Protein

Protein accession
A0AAF0A405 [UniProt]
Representative
1kAuJ
Source
UniProt (cluster: phalp2_29719)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKIDHIPCNRANYYTSGRSLDSIKYIVIHYTANNGDTARGNAKYFARESVGASANYFVDPNEVICSVKDEYAAWHCGGSLESSHHPLRGICTNKNSIGVELCSIIQNGKYEFKPETIKLAAKFVKELMAKYNIDIDHVVRHYDVTGKNCPAPFVYSEEQWKQFKQMLISKEEEETMSYEQWLAYQKRYEQEKANQHVSDYAKSAMEKAVKHGISDGSNPKSHCTREQVVVMLDRAGIL
Physico‐chemical
properties
protein length:238 AA
molecular weight:27118,3 Da
isoelectric point:7,13
hydropathy:-0,60
Representative Protein Details
Accession
1kAuJ
Protein name
1kAuJ
Sequence length
844 AA
Molecular weight
92804,87940 Da
Isoelectric point
7,70813
Sequence
LEDNVNIIKNTNFTAYRNCRERVEKVKYIVIHYTGGEGTAADQVKYFNNGNRSASAHYFVDRSGEIREYCDPKKWYAWHCGGSLESSHHPYYGKCTNSNSIGVEICTHNNGKTWEFTKEAVAAAKELTKYLMKEYDVSADNVIRHYDVTGKSCPRVPGWGAVGGNAEWEKFKKALGAETVDTPATEKKKWYRVRKSWDDAASQIGAYLILDNAIAEANNSGPKYAVYDWTGKEIYRYVEASGTKEKEIRFFYPGYTRTSSPDDRQGAGCVWHDQHKNCFVYDAYQKNTDAGNNLIQYILDNGLRSIDGCGSHAHGDHLGGFFKMLESGKITIENFYCYDPDSLKLAGTGSANARSAKEDKEYLQSLIDKLKARGTKIHFVKTGDTIVCGEMVFEVCRNQPASFGQYDTGKAWGYLNDGSINLYERACHVLLCGDGGGRKAAQYFNGDIDVCESEHHGNGDGSGKVEEVKSRGCGLAIECNNEKNGPGSCGFTQYGARRFKEAGIPVWMLNADINGIAKGGKLTVTQGSGSKTFDVPFGLVFYRVRKSWADAGSQIGAYTILDKAKECADQHPGYIVFDETGKAVYPVEGSGAAPEPAATKPKTEQEIFIETVGTMARDDMAKNGILACITIAQAILESGWGTSELAVNAKNLFGMKKSLSGNTWSGSTWGGKSYSKLTQEVYTSGPAVVRADFRAYESWAESVGDHSAYLAGAKNGSRLRYAGLIGCTDYRKAAQIIKDGDYATAPDYVEKLCKLIEQYNLTEWNSVAAVPAGSGALDEYHTVKWTGMTKRACSGYMYPDARSKVTVEVHQGVKAGVCKGIGKFYLCKVDDTYGYIHKSHITKL
Other Proteins in cluster: phalp2_29719
Total (incl. this protein): 6 Avg length: 530,3 Avg pI: 7,50
Protein ID Length (AA) pI
1kAuJ 844 7,70813
2VjBz 786 9,11140
3iBYE 838 7,06136
A0A2K9V347 238 6,83696
A0AAE9UUR2 238 7,12758
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_28540
41m0Z
 1 34,0% 690 1.044E-101
2 phalp2_15411
21scl
 1 28,1% 750 3.013E-63

Domains

Domains [InterPro]
Unannotated
Unannotated
Unannotated
Unannotated
Unannotated
Disordered region
Representative sequence (used for alignment): 1kAuJ (844 AA)
Member sequence: A0AAF0A405 (238 AA)
1 844 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated

Taxonomy

  Name Taxonomy ID Lineage
Phage Agathobaculum phage AB434P2
[NCBI] 		2968527 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OP172633 [NCBI]
CDS location
range 41240 -> 41956
strand +
CDS
ATGAAGATTGATCATATTCCTTGCAATAGAGCTAATTATTATACCTCTGGAAGAAGTCTGGATTCTATAAAGTATATAGTTATTCATTACACGGCAAATAATGGCGATACAGCACGTGGCAATGCAAAATACTTTGCAAGAGAAAGTGTAGGAGCTTCTGCTAACTACTTTGTTGATCCAAACGAAGTTATTTGTTCTGTAAAGGATGAATATGCAGCATGGCATTGTGGCGGATCTCTTGAGAGTAGCCATCATCCATTAAGAGGAATCTGTACTAATAAGAATTCCATTGGTGTAGAACTTTGCTCTATAATTCAAAATGGTAAATATGAATTTAAGCCAGAAACTATAAAGCTTGCAGCTAAGTTTGTAAAGGAACTAATGGCAAAATATAATATTGATATTGACCACGTAGTTCGGCATTATGATGTAACAGGTAAAAATTGTCCCGCTCCATTTGTTTATAGTGAAGAACAATGGAAACAATTTAAGCAAATGCTTATTAGTAAGGAGGAAGAAGAAACTATGAGTTATGAGCAATGGTTAGCATATCAAAAGAGATATGAGCAAGAAAAGGCAAATCAACATGTTTCTGATTATGCTAAGTCTGCTATGGAAAAGGCAGTAAAACATGGTATTTCTGACGGATCTAATCCTAAGTCCCATTGCACACGAGAACAAGTAGTAGTTATGCTGGATCGTGCAGGAATCCTCTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0009254 peptidoglycan turnover biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0071555 cell wall organization biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.5.1.28 None Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00001561

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (1kAuJ) rather than this protein.
PDB ID
1kAuJ
Method AlphaFoldv2
Resolution 69.43
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50