Protein

Protein accession
A0AA96A6R0 [UniProt]
Representative
7zmZV
Source
UniProt (cluster: phalp2_28113)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MSAAELFSQLRQMSGGKLTQEQVDAGDKIIKVLGDDVFAKLIGLKVKSGNMDISEAGYKLIKDFEGFSATSYKDTGGVWTIGYGTIKYPSGNAVKAGEKCTKEQADMWLKNDCKWVDACLDSSVKVPLKQNQFDALASFIYNIGENGFKKSTMLAKLNAGDYIGAAGQFDRWVYDNGKFIQGLANRREKEKALFLS
Physico‐chemical
properties
protein length:196 AA
molecular weight:21541,4 Da
isoelectric point:8,61
hydropathy:-0,33
Representative Protein Details
Accession
7zmZV
Protein name
7zmZV
Sequence length
225 AA
Molecular weight
24737,53110 Da
Isoelectric point
9,77620
Sequence
MKISQTGINLIKQFEGCYLTAYKCPAGVWTIGYGTTGKVDGKQICSGMKINKQKAEQLLKKDLEQFEKAVSAIVKVPINQNQFDALVSFSYNCGSSALRKSTLLRKLNQKDYKGAAEEFLKWNKAGGKVLAGLARRREAERKLFLASSGAKEPSKTHKTTYLTVTANSGLLCRKTASINGQVLGTFTKGTKVELLDGNKEIWYKVKGKCVAGKVIVGYCSSRYLE
Other Proteins in cluster: phalp2_28113
Total (incl. this protein): 50 Avg length: 189,8 Avg pI: 8,75
Protein ID Length (AA) pI
7zmZV 225 9,77620
1Xp50 165 9,89707
1daa8 251 9,26825
1uijz 162 6,92193
1z2D6 162 5,30617
21CWq 227 9,75653
24n4b 227 9,93408
25CM6 165 10,23083
4HUcu 212 5,08649
4MnAK 203 10,41353
67zC7 205 9,69677
6H5rO 218 5,00549
6x5rw 222 8,94359
7Vu2f 209 9,21816
7sBg8 254 9,51175
7vMog 254 9,68523
A0A0M4S5S1 146 7,69557
A0A1B1P9G1 149 9,70986
A0A0M4R365 149 9,01289
A0A7D2HHD8 146 9,21107
A0A3G3BZ23 146 8,71730
A0A068CDE9 184 9,25458
A0A4D6CHH5 137 9,46017
A0A075DXC6 206 8,71524
A0A077KCE6 146 9,50968
A0A0B5KND4 146 9,51871
A0A0B5KZG2 146 9,81513
A0A2S1GLD1 181 8,12742
A0A6G5XWZ3 201 9,62843
A0A6J5KQ60 243 8,37446
A0A6J5L4S9 252 6,12556
A0A6J5PVI7 243 9,20365
A0A6J5SJV4 243 8,76997
A0A6J5TAI0 241 5,96505
A0A6J7W8E8 243 6,70952
A0A6J7WT77 241 6,83599
A0A2Z4GYY9 149 9,20191
A0A6G5Y3M8 221 9,38603
A0A6G5YJX0 146 9,30016
A0A6G5YLE0 146 9,45482
A0A6J5LIA3 143 9,35283
A0A6J5PQB6 148 6,26322
A0A6J7WLV7 143 9,36598
A0A6J7X3M7 171 10,14605
A0A8S5VE33 149 9,23711
A0A9X9P5E3 184 9,09696
A0AAD1QLM1 184 9,54250
A0AAX6NL32 177 9,74712
D6QWN8 181 9,58775
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_2632
6RhYr
 14867 61,6% 146 7.498E-70
2 phalp2_33221
5jbqV
 447 63,5% 148 1.407E-69
3 phalp2_6830
8n5Jv
 121 59,0% 149 3.616E-69
4 phalp2_2498
5GMvl
 297 61,6% 159 2.389E-68
5 phalp2_10966
4MkR6
 70 52,2% 155 2.679E-66
6 phalp2_29738
1pBjt
 830 55,4% 166 1.291E-65
7 phalp2_4451
31DIk
 4919 61,4% 148 2.423E-65
8 phalp2_2176
3Yhf4
 930 57,5% 158 3.033E-61
9 phalp2_126
5jCCA
 637 55,1% 147 1.320E-59
10 phalp2_4532
3QBcV
 9 61,5% 143 4.640E-59

Domains

Domains [InterPro]
GH24
SH3_3
Representative sequence (used for alignment): 7zmZV (225 AA)
Member sequence: A0AA96A6R0 (196 AA)
1 225 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959, PF08239

Taxonomy

  Name Taxonomy ID Lineage
Phage Acinetobacter phage HFM1
[NCBI] 		3073040 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OR246918 [NCBI]
CDS location
range 23073 -> 23663
strand +
CDS
ATGAGTGCAGCAGAATTGTTTTCACAGTTAAGGCAAATGTCAGGCGGAAAACTTACACAAGAACAGGTGGACGCTGGCGACAAAATTATTAAGGTTTTGGGTGATGATGTTTTTGCCAAACTAATTGGATTAAAGGTTAAATCTGGCAATATGGATATTTCGGAAGCGGGATACAAACTCATTAAAGATTTTGAGGGCTTTTCGGCAACATCATACAAGGATACTGGTGGTGTTTGGACCATTGGATACGGAACAATTAAATATCCAAGTGGCAACGCCGTTAAAGCTGGCGAGAAATGCACCAAAGAGCAAGCTGATATGTGGCTCAAGAATGACTGCAAATGGGTTGACGCTTGTCTTGATTCATCTGTTAAGGTTCCATTAAAACAAAATCAGTTTGATGCATTAGCTAGTTTTATTTATAACATCGGTGAGAATGGTTTCAAGAAAAGCACCATGCTGGCAAAGCTGAATGCTGGCGACTATATCGGCGCTGCTGGTCAGTTTGACAGATGGGTTTATGATAATGGTAAATTCATTCAAGGATTGGCTAACCGACGAGAGAAAGAAAAGGCGTTATTTTTAAGCTAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7zmZV) rather than this protein.
PDB ID
7zmZV
Method AlphaFoldv2
Resolution 92.54
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50