Protein

Protein accession
A0AAC8REK6 [UniProt]
Representative
7sDhB
Source
UniProt (cluster: phalp2_29165)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MQVTPTGRKLLIEREGRRNHAYPDPASPMALKARSRHWGLRPAADILKDFPPEVAKLSGAPWTCGIGITGVDIDADTHWDDRTVDRKFKEHLFDFSADVASLLETDTAPHEFDALVSLAFNIGTPRFRTSTVLRCHNAGDRAGAARAFHLWNKAQGSVNQGLVNRRAKEATQYLNGYSTANADLPPTPDTERSMAKSEINIASGAAAVTAGATAVSSVFDA
Physico‐chemical
properties
protein length:221 AA
molecular weight:23910,5 Da
isoelectric point:7,06
hydropathy:-0,39
Representative Protein Details
Accession
7sDhB
Protein name
7sDhB
Sequence length
253 AA
Molecular weight
26959,78260 Da
Isoelectric point
6,51076
Sequence
MLSDLFAAILALFRRAPAPAPVIRDNKIIGPVSGGIQFGKSPTLPGSTPVVAPLVPVPVTAPAPGAKPEVAAPHGPTWIDLCRPMTEHFERCVLIAYPDPASELGVAIQARGQWEHVLNGMAIPQDLLHLDGAPWTCGYGCTGADIVYGTVWTPAHADSQLTIRLNQAADAVDRRVKVEITPAQKGALADFVFNEGEENFATSMLLRLLNASDFVGAAAQFARWDLAKGKVMPGLVTRRAANKQLFTTGAWQP
Other Proteins in cluster: phalp2_29165
Total (incl. this protein): 3 Avg length: 242,3 Avg pI: 6,37
Protein ID Length (AA) pI
7sDhB 253 6,51076
7nWM1 253 5,52216
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_37804
4EicH
 34 54,4% 193 3.687E-67
2 phalp2_3516
4qTfc
 7 43,8% 162 5.264E-39
3 phalp2_9226
6S6V5
 37 41,4% 181 1.522E-34
4 phalp2_2176
3Yhf4
 930 38,7% 204 6.636E-31
5 phalp2_33221
5jbqV
 447 41,2% 165 9.399E-29
6 phalp2_4532
3QBcV
 9 33,8% 213 9.667E-27
7 phalp2_15055
7rwX8
 6 32,5% 206 3.904E-25
8 phalp2_26875
4eHC1
 6 33,1% 187 7.253E-23
9 phalp2_8851
2IyxA
 73 34,2% 190 2.432E-20
10 phalp2_29484
1KOZ4
 4 31,3% 153 3.301E-20

Domains

Domains [InterPro]
Disordered region
GH24
Representative sequence (used for alignment): 7sDhB (253 AA)
Member sequence: A0AAC8REK6 (221 AA)
1 253 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage EBPR siphovirus 1
[NCBI] 		1048520 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
JF412302 [NCBI]
CDS location
range 53805 -> >54466
strand +
CDS
ATGCAAGTAACCCCGACTGGCCGCAAGCTTCTCATTGAGCGAGAGGGCCGCCGCAATCATGCTTACCCTGACCCTGCCAGCCCAATGGCCCTGAAAGCGCGAAGCAGACACTGGGGCCTTCGCCCTGCTGCTGACATTTTGAAAGACTTCCCGCCTGAAGTCGCCAAACTATCTGGCGCACCGTGGACCTGCGGGATTGGCATAACTGGCGTGGACATTGACGCAGACACGCATTGGGACGATCGGACAGTAGACCGCAAGTTCAAAGAGCACCTCTTTGACTTCTCTGCTGACGTAGCTTCACTACTGGAAACGGACACTGCACCTCATGAATTCGACGCCCTGGTCTCTCTGGCTTTCAATATCGGCACGCCACGCTTTCGCACTTCTACTGTTCTGCGATGTCATAACGCGGGTGATCGCGCAGGCGCAGCCCGTGCTTTTCATCTCTGGAACAAAGCCCAAGGTTCCGTGAATCAAGGTCTCGTCAATCGCCGTGCGAAGGAAGCTACTCAATACCTGAATGGCTACAGCACAGCGAATGCAGATCTGCCTCCCACACCTGACACAGAGCGCTCTATGGCCAAGAGCGAAATCAATATCGCATCTGGGGCTGCCGCTGTGACAGCAGGTGCCACTGCAGTATCCTCTGTATTTGACGC

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
upi0002147e9c_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (7sDhB) rather than this protein.
PDB ID
7sDhB
Method AlphaFoldv2
Resolution 79.85
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50