Protein

Protein accession
A0AA46RZK2 [UniProt]
Representative
4lF8s
Source
UniProt (cluster: phalp2_34911)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKTSEKGLDLIKQFEGFKDYVYMCPAGKPTIGYGHVIDSKLVALTKAAPRMTKEKAEQLLKKDVKEAENAINSFVMISLKQSQFDALVSLIYNWGAYNFKISNGLRKLNAGDYNGASDEFFGKIRGVVTVNGQFSNGLYRRRQAELELWQS
Physico‐chemical
properties
protein length:151 AA
molecular weight:16998,3 Da
isoelectric point:9,36
hydropathy:-0,37
Representative Protein Details
Accession
4lF8s
Protein name
4lF8s
Sequence length
223 AA
Molecular weight
24799,15460 Da
Isoelectric point
8,66934
Sequence
MNFISIISLIKKFVSIFKIFNTVKNVTDINTTEAKENVKTVVEVVKEVVTPNTNTVDTSSVSDVPTATEPVEEPYMYTPSNKCYDMIKKFEGFRSKPYKCPAGIPTIGYGSTFYENGTKVTMKDAPITEEKATELLKNVVNDFAKEVNKLIKVKVTQNQFDALVDFAYNLGIGNLGNSTLLKKVNASAFAEAADQFPRWNKAGGVILEGLTKRRNAERELFLS
Other Proteins in cluster: phalp2_34911
Total (incl. this protein): 21 Avg length: 174,6 Avg pI: 7,77
Protein ID Length (AA) pI
4lF8s 223 8,66934
1RFOo 191 4,83532
1SkvJ 191 5,20210
27hrg 163 8,89291
3AqIv 149 9,04596
3cwa9 216 6,00768
3ouGo 191 4,85635
4TNL3 191 4,85635
6Ni3i 193 5,23427
6WAun 149 9,17522
8Cy6K 191 4,85635
QvvE 210 8,61499
bY8X 149 9,44831
A0A2I7QL28 158 9,19185
A0A2I7QL74 158 9,19185
A0A2I7QLB9 158 9,19185
A0A2I7RHT6 158 8,77249
A0AAE7Y4W6 158 9,00838
A0A6J5MZG8 149 9,29894
A0A6J5RQ80 169 9,40312
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_4451
31DIk
 4919 62,7% 145 1.450E-67
2 phalp2_28113
7zmZV
 50 60,4% 144 1.357E-57
3 phalp2_6830
8n5Jv
 121 54,0% 150 1.869E-54
4 phalp2_2632
6RhYr
 14867 55,9% 143 4.325E-53
5 phalp2_22738
7ZWXa
 59 58,3% 149 7.304E-52
6 phalp2_32792
2snIK
 45 50,0% 142 4.807E-51
7 phalp2_37325
8t1Gv
 89 49,6% 157 4.328E-50
8 phalp2_31105
1YRHZ
 456 52,7% 148 1.519E-49
9 phalp2_39262
3ZDlT
 646 56,0% 141 1.871E-48
10 phalp2_33221
5jbqV
 447 48,6% 144 1.683E-47

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 4lF8s (223 AA)
Member sequence: A0AA46RZK2 (151 AA)
1 223 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Megaira polyxenophila phage MAnkyphage_25.80
[NCBI] 		2981581 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OP381185 [NCBI]
CDS location
range 21725 -> 22180
strand +
CDS
ATGAAAACATCAGAAAAAGGACTTGATCTAATCAAGCAATTTGAGGGATTTAAGGATTATGTCTATATGTGTCCTGCTGGGAAACCAACAATAGGATATGGTCATGTTATAGACTCCAAATTAGTTGCGCTTACAAAAGCCGCTCCTCGTATGACAAAAGAAAAAGCAGAACAACTACTTAAAAAAGACGTTAAGGAAGCGGAGAACGCTATAAATTCTTTTGTAATGATATCACTCAAACAAAGTCAATTTGATGCTCTAGTAAGCCTTATATACAACTGGGGGGCATATAATTTTAAAATAAGCAACGGACTTAGAAAATTAAATGCTGGAGATTATAACGGGGCTTCTGATGAGTTTTTTGGAAAGATTAGGGGCGTTGTAACAGTAAATGGCCAGTTCTCTAATGGTTTATATAGAAGAAGACAAGCAGAGTTAGAATTATGGCAATCTTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (4lF8s) rather than this protein.
PDB ID
4lF8s
Method AlphaFoldv2
Resolution 83.28
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50