
PDB ID
6AkO5
Method AlphaFoldv2
Resolution 79.71
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50