Protein

Protein accession
A0AA49X3Z3 [UniProt]
Representative
o3Q8
Source
UniProt (cluster: phalp2_529)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MAKPVIDISAYQHSRDIDYDTLSAAISGAILRVGFTGWGTGNSYHKDAEFENHYRELKKRGVPIGAYWYSCADTVAEGTAEANACYEMGLKGKTFELPIYWDTEDNHHQRPASSETLTATGRAFCKRLEELGYYVGIYASSSWLYTELNMAALSDIDVWVAHYGVSKPSYTGAYGMWQYTSSGRLPGYSGGLDLNVMYHDYPAIIRKAGLNGFPATSQKDLQSKPAPQPQPKPKTTPDVAGARFDKFESATFVFGTATNVRALPSTTSSIVAVYRVGESVKYDRVYVGNGYVWISYIGGSGIRRYCAVRTYQNGTRGETWGSFR
Physico‐chemical
properties
protein length:324 AA
molecular weight:35852,6 Da
isoelectric point:8,17
hydropathy:-0,40
Representative Protein Details
Accession
o3Q8
Protein name
o3Q8
Sequence length
321 AA
Molecular weight
36018,48080 Da
Isoelectric point
9,42110
Sequence
MNPIFGIDVSKWQGIFNFAKAKSEGVKFAILRAGYTGSLDGISKVKDSKFELFYKNAKANDILVGAYWYSRATTYEAGKKEAEYMYENCLKGKQFEYPIYIDIEDTKYQIKAGKKSVTEAIKGFCEYLEPKGYYVGIYANSNWFKNYIDTDSLKRYDKWIANWGKSKPTSPEAGMWQFGGETNKIRSNKIAGVTCDQNYAYKDYPGIMIQKGINGYKKIEETSKLDTIPPISSSDTANSSQKPIVDINPSPSLKVGDKVQIIDFGNSQASGKGKVAGGKGYKRYITKIYNGQAFPYQVGNKGKTDSKNTTGFYKEKSLKKV
Other Proteins in cluster: phalp2_529
Total (incl. this protein): 73 Avg length: 307,2 Avg pI: 7,68
Protein ID Length (AA) pI
o3Q8 321 9,42110
10H3U 329 8,77874
10IRI 324 8,03400
15Lo0 329 8,77307
15u2f 329 8,38806
1cC03 272 6,74630
1gB3J 272 7,98281
1mMBM 266 4,73136
21iVk 280 9,46655
21oB2 324 8,56580
24CHu 328 9,25007
24DUS 307 9,42207
2VmDY 324 8,70718
36nHt 324 8,85339
3Pwmt 327 9,12139
3TDBi 279 9,53076
3TExv 349 8,52648
3TKBs 263 8,51964
3VJEL 280 9,43767
3camU 304 9,57112
3dNGf 372 9,39235
3dSF6 268 9,17258
3g9MM 372 9,44476
3gaS6 317 8,88911
3itSW 273 9,34568
3mrR9 326 8,81981
3nvzw 266 4,73136
3tGmr 266 4,73136
3tUgX 266 4,79996
3tvsm 326 8,96164
3uXtC 266 4,79996
3ug0J 326 8,90117
3wa4L 266 4,73136
3yCPV 266 4,73136
3yeSw 324 8,95990
3yj3t 266 4,79996
4L5fK 280 9,41910
4yumS 323 7,46139
5LBHa 221 4,78177
5Rbsd 329 8,35654
5VN9g 326 9,07871
5VoOE 326 8,81981
5Z4PF 329 8,78441
5oik 267 5,52739
62D1G 326 9,07871
63PVb 329 8,77874
64tQR 336 8,03039
66KYu 336 8,31663
6bhH0 326 8,97311
6cGCQ 329 8,77874
6ecP8 336 8,03039
6fCW9 326 8,81981
6hg6m 329 8,36144
6jMSm 329 8,95351
6keP8 329 8,09009
6lqEv 329 8,77307
6my9R 329 8,66721
6nqAJ 329 8,54923
6vui5 326 8,61944
71cKD 266 4,73136
83y1 324 8,80846
86du2 371 4,91512
87yzp 272 6,24362
885t9 386 6,75551
888jf 331 8,50378
8bA6U 266 4,74261
8f3D8 266 4,71999
8kQnx 266 4,71982
8kTRB 194 4,69418
8qMGX 386 6,23674
8rocx 266 4,78899
BXAC 266 4,78899
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_31512
3WNwM
 280 63,6% 245 4.958E-122
2 phalp2_6199
5X5xO
 102 45,7% 221 1.318E-79
3 phalp2_3425
3TK4D
 923 50,6% 217 2.177E-75
4 phalp2_10110
c1k0
 16 34,2% 295 2.544E-68
5 phalp2_26548
858CP
 728 38,5% 241 4.997E-63
6 phalp2_23789
19iit
 3 38,2% 222 3.780E-58
7 phalp2_1334
14J9Z
 159 36,5% 312 7.052E-58
8 phalp2_2537
6a7No
 192 40,9% 222 2.054E-53
9 phalp2_15589
2brBA
 13 37,0% 216 2.804E-53
10 phalp2_10747
3nEcV
 19 30,1% 328 2.475E-52

Domains

Domains [InterPro]
GH25
Unannotated
Representative sequence (used for alignment): o3Q8 (321 AA)
Member sequence: A0AA49X3Z3 (324 AA)
1 321 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Firmicutes phage HS11
[NCBI] 		3056393 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OQ890319 [NCBI]
CDS location
range 8549 -> 9523
strand -
CDS
ATGGCAAAACCGGTAATTGACATCTCCGCCTATCAGCATTCGAGGGACATTGACTACGACACGCTGTCTGCAGCCATCTCCGGCGCAATACTTCGTGTGGGATTCACGGGATGGGGAACAGGAAATTCATACCATAAGGATGCTGAATTTGAAAATCATTATCGAGAGTTAAAAAAGCGTGGCGTCCCGATTGGCGCGTACTGGTACTCCTGCGCCGATACGGTCGCAGAAGGAACGGCAGAGGCAAATGCTTGCTATGAAATGGGACTTAAAGGAAAGACTTTTGAGCTACCCATTTACTGGGATACGGAAGACAACCATCACCAGCGGCCGGCGTCGAGTGAAACGCTTACCGCAACAGGGCGCGCTTTTTGTAAGCGTCTGGAAGAGCTTGGTTATTATGTGGGAATCTATGCTTCTTCTTCCTGGCTTTACACAGAGCTCAATATGGCAGCACTTTCAGATATTGATGTATGGGTAGCGCACTACGGCGTTTCAAAACCATCCTACACCGGCGCCTACGGGATGTGGCAGTATACCTCATCCGGACGTCTACCGGGGTACAGCGGGGGGTTAGACCTTAACGTAATGTACCACGACTATCCGGCAATTATCCGAAAAGCAGGGTTAAATGGCTTTCCGGCAACAAGCCAAAAAGACCTGCAATCAAAACCTGCACCGCAACCGCAGCCAAAACCAAAGACGACGCCGGATGTTGCTGGGGCGCGGTTTGATAAGTTTGAGAGTGCTACCTTCGTTTTTGGCACAGCCACCAACGTCCGTGCGCTGCCGTCAACGACAAGCTCCATCGTTGCCGTCTACCGTGTAGGGGAGAGTGTCAAGTATGACCGCGTGTATGTTGGTAACGGCTATGTGTGGATCTCGTATATCGGCGGCAGCGGAATTCGTCGCTATTGTGCGGTGCGGACGTATCAGAATGGAACACGCGGTGAAACGTGGGGAAGTTTTCGTTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (o3Q8) rather than this protein.
PDB ID
o3Q8
Method AlphaFoldv2
Resolution 89.33
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50