Protein

Protein accession
A0AAE8YGU4 [UniProt]
Representative
6S6V5
Source
UniProt (cluster: phalp2_9226)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MSQGEIVSDQAAKLALPIVAEFEGFRPHPYPDPASPLAKATRKEPWGHVPARSILNRLPAATAALSGAPWTIGYGQTGKFITPDTAPWSDAVARANLEEEVQIRVDAVRARAKRDGGTLQDAQVAAMASFLFNVGEGRKASGSDPGKDGLFMLKSGRPSTLWRKAMEGCHTCAADQFPVWNKAGGQVMAGLTRRRAAERSLYLRAG
Physico‐chemical
properties
protein length:206 AA
molecular weight:22068,9 Da
isoelectric point:9,69
hydropathy:-0,34
Representative Protein Details
Accession
6S6V5
Protein name
6S6V5
Sequence length
190 AA
Molecular weight
20506,21960 Da
Isoelectric point
8,50436
Sequence
MNALQLAYDHCAAFEAFRSFPYPDPASPLAEAAPKCRWGLEPATGILADLPLGVRLLSGDPWTIGYGQTGKTIGPNTPPWSQAVGRANLEARLESHIETIDKRAMRQLREGQMAALAGFLDNVGPGAEGRKDGLFVLKSGGPSTLWHCVVEGMDARAANEFLKWARAGGQVLPGLLRRRQAERALYLQAA
Other Proteins in cluster: phalp2_9226
Total (incl. this protein): 37 Avg length: 193,6 Avg pI: 8,81
Protein ID Length (AA) pI
6S6V5 190 8,50436
1gMtJ 184 5,62066
1hT7d 203 9,51065
1pRvJ 201 8,73355
2SLJw 184 5,65169
2TgOb 184 5,77907
2oQbg 192 5,37438
2prC4 192 5,37438
35DWQ 191 10,51507
3NRd4 201 9,51026
4Vpkw 200 9,37662
4XUTg 193 9,89965
4uhCX 153 9,20262
4zZ1z 188 9,78587
6FmnC 192 6,29125
6Uihv 183 6,58402
7jToN 204 9,50266
7jTp1 207 8,65851
7lKeH 204 9,35012
7lKgo 202 9,11939
7wHCO 201 9,09438
7yXtq 201 9,03758
7z4Rb 202 9,76466
7z4Tc 202 9,73874
8HipS 200 9,72888
8eGlb 176 9,93911
8nEoF 188 9,40080
OVJe 180 9,05815
gQ6d 191 10,25345
K7ZLE2 200 9,72888
A0A679K1K2 200 9,94929
A0A679KAT8 200 9,84118
A0A679KCU0 200 9,88779
A0A679KL84 200 9,94929
A0A9N6WST6 169 8,77294
A0AAE9C6X3 200 9,90165
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_37804
4EicH
 34 40,2% 184 3.461E-55
2 phalp2_30561
5EHHM
 5 32,0% 178 4.120E-41
3 phalp2_29165
7sDhB
 3 30,8% 185 5.092E-40
4 phalp2_2176
3Yhf4
 930 33,3% 192 1.307E-39
5 phalp2_33221
5jbqV
 447 32,9% 188 1.790E-39
6 phalp2_2498
5GMvl
 297 32,0% 187 2.726E-37
7 phalp2_8252
7B99h
 46 28,3% 180 3.361E-36
8 phalp2_2632
6RhYr
 14867 32,4% 188 5.095E-34
9 phalp2_28113
7zmZV
 50 30,3% 191 3.346E-33
10 phalp2_9410
8Hj1q
 5109 37,3% 126 6.904E-31

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 6S6V5 (190 AA)
Member sequence: A0AAE8YGU4 (206 AA)
1 190 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Xanthomonas phage MET23-P3
[NCBI] 		2894301 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OK913680 [NCBI]
CDS location
range 36735 -> 37355
strand +
CDS
GTGTCCCAGGGGGAAATTGTGTCCGACCAAGCCGCGAAGCTCGCGCTGCCCATCGTTGCCGAGTTCGAAGGGTTCCGCCCGCACCCGTATCCCGATCCCGCCAGCCCGCTGGCCAAGGCGACGCGGAAGGAACCGTGGGGCCACGTCCCCGCCCGCTCCATCTTGAACCGTCTGCCGGCCGCCACCGCGGCGCTGTCCGGCGCGCCCTGGACCATCGGTTACGGGCAAACGGGCAAGTTCATCACCCCCGACACCGCCCCCTGGTCCGACGCTGTGGCCCGCGCGAACCTGGAAGAGGAAGTGCAGATCCGCGTCGATGCGGTGCGCGCCCGCGCCAAGCGCGACGGCGGCACGCTGCAGGACGCCCAGGTGGCGGCCATGGCCAGCTTCCTGTTCAACGTCGGCGAAGGCCGCAAGGCATCGGGCAGCGATCCGGGCAAGGACGGGCTGTTCATGCTGAAATCCGGCCGGCCCTCGACCCTGTGGCGCAAGGCCATGGAAGGGTGCCACACCTGCGCAGCGGACCAGTTCCCGGTCTGGAACAAGGCCGGCGGGCAGGTAATGGCGGGCCTCACGCGCCGTCGCGCCGCGGAGCGTAGCCTGTACCTTCGGGCGGGCTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (6S6V5) rather than this protein.
PDB ID
6S6V5
Method AlphaFoldv2
Resolution 96.33
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50