Protein

Protein accession
A0AAE8BDK8 [UniProt]
Representative
1q5mp
Source
UniProt (cluster: phalp2_26378)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MFQISQRGINDIKLSEGFRSKAYLDSAGIPTIGYGTIRINDVPVKMGMVCTVEEAERYLRQDLKVFEMEVNKAIAGVPTTQNEYDALVNICYNIGVSNFRSSTFLKRHKAGNKIGCAKAFEMWCKVTVNGRKVTNQGLLNRRIREADMYLRGIYQSK
Physico‐chemical
properties
protein length:157 AA
molecular weight:17783,4 Da
isoelectric point:9,54
hydropathy:-0,31
Representative Protein Details
Accession
1q5mp
Protein name
1q5mp
Sequence length
234 AA
Molecular weight
25602,00450 Da
Isoelectric point
8,63710
Sequence
MRTSQRGIDIIKRSEGVKLVAYFCPANVPTIGVGHTRTVTRADVHAQRRITVEEAERLLSEDLASFERGVLRLCTLPPNQNQFDAFVSLAFNIGLGAFERSTALRRHNEGDFDAAAGAIEMWNKATVNGKRVVLRGLVARRADEKALYLTPVEPELMTQAVEDEPTLASSRTIQGGAVAGGATVAAVIADTTEQVRLLTFLPPDTLQYLLAGLALMGIGAVLYARWDDWRKGRR
Other Proteins in cluster: phalp2_26378
Total (incl. this protein): 207 Avg length: 249,8 Avg pI: 8,09
Protein ID Length (AA) pI
1q5mp 234 8,63710
10Fa0 260 9,17716
10Ky8 249 8,88253
10UBA 230 8,82799
10rhm 248 9,31963
11nWF 260 9,01257
14GG7 256 8,56380
14LP8 255 7,05147
14MEj 254 7,66078
15ASj 237 6,32109
15BB0 188 5,47657
15C3x 265 6,97849
15w2o 236 6,62296
15zOT 238 8,79002
1GAuy 271 9,40151
1IG2L 236 8,53370
1J3OW 259 6,16455
1KMct 223 9,71682
1M9cI 253 8,60139
1Mfgy 266 9,25929
1NUtd 253 9,54276
1OyBa 242 9,60884
1XKXl 243 6,75238
1XLfA 212 7,66573
1XMtf 256 5,31941
1Xfmn 204 9,29558
1XoT4 195 6,29960
1XyN5 253 8,20710
1XzWQ 252 7,61446
1d8VA 296 6,98764
1d9cw 291 9,48905
1dW3W 266 9,12294
1gyhz 265 7,77639
1pzZM 244 9,42381
1rH92 253 8,88286
1y8Nc 242 9,57467
2Hhj3 252 6,19900
2QiEc 241 8,47838
2nNNK 231 9,60303
2qTV 254 8,43538
2tZbE 223 9,33755
34wwq 254 7,73820
36IKl 244 9,02643
3I9Q 280 9,09373
3Igf8 237 6,75062
3MT9e 278 9,36270
3PtN 300 9,37449
3c0Hg 264 8,76095
3dCvv 275 9,15227
3iNAT 300 10,09705
44QjG 270 7,79276
455Bu 270 7,09012
4C6jG 299 10,02762
4DpQc 265 6,59653
4FOcZ 254 7,77677
4JmKo 242 9,07497
4Ksli 258 6,12135
4KtlP 247 9,68768
4LLOe 264 6,13210
4MW8n 236 9,59639
4SRJH 260 7,61309
4Vefh 146 4,99702
4W0eU 247 5,34448
4Yv7H 263 9,23124
4cpsH 253 5,79032
4dYWD 297 9,48938
4eGMU 266 8,98710
4eJAH 254 6,42095
4eJYC 212 8,64323
4eT2m 238 8,84559
4eVK7 252 6,89306
4eXH9 252 6,61540
4enFB 256 8,97324
4eqvU 252 6,30114
4ey7V 238 8,84559
4f8Yx 239 5,65340
4fW4L 237 9,02617
4fWf8 242 9,36753
4fnZ0 253 6,43039
4fpMp 252 5,49772
4fq8K 238 9,07310
4fw2I 237 9,25690
4g0gz 255 9,07001
4g3jZ 259 5,97136
4g4uJ 237 9,29275
4n4rw 236 8,67836
4v83c 216 9,02643
4v8a5 226 6,43153
4v8fU 271 6,23361
4vg8V 271 6,53537
4vgdt 216 9,29333
4yXkd 270 8,86448
52Vfr 270 5,06813
53FJP 250 10,06205
5Do5T 237 5,58741
5EkF5 193 9,63804
5ErvU 245 8,77764
5IMvM 245 8,40901
5IeyU 263 8,61145
5b4gF 250 10,10492
5dnZk 233 9,70799
5ffT9 259 5,61731
5kJVf 258 7,77645
5kb3J 249 7,02276
5kf08 258 9,35051
5rCuv 227 10,10421
5xZ06 251 9,13809
5yXav 198 5,15975
60Kb 254 6,65996
60Ke 254 8,00525
6BLry 249 7,69318
6Ldq0 263 9,49679
6MzpV 251 6,82963
6Nb6u 284 6,95422
6NtQz 250 10,43048
6PPzh 240 7,67908
6Q07N 257 7,17720
6R6XF 257 7,12382
6RdFf 236 7,68522
6Rft6 247 8,78706
6RoEI 252 6,21974
6RxOK 218 7,88598
6U8xe 278 8,97163
6U8zf 255 6,11004
6VBcQ 258 6,90329
6wX3T 212 9,87386
73fGY 257 6,43783
7E7Ty 277 8,70750
7KHX9 252 8,54717
7RqQv 254 6,43783
7UTtE 256 8,95700
7UtWn 257 8,75405
7VxM9 244 9,05525
7XpCw 266 7,68136
7YQ8j 270 8,64284
7YVdF 252 8,67817
7YhYI 237 6,90437
7apr2 282 9,00818
7owGE 238 6,21429
7qreA 283 8,94333
7rfF6 243 9,66196
7sevx 244 9,50743
7sv5v 257 9,35090
7vDTY 223 9,38223
7vGM0 263 5,77100
7vVhH 261 8,76971
7vVjX 243 8,46188
7waiB 279 9,53940
7whqt 269 9,25619
7yfje 254 9,38629
81jH7 232 9,79992
81lxq 240 8,86545
82GNH 234 8,77210
83L18 254 8,50617
83WTM 224 8,80549
83zMK 287 9,82480
8Hj3m 257 6,49121
8aK9T 255 7,62998
8aPGA 254 8,34300
8anQO 214 8,58231
8b4UK 252 5,99290
8dH4D 251 7,65010
8dHTR 258 8,50346
8e2bG 266 6,61932
8eGqI 254 5,80738
8eHrh 257 7,79044
8eImI 268 8,88150
8hBnX 266 6,74840
8iRmH 259 5,93515
8isRA 255 7,71546
8isZQ 237 9,25690
8j420 238 8,96776
8j9a2 252 5,98784
8jajE 251 8,45885
8jlwG 256 7,70296
8kzhh 256 8,75869
8mDfY 263 9,17587
8oJhg 271 8,23321
8qGUg 268 8,36505
8reUe 258 6,83963
8sYWC 256 8,51784
8t8lV 259 6,75522
8thZo 274 8,71672
9WoS 265 6,59556
C8Gt 242 9,39067
SpEy 239 8,71698
W5Z4 306 7,71137
XFPB 237 6,43994
bU6M 209 9,24801
bfSh 242 9,63082
bi6G 262 8,36273
csS7 278 9,24607
f7Ky 256 8,19956
f7q1 253 8,70312
iJ5q 254 8,68017
iO4A 244 9,22138
jmpN 243 8,48779
jnuE 241 8,48779
l469 264 8,75244
lIJt 255 5,97363
lyoV 238 8,92573
pIKB 237 6,75062
sLt5 217 5,21989
tCBN 259 6,33371
zd4I 250 7,76144
A0AAE7W9H8 157 9,53657
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_2498
5GMvl
 297 51,0% 239 1.438E-78
2 phalp2_18211
4LtVv
 4 41,6% 204 5.348E-66
3 phalp2_29738
1pBjt
 830 49,7% 199 1.241E-64
4 phalp2_6732
24SaC
 23 40,6% 241 2.877E-63
5 phalp2_30676
6Q25R
 25 42,5% 216 4.869E-62
6 phalp2_10966
4MkR6
 70 39,0% 243 2.344E-61
7 phalp2_33221
5jbqV
 447 56,4% 154 6.016E-61
8 phalp2_28113
7zmZV
 50 53,0% 149 1.544E-60
9 phalp2_6830
8n5Jv
 121 56,4% 147 1.544E-60
10 phalp2_40579
4SZ2W
 11 42,8% 210 1.017E-59

Domains

Domains [InterPro]
GH24
Disordered region
Representative sequence (used for alignment): 1q5mp (234 AA)
Member sequence: A0AAE8BDK8 (157 AA)
1 234 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Hafnia phage vB_HpaM_SarahDanielle
[NCBI] 		2836113 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MW749010 [NCBI]
CDS location
range 53577 -> 54050
strand -
CDS
ATGTTCCAAATCTCTCAACGTGGTATCAATGACATTAAATTGTCAGAAGGTTTCCGCAGTAAAGCTTATTTAGACTCTGCTGGTATTCCTACCATCGGGTATGGTACAATTAGAATCAACGACGTTCCTGTCAAGATGGGTATGGTGTGTACTGTTGAAGAAGCTGAACGTTATCTTCGTCAAGACTTAAAAGTCTTTGAAATGGAAGTTAACAAAGCTATTGCAGGTGTACCAACCACACAGAACGAATATGATGCTCTAGTAAACATCTGCTACAACATTGGTGTTTCAAACTTTAGAAGTTCAACCTTCCTGAAACGTCATAAAGCTGGTAATAAGATTGGATGTGCAAAAGCTTTTGAAATGTGGTGTAAGGTTACTGTCAACGGACGTAAAGTAACTAATCAAGGTTTACTCAATAGACGTATTCGTGAAGCAGATATGTACCTACGTGGTATCTACCAGTCTAAATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (1q5mp) rather than this protein.
PDB ID
1q5mp
Method AlphaFoldv2
Resolution 83.83
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50