Protein

Protein accession
A0AAE7S5I0 [UniProt]
Representative
5IWY5
Source
UniProt (cluster: phalp2_24666)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKTSEKGIETLELEEGNVLRAYRCPAGKWTIGMGLTAASGVVNPKAGMVITAQQSRDLTKKALAAKYEPRVALVMTGARQHEFDAGVLFDWNTGAIQKASWVPLWARKAGKSAIAEKFKLWNKGGGNVLPGLVARRERELRILFEGMYPVLGEPSRPSVSVARWVLQLDFAEKIAAMTAFNKLGYPVGLDSAAIPAAEIRRFQRDHSLTADGKIGRATLSTLQRRIDAAEKAKPVALASVSTTATGISATAPTGTSDITDWIAAQPWAIGAAAGAVGLWGLWLAWAYRDVIAAKIQGRAPRLAATLRSI
Physico‐chemical
properties
protein length:309 AA
molecular weight:33146,0 Da
isoelectric point:10,06
hydropathy:-0,02
Representative Protein Details
Accession
5IWY5
Protein name
5IWY5
Sequence length
240 AA
Molecular weight
25134,18910 Da
Isoelectric point
10,94333
Sequence
MRTSARGIAQLEADEGVVLRAYRCPAGVWTIGAGLTAASGVVRPEAGMTITREEASRLLSLALERNYEPAVRAAMPGAARHEFDAGVSFHFNTGAIARASWVSAWRRGDWPAVERGILAWNRGGGRVLPGLVARRRREFALLRHGTYHVADPDALRPASLDESAAAGGAAARLALPLRASDAPRVAAALQRLGYGPATHPGGVSAAALRAFQRDHDLTVDGIAGRATAAALERALAGAPN
Other Proteins in cluster: phalp2_24666
Total (incl. this protein): 127 Avg length: 308,6 Avg pI: 9,92
Protein ID Length (AA) pI
5IWY5 240 10,94333
11KfS 318 9,85407
13gFQ 309 9,95845
13h8X 229 9,45147
16QyL 307 9,68839
16kAa 346 6,79171
179ZO 326 10,01589
1ZulJ 303 9,49511
1cI99 322 9,43928
1d389 300 9,59736
1fPhe 315 9,90720
1nxqs 332 9,82584
1qZOX 299 10,34893
1r3jD 312 9,85568
1rFQj 308 10,15392
1rGSN 334 9,64790
1rupB 295 10,32714
1rvkU 304 10,03549
2An3k 329 9,78599
2CiPU 301 10,42604
2FR6 301 10,15991
2G2KI 307 9,85014
2G3Rg 305 10,10879
2OxJj 302 10,17783
2P6fu 301 10,02640
2UcI9 304 10,34681
2cNv8 320 9,62366
2ct9y 307 10,37021
2tRws 305 9,17948
37bZT 316 10,09164
3OIKh 293 7,15207
3TaoP 347 7,96753
3tLwp 306 9,80134
3yRCI 302 9,82970
3yRdN 301 10,43081
4DrGD 301 10,20601
4KurW 304 10,18731
4Kv7A 335 10,06572
4Mtea 307 9,81636
4Mtu8 313 10,23682
4QCHF 316 10,12645
4Qsuh 305 9,68239
4Ry47 250 10,07636
4SKgI 319 9,72230
4YJHx 314 9,95903
4YKcp 315 9,81423
4ZFQ1 317 9,66537
4ZLEu 306 10,03097
4ZMFV 306 9,96896
4a6k6 311 10,39799
4f47J 314 9,95026
4gGyP 294 9,76910
4gHeU 316 9,87032
4jqh7 302 10,02292
4l5qQ 316 9,72146
4nPRU 306 8,86145
53Ffg 304 10,69152
5BTDK 304 10,18570
5CTvB 311 9,72965
5CabX 304 10,47664
5Duiu 295 10,09454
5EHno 302 9,98939
5b3cb 304 10,79937
5buEr 304 10,24984
5fW2t 304 10,68488
5ge8s 302 10,51661
5kbt0 335 10,21220
5lYdS 304 10,14173
5la5p 316 9,90591
5liiq 305 10,24914
5sJfZ 313 9,86465
5uCUO 304 10,75063
5vjzc 304 10,41366
5yPBU 304 10,47664
5z0O9 339 9,53553
64KA 287 9,14988
64Tr 302 9,78896
6A9Rf 309 9,81326
6BMsA 305 10,19247
6EAEp 340 9,36037
6EKM7 340 9,44367
6PP93 313 10,91986
6xTzw 308 10,19795
71Z3K 317 9,29603
72ApB 306 11,08561
72b8p 317 9,77581
72qjD 286 10,62015
7GROf 308 9,92886
7HGEc 305 10,66592
7HJgx 321 9,85066
7HNiC 311 9,88012
7VsXe 303 9,95310
7csJx 278 10,22580
7dwVJ 326 9,57551
7ePkv 309 10,02369
7h9pq 309 10,39483
7m9Ey 309 10,03297
7m9Lu 310 9,92841
7peiI 307 9,79741
7phhv 309 10,09428
7phif 310 10,19930
7rNwO 320 10,04638
7rODQ 304 9,51233
7rQaS 299 9,59826
7rUc9 298 9,96206
7rVOI 303 9,70476
7rWFG 296 9,56816
7vNcT 306 9,70425
7vXqp 311 10,14392
7vzz5 299 9,99745
7wC6m 305 10,75257
7wc5n 303 9,64017
7z5bD 306 10,43622
7zHMB 295 10,65374
7zh4X 326 9,43548
7zm4u 326 9,38210
7zwB2 318 9,70431
8Hj30 301 10,21452
8Hj31 310 10,23959
8paTN 355 7,21380
J1iK 304 10,81162
htKS 355 8,71937
uMBA 330 10,01557
wudP 289 9,57434
G8GWD3 309 10,02369
M4STA9 301 10,21452
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_38866
1Mo76
 29 33,4% 245 1.752E-50
2 phalp2_1642
8qFOb
 229 36,3% 253 2.638E-48
3 phalp2_34307
3A2Hz
 178 30,9% 239 1.107E-43
4 phalp2_28113
7zmZV
 50 38,2% 175 7.871E-41
5 phalp2_10966
4MkR6
 70 31,8% 207 1.593E-38
6 phalp2_2498
5GMvl
 297 37,8% 148 9.202E-37
7 phalp2_18895
1XjBO
 673 35,2% 176 2.345E-36
8 phalp2_34878
4dXDH
 390 39,8% 148 2.345E-36
9 phalp2_11510
IqVv
 15 35,4% 161 3.203E-36
10 phalp2_33221
5jbqV
 447 41,2% 148 4.376E-36

Domains

Domains [InterPro]
GH24
PG_1
Representative sequence (used for alignment): 5IWY5 (240 AA)
Member sequence: A0AAE7S5I0 (309 AA)
1 240 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959, PF01471

Taxonomy

  Name Taxonomy ID Lineage
Phage Rhodobacter phage RcWaterboi
[NCBI] 		2835983 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MW677528 [NCBI]
CDS location
range 13349 -> 14278
strand +
CDS
ATGAAAACCAGCGAAAAAGGCATCGAGACGCTTGAGCTCGAAGAAGGCAACGTCCTGCGGGCCTATCGGTGCCCCGCGGGGAAATGGACCATCGGCATGGGTCTGACCGCAGCTTCGGGCGTCGTCAATCCGAAAGCTGGCATGGTGATCACCGCGCAGCAATCGCGCGACCTGACCAAGAAGGCGCTCGCTGCCAAGTATGAGCCCCGTGTCGCCCTGGTGATGACCGGTGCCCGGCAGCACGAATTCGACGCTGGCGTGCTTTTCGACTGGAACACCGGCGCGATCCAGAAGGCCTCTTGGGTGCCGCTCTGGGCGCGCAAGGCGGGCAAATCGGCGATCGCCGAGAAATTTAAGCTTTGGAACAAGGGCGGCGGCAATGTCTTGCCGGGCCTTGTTGCGCGGCGCGAGCGCGAATTGCGCATCCTGTTCGAGGGCATGTACCCGGTGCTGGGCGAGCCCTCGCGGCCCTCGGTCAGTGTCGCGCGCTGGGTGCTGCAGCTGGATTTCGCCGAGAAGATCGCGGCGATGACGGCCTTCAACAAGCTCGGCTATCCGGTCGGCCTCGATTCCGCGGCCATCCCCGCGGCCGAGATCCGCCGCTTCCAGCGCGACCACAGCTTGACCGCGGACGGCAAGATCGGCCGCGCCACCCTGTCCACGCTGCAGCGGCGCATCGATGCCGCCGAGAAGGCCAAGCCGGTCGCCCTGGCGAGCGTCAGCACCACGGCAACCGGCATCAGCGCCACGGCCCCGACCGGCACCTCGGACATCACCGACTGGATCGCGGCGCAGCCGTGGGCGATTGGTGCCGCAGCCGGGGCTGTCGGCCTCTGGGGTCTGTGGCTCGCGTGGGCCTACCGCGACGTGATCGCCGCGAAAATCCAAGGCCGCGCGCCGCGCCTGGCCGCGACCCTGAGGAGCATCTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016020 membrane cellular component None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (5IWY5) rather than this protein.
PDB ID
5IWY5
Method AlphaFoldv2
Resolution 84.92
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50