Protein

Protein accession
A0AA50AF54 [UniProt]
Representative
7ui6P
Source
UniProt (cluster: phalp2_27792)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MDWLNVEPDKYNLLRRHYTPGRGGANIEFVTLHHMAMIGDVDDCVRVWQDRPASAHYAISPTGMIGQAVNDVDTAWSNANLWSNQRSISIEHSNSAGPDQDWPISEATREAGAHLVAALCRYYKLGRPVSGKNVRFHSIESGGATSCPYHLRPGHKYHDQYIRRAQYWYDQMTSGKPSTAKPVKKESKGITMNAVDQVNAHTRAFITGYLSPQIDALQEVWTQLRGPGGKGWKQLGQDSQGRNLTPVDALAAIRCELAQIQADVNELKRRKK
Physico‐chemical
properties
protein length:272 AA
molecular weight:30433,9 Da
isoelectric point:9,10
hydropathy:-0,65
Representative Protein Details
Accession
7ui6P
Protein name
7ui6P
Sequence length
247 AA
Molecular weight
27554,48170 Da
Isoelectric point
5,30645
Sequence
MAMVGGTDECYNVWLSRPASGHYAIDPSGEVGQLVWDRDTAWGNANLVSNQESLIIEHSNEAGAAADWPIGKTTLETGARLVAALCRFYGLGRPVSGANVRFHSIESGGRTACPYHLRPGHKYHDHYIERAQCWYDEMTKPAVQAPKKEEDFLMSLSAEEQKELLVKTRAIHNVLFAPEPSRVTGSKFKAPLTEFIMQTDRKVEELHVEYRGKASQTQEALDELAEAVESHDESHEVCKMPGEDNEK
Other Proteins in cluster: phalp2_27792
Total (incl. this protein): 19 Avg length: 256,2 Avg pI: 6,96
Protein ID Length (AA) pI
7ui6P 247 5,30645
6Z1hB 259 8,36898
7C2Mi 275 6,15216
7NMoO 261 8,65038
7otAm 282 6,25373
7uuJz 273 6,15313
7w0TU 275 6,07100
wu8D 265 8,87764
A0A1U9WQY2 245 6,75244
A0A1W6JQT7 245 6,75244
A0A1W6JQV6 245 6,75244
A0A1W6JR07 245 6,75244
A0A1W6JR65 245 6,75244
A0A1W6JRA8 245 6,75244
A0A1W6JRK9 245 6,75244
A0A1W6JRP6 245 6,75244
A0A1W6JRQ3 245 6,75244
A0A894JYY3 254 6,45506
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_2841
8IAfz
 3 29,4% 275 6.842E-28
2 phalp2_22065
5F1i1
 7 29,8% 181 1.340E-14

Domains

Domains [InterPro]
Ami2
Unannotated
Representative sequence (used for alignment): 7ui6P (247 AA)
Member sequence: A0AA50AF54 (272 AA)
1 247 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Corynebacterium phage HS01
[NCBI] 		3056389 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OQ890311 [NCBI]
CDS location
range 20215 -> 21033
strand +
CDS
ATGGATTGGTTAAACGTCGAGCCCGATAAATACAACCTGCTGAGAAGGCACTACACACCAGGCAGGGGCGGTGCAAACATTGAGTTCGTCACCCTGCACCACATGGCCATGATTGGTGACGTAGACGACTGCGTGCGTGTGTGGCAAGACCGGCCCGCCAGCGCCCACTACGCCATCTCCCCGACCGGAATGATAGGCCAAGCCGTGAACGACGTGGATACCGCTTGGTCCAACGCGAACCTGTGGTCTAATCAGCGCTCCATCAGTATCGAGCACTCCAACAGCGCAGGCCCCGACCAGGACTGGCCCATCAGCGAAGCCACCCGTGAAGCTGGTGCGCACCTCGTAGCCGCCCTGTGCCGCTACTACAAACTAGGCAGGCCCGTATCTGGCAAGAATGTCCGGTTCCACAGTATTGAGTCCGGTGGGGCTACGTCCTGCCCGTACCACCTGCGGCCCGGACACAAGTACCACGACCAATACATTCGCCGCGCCCAGTACTGGTACGACCAGATGACTAGCGGCAAACCCTCCACGGCTAAGCCAGTGAAGAAAGAGAGCAAGGGGATAACTATGAATGCGGTTGACCAGGTTAACGCCCACACCAGGGCTTTTATCACGGGGTATCTTTCCCCGCAGATTGATGCTTTGCAGGAAGTATGGACGCAATTGAGAGGCCCAGGGGGTAAGGGCTGGAAGCAGTTGGGGCAGGATAGCCAAGGTCGCAACCTAACTCCGGTTGATGCACTTGCGGCGATTCGCTGCGAGCTTGCGCAGATTCAGGCAGATGTCAATGAGTTGAAGCGGAGGAAGAAGTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0009254 peptidoglycan turnover biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0071555 cell wall organization biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.5.1.28 None Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00001561

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7ui6P) rather than this protein.
PDB ID
7ui6P
Method AlphaFoldv2
Resolution 88.48
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50