Protein

Protein accession
A0AAE7WB68 [UniProt]
Representative
8Mwp5
Source
UniProt (cluster: phalp2_29261)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 61% (predicted by ML model)
Protein sequence
MIRWEITPDNTTLLTEIKEFEGTKEYQAAWKQKSFRNGRFWVYKDHLGYDTIGYGHLVKKGEDFSKGLTEAEAERLLATDLKTSVEAAFDIATKKNISDQFIIQLTLVEMVFQLGKEGVLGFSNTLSKMASKDYKGAADGMLNSKWARQTPERVSKMAERVRALA
Physico‐chemical
properties
protein length:165 AA
molecular weight:18736,2 Da
isoelectric point:8,69
hydropathy:-0,46
Representative Protein Details
Accession
8Mwp5
Protein name
8Mwp5
Sequence length
893 AA
Molecular weight
96227,73990 Da
Isoelectric point
5,65920
Sequence
MGDNSTSKSMEFSKNQNARFNPQFVQLATVMDNRDPTKTGKLKVWVQNSQSDKDSKGSWLTASYLSPFAGRTPGTPGAESYQQFPKGYGFWAVPPDVGVTVAIFFANGNIHECWWFACGYDDRMNTMVPGAASQNMPNSGYDMPVPITDYDRNTIQTQLDQKYVNVPLVEGLKKQNLLYDAQKGVPNRSSTRQTISTTYGMASPRGNTFVMDDGYTDAELTAPNWDDDQDSYQNTQFNNPVNDTAVGTRKNEGIILRTRSGAQFLLSESDGNVFLINRDGTARFEMTVDGQILVHATKSITFRTEEDFNFTASRDINFEAGRNLNMSIQGDTKLNLVGKLDAIVNGQVVINAGADLRLVAGASIRVQSGSSTNITSGSNTAITASSTVDIKGSAVNIGGGGNNLTIKGDSTASTAPMGAPDFKTPSVGLSDHIHLHQSFVDASNHSDQMAPPVQGGGNSSADAPATAEPANDVAPEAPQQQAQETVQHVNSTSEVGQVLSQDLVVSDGGEDNTTVSYTTTYEGLQMFMPCTGTIREFGYWGKGVPTQSGSTTNRNGWIIQAKGDVVAPDGGLVTKISTGGLIITHPTGYKSVFYDINITVNNKDTVTKGQKIGTANGVFDFEIRLQSANIYGFSGTVDPGLFYSTVTGKGASAANKSLIAGKPSNLNPAPVTGYSENSSELVVITTVNSIGSVYSQRGSRHVPRRTSTTKRNTNSTARAPAEDLSSLDKTSIDWKVTASDGKLIEEVKEFEGTIQYQTAIGYFRGGRFWIYKDSLGYPTIGYGHLITANDNFPGGIDEPTADALLQKDLVRTVRDAQSIYAQYNMKTPYIVQIVLTEMVFQMGKGKVLKFKNTLAALASGDYKGAAAGIRNSAWYSQTPRRAEVMARRVEACE
Other Proteins in cluster: phalp2_29261
Total (incl. this protein): 67 Avg length: 616,4 Avg pI: 7,09
Protein ID Length (AA) pI
8Mwp5 893 5,65920
1dbUN 899 5,52943
1gMqY 897 5,55979
37Uyb 874 5,18749
3OAo6 676 5,45128
3OBjV 880 5,75537
3OpFL 891 5,96908
4Z5pf 899 5,46799
5hYUZ 891 5,92014
5ipz4 892 5,96908
71eSH 889 5,81016
7PFZq 887 6,04133
7PdEw 886 5,48555
885Om 887 6,31734
8J37d 894 5,58866
8J37f 887 6,04133
8J37j 894 6,02820
8LjeG 893 5,97954
CpyP 895 5,49363
A0A482GBA5 887 6,04133
A0A097EYH3 162 9,30081
H6X3N5 886 5,48555
K4F6U4 162 9,12758
K4FB41 894 5,58866
A0A097EYI1 887 6,04133
A0A1L2CUV5 894 6,02820
A0A1S6UAK3 162 9,12758
A0A1S6UAR4 893 5,97954
A0A1L2CUW3 162 9,23150
A0A2C9CYE4 162 9,12777
A0A0A8J8N9 886 5,48555
A0A1C3S7H9 162 9,30081
A0A2C9CZ39 893 5,74303
A0A2I7SAT8 883 4,87556
A0A2Z5HIT2 258 9,71308
A0A3Q9R6C9 162 9,32156
A0A3Q9R6F3 889 5,93464
A0A411BFN1 887 6,17763
A0A411BFN9 162 9,20397
A0A482G9W7 162 9,30081
A0A4Y5NWJ6 889 5,93634
A0A4Y5NWK4 162 9,32156
A0A4Y5P1M6 165 8,70770
A0A5A4U6Z0 162 9,30081
A0A6G6XV99 889 5,93634
A0A6G6XVD5 162 9,32156
A0A7L8G5M2 162 9,35560
A0A7L8ZL82 162 9,12758
H6X3N0 162 9,35560
A0A9E7MGR6 162 9,27843
A0A9E7SFB1 887 6,04883
A0A9E7T0L6 162 9,18721
A0A9E7T2Q0 887 6,55390
A0A9E8VNS1 162 8,88872
A0A9E8VP44 887 6,55941
A0A9X9JXJ8 162 9,25948
A0A9X9JZU2 899 5,47674
A0AA96PSQ9 889 5,93293
A0AAF0CYC6 162 9,09696
A0AAF0CYQ0 897 5,67449
A0AAF0K5Y3 887 6,17763
A0AAU7PGY1 887 6,17763
A0AAX4ATV7 162 9,38307
A0AAX4F900 162 9,22144
A0AAX4F9I2 887 6,04377
A0AAX4ATT3 880 5,45577
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_9037
5ghTb
 15 24,8% 701 2.253E-43
2 phalp2_22943
3cStN
 49 22,5% 757 1.623E-21

Domains

Domains [InterPro]

No domain annotations available.

Taxonomy

  Name Taxonomy ID Lineage
Phage Erwinia phage KEY
[NCBI] 		2821255 Demerecviridae >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MZ616364 [NCBI]
CDS location
range 85678 -> 86175
strand +
CDS
ATGATACGTTGGGAAATAACACCTGATAATACAACGCTATTAACAGAAATTAAGGAGTTCGAGGGGACTAAAGAGTATCAAGCAGCTTGGAAACAAAAATCATTCCGTAATGGAAGGTTTTGGGTTTATAAAGACCATCTAGGGTATGATACTATTGGTTACGGACACCTTGTCAAGAAAGGAGAGGATTTCTCTAAAGGACTAACTGAAGCAGAAGCAGAACGTTTGCTGGCTACTGATCTAAAAACTTCTGTAGAAGCAGCATTTGACATTGCTACTAAGAAGAATATTAGTGATCAGTTCATCATTCAGTTAACTCTAGTAGAGATGGTATTCCAGTTAGGGAAAGAAGGAGTACTAGGATTTAGCAATACGTTAAGTAAAATGGCTAGTAAAGACTACAAGGGTGCAGCAGATGGGATGCTAAACTCTAAATGGGCCAGACAAACTCCGGAACGCGTCAGTAAAATGGCAGAAAGAGTAAGAGCATTGGCTTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (8Mwp5) rather than this protein.
PDB ID
8Mwp5
Method AlphaFoldv2
Resolution 75.15
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50