Protein

Protein accession
A0AAE9YK10 [UniProt]
Representative
7eZhu
Source
UniProt (cluster: phalp2_8197)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MAIAMMAILFGVVSVGKAQAAYSIDKTFAFNANQGSTQRASNMWVILHEAGVVAPGKNVAANMKNNYTPYTAYSTFVVGDGGHVYQVGEPGYVAYAAGNANGYSPVQIELQRTYDKAVFAKNYATYIELARDYANKYGIPLTLDAGGANTSGIKSHLWITQNVWGDHTDPYAYLASMGVSKAKLASDLANGTSSVGGGETTAPTTPTVPNQSNEWAENWHFTNGDQPIQARIGTPSLSAPNAGKLPANTTIYYDRVAIRDGYVWCHWTTDRGDSVWMPVHPVGTANNIWVSFN
Physico‐chemical
properties
protein length:293 AA
molecular weight:31521,8 Da
isoelectric point:6,36
hydropathy:-0,23
Representative Protein Details
Accession
7eZhu
Protein name
7eZhu
Sequence length
321 AA
Molecular weight
34708,76170 Da
Isoelectric point
9,32324
Sequence
LGLPTINKSHTLGPNQGDARQAIKLMVILHESGNQNDVYDPNAILNEVKYMRIHFNDAYATYFVGGGGQIYQIGEPGYVAWAALSANPYAPVQIELARTADRATFLKDYATYIELARKSAKDFGIPLTLDTGGAGTPGIKTHQWVTNNYGGDHVDPYAYFASWGITKARLATDLANGVGTVTPTNPNIVTVKYVSGYGVNALDKYGRQIKGSNLRLKHGTAWKAFGVYILGGVVAYDIGGGWYLPQQYTDQAGIVTVNYAPGYGVLAVDANGKHINGSNVKFKTGTKWKSSAARLIKGKVFYQLSKTEFLEAAYTNGGGYK
Other Proteins in cluster: phalp2_8197
Total (incl. this protein): 48 Avg length: 305,1 Avg pI: 8,36
Protein ID Length (AA) pI
7eZhu 321 9,32324
1Z0pf 248 9,86780
28wUN 329 7,64714
28wdu 329 7,14088
2llvj 274 9,89030
3xFcg 311 7,11388
5HDUG 324 9,16091
5HLST 324 9,18483
5ODFU 321 9,80998
5tIfB 326 6,64802
5tWUd 323 5,65556
5tWv8 321 7,69744
5tXKQ 324 9,87677
5tXdk 323 7,04539
5twys 324 9,87677
6AJQU 324 9,05086
71LZ0 251 9,61361
7226a 328 5,38427
751Kp 329 9,78039
79EVl 251 9,92363
79EVq 253 9,68484
7b7PG 251 9,68394
7cW7n 328 6,31410
7cW7s 328 5,88189
7eEWQ 254 9,68433
7eNQT 330 9,67865
7ebCK 282 9,77059
7fMJl 316 8,25668
7hSJV 326 8,81774
7iNDT 253 9,57828
7iNok 326 6,37054
7lBQi 316 8,55349
7lCqo 332 9,67865
7lFCE 254 9,82229
7o7Pb 328 6,71282
7o7S6 347 7,78812
7qOaV 322 5,81994
7vAWK 308 5,86785
7vFB4 328 5,70211
7vQBQ 253 9,65931
7vQK5 328 5,65653
7vQej 253 9,73751
7wyL5 253 9,54475
8oq1A 356 9,62005
8oqcV 327 9,28978
A0AAF0AFS9 291 8,96054
A0A9Y1HTZ1 302 9,02359
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_32244
7rT4s
 46 38,9% 231 2.628E-55
2 phalp2_38686
KaEr
 718 29,4% 238 2.094E-37
3 phalp2_2718
7jRsp
 11 22,2% 234 4.313E-14
4 phalp2_7313
4e1GY
 5 23,0% 221 1.390E-07

Domains

Domains [InterPro]
Ami2
Unannotated
Representative sequence (used for alignment): 7eZhu (321 AA)
Member sequence: A0AAE9YK10 (293 AA)
1 321 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Latilactobacillus phage TMW 1.2272 P1
[NCBI] 		3027589 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OQ240260 [NCBI]
CDS location
range 38464 -> 39345
strand +
CDS
TTGGCCATCGCGATGATGGCTATTTTATTTGGGGTTGTTTCAGTGGGAAAAGCACAAGCTGCTTATTCTATTGATAAAACATTTGCGTTTAACGCTAACCAAGGAAGCACACAGCGTGCTTCAAACATGTGGGTAATCTTGCATGAAGCCGGTGTTGTAGCGCCTGGCAAAAATGTAGCGGCTAACATGAAGAACAACTACACGCCTTACACCGCATATTCAACGTTTGTTGTTGGCGATGGTGGTCACGTCTATCAAGTTGGCGAGCCCGGTTATGTTGCATACGCGGCTGGTAATGCCAACGGATATAGCCCAGTTCAAATCGAATTGCAACGGACGTACGACAAGGCGGTATTTGCAAAAAACTACGCAACGTACATCGAACTGGCACGAGATTACGCCAACAAGTATGGCATCCCATTGACGCTTGATGCTGGTGGTGCTAACACATCCGGTATCAAATCGCATTTATGGATTACTCAAAACGTGTGGGGTGACCATACAGACCCATACGCCTACTTAGCTTCTATGGGCGTTTCAAAAGCTAAATTAGCTAGTGACTTAGCAAATGGAACTAGTTCAGTTGGTGGCGGGGAAACGACTGCACCAACGACGCCAACAGTACCAAATCAATCAAACGAATGGGCTGAAAATTGGCACTTTACGAATGGTGACCAACCAATTCAAGCACGTATTGGCACGCCATCATTAAGTGCACCAAATGCTGGTAAGTTGCCAGCCAACACAACAATCTACTACGATCGTGTTGCAATCCGCGACGGATATGTTTGGTGTCACTGGACAACAGACAGAGGAGACTCAGTTTGGATGCCCGTTCATCCAGTTGGCACTGCTAACAATATTTGGGTGTCATTTAACTAG

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0006508 proteolysis biological process None (UniProt)
GO:0008233 peptidase activity molecular function None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7eZhu) rather than this protein.
PDB ID
7eZhu
Method AlphaFoldv2
Resolution 94.01
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50