Protein

Protein accession
A0AA49IM57 [UniProt]
Representative
40uRC
Source
UniProt (cluster: phalp2_25234)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MAVTYETKYNSPNYTPAASVPAVYGMARKVEYITIHHWGAFGQSHSGVVSYLCRPNGNTSAHYVISGKVATCIVDPDNAAWHAGHATGNARSIGLELRPEADATTYATAAEVIADLREVYGNVPLVPHKKWHNTACPGKWDLAKLDKMAKAITAKRKAAKAPAKPAKAPAKPVAKPAPKPAPAKEAPVAKKENVKERDVWAYKPASMDADAYRILRDAAADAKAAKELAAEAVRLLKSLGAK
Physico‐chemical
properties
protein length:242 AA
molecular weight:25844,4 Da
isoelectric point:9,60
hydropathy:-0,36
Representative Protein Details
Accession
40uRC
Protein name
40uRC
Sequence length
240 AA
Molecular weight
25969,40640 Da
Isoelectric point
9,46198
Sequence
MAVTYETRYSSPNYTPAASVPAVYGMARKVEYITIHHWGLTGQSHAGVVNYLCRANGNTSAHYVISGLLATCIVDPDNAAWHAGHATGNARSIGLELRPEATALDYQGAAEVIADLRAVYGNVPLVPHKKWHATACPGKWDLAKLDRMAKAITAARKAPAKPASKPAPKPAPIVKEPAVATDPKDNRKEYNVWAYRYGKVDPRQVFSILLDAARDAKEARETAQANAVKLDKILAHLGIK
Other Proteins in cluster: phalp2_25234
Total (incl. this protein): 5 Avg length: 258,6 Avg pI: 7,94
Protein ID Length (AA) pI
40uRC 240 9,46198
A0A2H4P9I7 286 5,48430
A0A514A4J4 286 5,47964
A0AA49IJY3 239 9,67021
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_7901
8LrgT
 13 50,2% 169 2.698E-60
2 phalp2_31556
4fe7g
 22 47,5% 185 2.997E-58
3 phalp2_15294
1dl82
 2 36,9% 211 1.436E-54
4 phalp2_16559
7s5Uq
 12 48,4% 161 2.150E-49
5 phalp2_13806
716PV
 1 37,7% 159 5.976E-36
6 phalp2_13827
7cMO8
 12 42,1% 159 3.433E-34
7 phalp2_28005
6RLJZ
 8 39,1% 148 1.054E-32
8 phalp2_38221
7wekT
 2 34,2% 184 1.717E-24
9 phalp2_33401
6T3Pt
 1 35,7% 151 4.312E-18
10 phalp2_32194
6VJSL
 13 28,1% 199 1.942E-12

Domains

Domains [InterPro]
Ami2
Disordered region
Representative sequence (used for alignment): 40uRC (240 AA)
Member sequence: A0AA49IM57 (242 AA)
1 240 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Arthrobacter phage VroomVroom
[NCBI] 		3049371 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OQ938592 [NCBI]
CDS location
range 17771 -> 18499
strand +
CDS
ATGGCTGTTACCTACGAGACCAAGTACAACTCCCCGAACTACACTCCGGCCGCTTCCGTCCCGGCCGTCTACGGCATGGCCCGCAAGGTCGAGTACATCACGATCCATCACTGGGGCGCCTTCGGCCAGTCCCACTCCGGCGTCGTCTCCTACCTCTGCCGTCCGAACGGCAACACCTCGGCCCATTACGTGATCTCCGGCAAGGTCGCCACGTGCATCGTCGACCCGGATAACGCCGCCTGGCACGCCGGACACGCCACCGGCAACGCCCGCTCGATCGGCCTGGAACTCCGCCCGGAGGCCGACGCCACCACGTACGCCACGGCCGCCGAGGTAATCGCCGACCTCCGCGAGGTCTACGGCAACGTCCCTCTCGTGCCGCATAAGAAGTGGCACAACACCGCCTGCCCTGGCAAGTGGGATCTCGCCAAGCTGGACAAGATGGCCAAGGCGATCACCGCCAAGCGCAAGGCGGCCAAGGCACCGGCCAAGCCCGCCAAGGCACCGGCCAAGCCCGTCGCCAAGCCCGCACCCAAGCCCGCACCCGCCAAGGAGGCACCCGTGGCCAAGAAGGAAAACGTCAAGGAGCGCGACGTCTGGGCCTACAAGCCCGCCAGCATGGACGCCGACGCCTACCGCATCCTCCGCGACGCAGCGGCCGACGCCAAGGCGGCCAAGGAACTCGCTGCCGAGGCCGTCCGGCTGCTCAAGTCGCTCGGCGCTAAGTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0009254 peptidoglycan turnover biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0071555 cell wall organization biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.5.1.28 None Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00001561

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (40uRC) rather than this protein.
PDB ID
40uRC
Method AlphaFoldv2
Resolution 79.25
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50