Protein

Protein accession
A0AAE7SA10 [UniProt]
Representative
7cHL2
Source
UniProt (cluster: phalp2_32227)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MAKELILDVSHHQDPNNFNWAKLKDEIDLILIRVQYGSNTIDRQYKKFVELAEKHKIPFGHYAYGVFVSSKDAVVEANNFLKRGDSEATVWILDVESDTIESCKNSPLGEASQAFIDTLSKAGKKTGFYYEHLILENMV
Physico‐chemical
properties
protein length:139 AA
molecular weight:15840,7 Da
isoelectric point:5,50
hydropathy:-0,34
Representative Protein Details
Accession
7cHL2
Protein name
7cHL2
Sequence length
283 AA
Molecular weight
32005,64930 Da
Isoelectric point
9,63714
Sequence
MNKLIVDISHWQPTNKINWARAALEVALFIIRVQYGSLKHDREYKNHVANAKKHGIPFGHYAYALFRDVEDAKREARDFLARADKDAKFLVVDVEEQTCKNPKDIVPATQAFIDVCKAAGWKVGLYTGHHFYKPHRMDLVKADFVWIPRYGTNSGKPETKPAYPCDLWQYTDKGRVSWYNGSLDLNLLAGSKTLEWFIGAQKPVAPKPPSKPIEAAKPGEKYPGHLIKKGNKGTLVKKVQIKVGAKPDGIFGPETEAKVKAWQKAKKIKVDGIVGPQTWREMF
Other Proteins in cluster: phalp2_32227
Total (incl. this protein): 31 Avg length: 314,9 Avg pI: 8,83
Protein ID Length (AA) pI
7cHL2 283 9,63714
1Gy0n 397 9,65628
25etF 328 9,38042
2G2f7 319 9,62824
2G4kH 283 6,99923
2G5BB 286 8,67823
2G6C4 282 8,30948
2ZNfG 364 9,14228
39zxN 271 5,76952
4C5yl 286 8,65548
4MPuU 329 9,52909
4STyf 331 9,39841
4SU2T 326 9,53605
5u1Eh 281 8,29671
5u1L5 284 9,13938
5u28P 287 8,92367
746UQ 272 5,16942
7805O 339 9,87142
7806n 246 9,63411
7l5UF 370 9,79573
7luoY 339 9,50498
7ovbE 277 9,30035
81f1h 286 8,87751
8KPkc 390 9,55803
HONY 330 9,17135
bM7h 286 8,65071
A0A223LD43 390 9,55803
A0A172JIA8 390 9,52696
A0AAE7SFE5 390 9,46920
A0AAE9YH55 382 9,52696
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_354
72wcG
 31 49,3% 245 3.185E-81
2 phalp2_32637
21xEV
 86 53,8% 206 1.244E-78
3 phalp2_24235
2VKgf
 225 50,4% 212 5.952E-72
4 phalp2_12693
24JaA
 16 39,7% 289 3.224E-55
5 phalp2_2120
3gPQA
 3 35,2% 204 4.109E-39
6 phalp2_29740
1rkWk
 100 30,9% 297 1.042E-38
7 phalp2_29128
7804q
 3 38,0% 231 1.421E-38
8 phalp2_19565
3TIJJ
 398 31,2% 224 2.935E-32
9 phalp2_3439
3WDPn
 5 29,3% 293 5.439E-32
10 phalp2_23950
235xP
 13 32,6% 199 1.021E-29

Domains

Domains [InterPro]
GH25
PG_1
Representative sequence (used for alignment): 7cHL2 (283 AA)
Member sequence: A0AAE7SA10 (139 AA)
1 283 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF01471

Taxonomy

  Name Taxonomy ID Lineage
Phage Listeria phage LPJP1
[NCBI] 		2852115 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MZ422438 [NCBI]
CDS location
range 173144 -> 173563
strand +
CDS
ATGGCAAAAGAACTTATTTTAGATGTTTCTCATCATCAAGATCCCAATAACTTTAACTGGGCTAAACTTAAAGATGAAATCGATCTAATACTAATTCGTGTACAATATGGATCAAATACTATTGACCGTCAATACAAGAAATTTGTTGAGCTTGCTGAAAAACATAAAATTCCTTTTGGTCACTATGCTTATGGTGTATTTGTTAGTTCTAAAGATGCAGTAGTTGAAGCTAATAACTTTTTAAAACGTGGTGATAGTGAAGCTACTGTATGGATTTTAGATGTAGAATCCGACACTATTGAGTCATGTAAAAATTCTCCTCTAGGTGAAGCTTCTCAAGCATTTATCGATACTCTTAGCAAAGCCGGAAAGAAAACTGGTTTTTACTATGAACATCTTATATTGGAAAATATGGTTTAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7cHL2) rather than this protein.
PDB ID
7cHL2
Method AlphaFoldv2
Resolution 92.15
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50