Protein

Protein accession
A0AAD2GRE8 [UniProt]
Representative
41rlL
Source
UniProt (cluster: phalp2_21403)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MGIKTRVGYCSVAVVLALVSTNHKDEIRTSPAGLELLAGYEDCRTQAYLDIVGVPTCGIGSTSGVRMGTTWTEEQVAAAFVKDVQAAEKCVLVYFNGYAMPQPVFDSVTSLVFNTGCWGARWNSKLNRPTGIAQYAKSEDWQNVCYRLGDFIYAGGKVSNGLKNRRAKEQAHCVKWQVPQQYEGSRWTPNPH
Physico‐chemical
properties
protein length:192 AA
molecular weight:21176,8 Da
isoelectric point:8,66
hydropathy:-0,26
Representative Protein Details
Accession
41rlL
Protein name
41rlL
Sequence length
243 AA
Molecular weight
27327,94670 Da
Isoelectric point
9,34825
Sequence
MFTSNAGRNLIKQYEGCKLKAYKCPSGVYTIGYGHTKGVKADMRITKAQAEDLLTQDLATVESAVNIYVNRYKLNQNEYDSLVSFTFNCGAGNLNKLCNKGLRKKSAIADKMLAYNKGNGKVLAGLTARRLAERKLFLTPVSTVAMGIDYSHVFDANYYANRYSDLKKAFGTDAKALFEHFLVYGMREHRQAIATFNVDKYISYSSNADVVNACTNPKTKELDIVKVYKHYCEFGYKENREAV
Other Proteins in cluster: phalp2_21403
Total (incl. this protein): 6 Avg length: 198,0 Avg pI: 8,94
Protein ID Length (AA) pI
41rlL 243 9,34825
A0A9E7M7I9 192 8,97047
A0A9E8G8Z5 192 8,97047
A0A866D1Q0 177 8,69403
A0AB39CC00 192 8,97047
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_34008
81fvs
 10 42,5% 162 1.770E-38
2 phalp2_16385
5LDDR
 25 50,0% 186 4.005E-37
3 phalp2_26378
1q5mp
 207 46,2% 158 1.374E-24
4 phalp2_28322
16R6i
 5 36,8% 187 1.188E-19
5 phalp2_23227
7HiLX
 27 39,6% 179 2.972E-19

Domains

Domains [InterPro]
GH24
Unannotated
Representative sequence (used for alignment): 41rlL (243 AA)
Member sequence: A0AAD2GRE8 (192 AA)
1 243 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Klebsiella phage vB_Kpl_K59PH2
[NCBI] 		3071671 Autographiviridae >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OY757063 [NCBI]
CDS location
range 2952 -> 3530
strand +
CDS
ATGGGTATCAAAACTCGCGTAGGCTACTGCTCGGTGGCCGTAGTCCTGGCCCTGGTCAGTACCAACCACAAGGATGAGATTAGAACCTCTCCCGCCGGGCTGGAGCTTCTGGCTGGATATGAGGACTGTCGCACCCAAGCCTACCTGGACATCGTAGGAGTCCCTACGTGCGGCATTGGCAGCACCTCTGGGGTTCGTATGGGCACTACCTGGACAGAGGAACAGGTGGCCGCTGCGTTCGTTAAGGACGTACAGGCGGCTGAGAAGTGTGTCCTGGTGTACTTCAATGGGTACGCTATGCCACAGCCCGTGTTCGACTCTGTGACGTCCCTGGTGTTCAATACCGGGTGCTGGGGTGCCCGCTGGAACAGCAAGCTGAACCGCCCTACAGGCATAGCTCAGTACGCTAAGTCTGAGGACTGGCAGAATGTGTGTTACAGATTGGGTGACTTCATCTATGCTGGCGGTAAGGTCTCTAATGGCCTCAAGAACCGTCGGGCGAAGGAGCAAGCTCACTGTGTCAAATGGCAAGTACCGCAACAGTATGAGGGTTCCCGATGGACTCCAAATCCCCACTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (41rlL) rather than this protein.
PDB ID
41rlL
Method AlphaFoldv2
Resolution 97.40
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50