Protein

Protein accession
A0AAE9X4E7 [UniProt]
Representative
7D9tM
Source
UniProt (cluster: phalp2_27442)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKRLVAPIAAMVVVGAAGTGLIKQSEGTRYRSYLDDAGIPTICTGHTGPEVKLGQMKTLEECDTLLKQDLLRHSAAVNRCVNYPLTQYQYDAVVSFTFNVGPTAFCRSTMARKINAGDLQGASAEFPKWNKVRIDGKLVVSRGLSARRDRERALFEGRYPK
Physico‐chemical
properties
protein length:161 AA
molecular weight:17739,3 Da
isoelectric point:9,62
hydropathy:-0,27
Representative Protein Details
Accession
7D9tM
Protein name
7D9tM
Sequence length
401 AA
Molecular weight
44179,20500 Da
Isoelectric point
5,65016
Sequence
MPDIKLKEAAKFYGEEPHQVKAWDWLEGELKPAQLSGFQVRYRNDGAKPEAPSADQPALSNPLQVPYDCQLDNPSGDGWRECFSSSCAMAAMYWGAIKHQDEYHAVRPKYGDSTDPSAQIRTLQSFGLDARFVQVGSIEKLKAQIDRGRPAPVGFLHHGTVKAPSGGGHYILAIGYTDTHLIAHDPYGELDVVNGGYPKTGGTYGKEIQYSWKNWAPRWSVANDHDGWGLDVWKPGAEVPASPKPEAGQEDPGLIPTATGAKGIALIKEFEGCRLETYICPAGVPTCCVGHTGPEVRMGQTYTMSQCEELLRNDLDRFEKAVRDLIDVPIDQCEFDALVSFAFNCGQGALADSTLRRRLNNRESKPKVFAEELPRWTSGGMAGLVRRRDAEVKLANDKVFP
Other Proteins in cluster: phalp2_27442
Total (incl. this protein): 13 Avg length: 257,6 Avg pI: 7,56
Protein ID Length (AA) pI
7D9tM 401 5,65016
4S4Xx 402 5,61509
6BpG9 396 5,69785
6OMFE 392 5,78799
F4YCN5 383 5,94618
H2ELT8 168 8,92857
A0AAE8YJ26 166 8,73052
A0AAE9WWZ9 161 9,56261
A0AAE9X664 161 9,56261
A0AAF0B4Q3 161 9,53689
A0AAX4NC60 166 8,90413
A0AA95FMH6 231 4,69174
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_9409
8H6wD
 41 31,3% 421 2.546E-52
2 phalp2_10421
20UhE
 95 32,8% 314 3.945E-43

Domains

Domains [InterPro]
Unannotated
PET_C39
GH24
Representative sequence (used for alignment): 7D9tM (401 AA)
Member sequence: A0AAE9X4E7 (161 AA)
1 401 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959, PF13529

Taxonomy

  Name Taxonomy ID Lineage
Phage Caulobacter phage ERS
[NCBI] 		3020392 Autographiviridae > Percyvirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OQ137560 [NCBI]
CDS location
range 43446 -> 43931
strand +
CDS
GTGAAACGCCTAGTCGCCCCGATTGCTGCCATGGTGGTAGTCGGGGCCGCTGGCACCGGGCTGATCAAGCAGTCTGAGGGTACCCGCTACCGTTCGTATCTGGACGACGCGGGTATCCCCACTATCTGCACGGGCCATACTGGACCCGAGGTCAAGCTGGGCCAGATGAAAACCCTAGAGGAGTGCGATACTCTCCTCAAACAAGACCTGCTGCGACATAGTGCCGCAGTGAACAGGTGTGTTAACTACCCCTTAACCCAGTACCAGTATGATGCTGTGGTCAGCTTCACCTTCAACGTCGGCCCGACTGCGTTCTGTCGCTCTACCATGGCGCGAAAGATCAACGCGGGTGACCTACAGGGTGCATCTGCCGAGTTCCCGAAGTGGAACAAGGTGCGGATCGACGGCAAGCTGGTGGTTTCCCGTGGGCTCAGCGCCCGCAGGGACCGGGAAAGGGCTCTCTTTGAAGGAAGGTACCCGAAATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016020 membrane cellular component None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0020002 host cell plasma membrane cellular component None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7D9tM) rather than this protein.
PDB ID
7D9tM
Method AlphaFoldv2
Resolution 86.51
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50