Protein

Protein accession
A0AA49X436 [UniProt]
Representative
7hFHn
Source
UniProt (cluster: phalp2_15044)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MAKTFKIVDVSSHNGNLYWQKLKADGVDGLIIRAGYGWYNEDPTFIKNVNEAALHGMDYGLYFYTYATEMSEAKQEIEGFLQAIKGLKPTLPVVIDTEDADKWRTRHGNPSWRMLADMLYMQLEKIEKAGYYAMYYASRYWVDNLLAKRPDLKRFDLWLAHWDIAAPSMPCGVWQYTSGGPKYGDGIDRSDLNVGYVDYPALIKKAGLNGWPKAERPVIAADDTKPVTKPTPKNNTIAGAVFDKYENATFIFGAATHVRTLPTTDSQIVATYDIGESVKYDQVYIGNGYVWISYIGQSGNRRFCACRTYRNGKRGEAWGTFK
Physico‐chemical
properties
protein length:322 AA
molecular weight:36488,0 Da
isoelectric point:8,47
hydropathy:-0,44
Representative Protein Details
Accession
7hFHn
Protein name
7hFHn
Sequence length
312 AA
Molecular weight
35770,70180 Da
Isoelectric point
8,97028
Sequence
MAKKVIDISKHNGKIDFSQVRKAVDFIFIRAGFGWSFHLDPRLDEYIRGCREYKIPFGLYCYSYATGLSQAKVEVQGFLQKIQGLHPELPVVIDTEDADGWRRKNGNPSWGEKASMLLYQLREIERAGYYAMYYCSTSWYDQMVRREPELKKYDLWLAHWGIKEPSRPCGVWQYTSDGSVPGIRGRVDMNYAYRDYPTIIREKGLNGFKKPIQTPKLDKKEEDKAKTAPQPRAYLICYEGDGDKPAVDILAQALGTCAMVKKGAPPEEMMDSNIIQVGGEKKTWADIVLSGADRFKTRDKVMDFIKKMEGGR
Other Proteins in cluster: phalp2_15044
Total (incl. this protein): 33 Avg length: 311,8 Avg pI: 4,93
Protein ID Length (AA) pI
7hFHn 312 8,97028
1kmVu 316 4,43494
1knIt 315 4,40556
1kpCZ 316 4,43091
1oqpk 245 4,60131
5QvWh 316 4,39544
6ZLBV 289 4,38197
6ZqEg 316 4,29392
6d9nW 316 4,44779
6eOm8 316 4,43199
6lt7p 316 4,44779
6vB4S 316 4,33877
73o7Y 316 4,43238
73o9o 316 4,39544
746uE 316 4,37896
75rHx 315 4,54083
76ktY 315 4,40453
7Me8a 315 4,34946
7h7fX 316 8,44950
7rCAE 315 4,36844
7vu3o 315 4,35963
8sCHa 285 8,91387
A2sL 316 4,39413
ClVM 315 4,45916
EE65 312 4,40198
KMql 316 4,34394
MYg6 316 4,29392
wAnw 316 4,48684
wMPS 316 4,39544
wUBm 316 4,34394
ydb9 316 4,34394
yqZ4 316 4,54083
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_3425
3TK4D
 923 42,7% 215 3.304E-65
2 phalp2_6199
5X5xO
 102 43,0% 223 2.157E-64
3 phalp2_26548
858CP
 728 30,4% 322 3.595E-63
4 phalp2_36883
7sfSC
 39 41,3% 220 2.344E-62
5 phalp2_10747
3nEcV
 19 35,5% 236 7.538E-56
6 phalp2_10110
c1k0
 16 35,5% 214 9.128E-55
7 phalp2_23789
19iit
 3 34,5% 220 1.042E-50
8 phalp2_529
o3Q8
 73 35,8% 226 1.255E-49
9 phalp2_15589
2brBA
 13 33,2% 268 3.835E-48
10 phalp2_29740
1rkWk
 100 36,6% 199 3.374E-47

Domains

Domains [InterPro]
GH25
Unannotated
Representative sequence (used for alignment): 7hFHn (312 AA)
Member sequence: A0AA49X436 (322 AA)
1 312 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Firmicutes phage HS10
[NCBI] 		3056392 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OQ890317 [NCBI]
CDS location
range 2788 -> 3756
strand -
CDS
ATGGCGAAAACTTTCAAAATTGTTGATGTTTCCAGTCATAACGGCAATCTTTACTGGCAGAAATTAAAAGCCGATGGCGTCGATGGGCTGATAATTCGAGCTGGATATGGGTGGTACAACGAGGACCCGACTTTTATTAAAAATGTCAACGAGGCTGCGTTACACGGCATGGACTATGGTCTTTACTTTTACACCTATGCGACAGAGATGAGCGAGGCAAAGCAGGAAATAGAGGGCTTTTTACAAGCGATCAAAGGTCTTAAACCGACGCTTCCGGTTGTTATTGACACGGAGGACGCAGACAAATGGCGCACGCGCCATGGTAATCCATCCTGGCGAATGCTTGCTGACATGCTTTATATGCAGCTTGAAAAGATTGAAAAAGCCGGCTATTACGCTATGTACTACGCGAGCAGATACTGGGTGGACAATCTACTGGCCAAGCGCCCGGACTTAAAGCGATTTGACTTGTGGCTTGCGCACTGGGATATCGCCGCTCCATCCATGCCGTGTGGCGTATGGCAGTACACAAGCGGCGGTCCGAAGTACGGAGACGGGATTGATCGCAGTGATCTTAATGTTGGCTATGTCGACTATCCAGCTCTCATCAAAAAGGCTGGTCTAAACGGCTGGCCAAAAGCAGAGCGTCCGGTTATCGCCGCCGATGATACTAAACCAGTTACAAAACCGACTCCGAAAAACAACACTATTGCAGGTGCTGTTTTTGACAAGTATGAGAATGCCACTTTCATCTTTGGTGCTGCTACTCATGTTCGTACTCTGCCGACGACAGACAGCCAAATTGTCGCAACCTATGACATTGGCGAAAGCGTAAAGTACGATCAAGTATATATCGGTAACGGATACGTGTGGATTAGTTACATTGGCCAGAGTGGTAACCGCCGTTTCTGTGCTTGTCGCACGTATCGCAACGGCAAGCGTGGAGAAGCTTGGGGAACTTTTAAGTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7hFHn) rather than this protein.
PDB ID
7hFHn
Method AlphaFoldv2
Resolution 89.17
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50