Protein

Protein accession
A0A9N6YJ85 [UniProt]
Representative
1fTML
Source
UniProt (cluster: phalp2_30973)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MKPQSKLIGGSAAAVILGASALMVANEGVVLRTYADPVWGERVPTACVGETGPHIRMGQTFTHEQCMQMLGRRVEVSWSRIERCLQRPVPVNVAVSLVDLGYNVGEQAVCSSTLVRQINSGQPPAVYCEQFMRWTFVGGRDCRDPKNNCRGIVTRRDHARSLCLGNTPVPG
Physico‐chemical
properties
protein length:171 AA
molecular weight:18652,4 Da
isoelectric point:9,08
hydropathy:-0,13
Representative Protein Details
Accession
1fTML
Protein name
1fTML
Sequence length
231 AA
Molecular weight
24657,22580 Da
Isoelectric point
9,09528
Sequence
MTPKTDAAVQAVSYAGAGTSVLAGLTLTDIGVIIGIATAILTLLFNVIYQVRKDRREQRLYKLEVERLSGKSQRGNAKVGAVVGAGLLAVVAGIATPLIKHFEGQRLVAYSDVVGVPTICAGITEDVKLGDVATPEQCDQRLQADLRRRLAGLQGCIHKELTPNQWAAVLSFAYNVGVPAVCGSTLVSMINAGASPSQWCAQLDRWVYAGGQKLAGLERRRAAERELCERQ
Other Proteins in cluster: phalp2_30973
Total (incl. this protein): 10 Avg length: 192,9 Avg pI: 8,77
Protein ID Length (AA) pI
1fTML 231 9,09528
35DWx 247 9,42923
7wlrY 228 5,56138
fK8s 247 9,26503
A0A2P0ZLK0 166 8,94165
Q0E618 160 9,23518
A0A0B4UHR3 159 9,09663
A0A2P0P9W0 160 8,77210
A0A6C0R196 160 9,23511
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_26525
83EoO
 66 48,6% 146 1.482E-43
2 phalp2_5806
4ZKl2
 35 38,1% 173 6.471E-29
3 phalp2_7028
8i7gz
 89 37,5% 152 7.762E-28
4 phalp2_8252
7B99h
 46 36,5% 197 7.762E-28
5 phalp2_23830
1lpLy
 242 40,6% 160 1.444E-27
6 phalp2_24123
7oopP
 467 33,0% 221 4.995E-27
7 phalp2_23545
7lES7
 2 29,6% 283 1.266E-26
8 phalp2_3556
4E0oc
 53 40,0% 160 1.318E-24
9 phalp2_16574
7xiDE
 15 36,8% 160 2.447E-24
10 phalp2_12784
8jI3j
 17 36,5% 178 1.357E-22

Domains

Domains [InterPro]
Disordered region
GH24
Representative sequence (used for alignment): 1fTML (231 AA)
Member sequence: A0A9N6YJ85 (171 AA)
1 231 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Cyanophage Cy-LDV1
[NCBI] 		2916630 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK059895 [NCBI]
CDS location
range 44114 -> 44629
strand +
CDS
GTGAAGCCGCAGAGCAAGCTGATCGGCGGAAGCGCCGCAGCGGTCATCCTTGGCGCGTCTGCGCTGATGGTGGCAAACGAGGGCGTGGTGCTTCGGACTTACGCGGACCCGGTATGGGGCGAGCGCGTACCGACTGCCTGCGTGGGTGAGACAGGTCCGCACATTCGCATGGGCCAGACCTTCACGCACGAGCAGTGCATGCAAATGCTCGGCCGCCGGGTCGAAGTGTCGTGGTCGCGCATCGAGCGCTGCCTACAGCGTCCGGTGCCGGTCAACGTGGCCGTCTCGCTGGTTGACCTTGGCTACAACGTCGGCGAGCAAGCTGTGTGCAGCAGCACGCTGGTGCGACAGATCAACAGTGGGCAGCCGCCGGCGGTCTACTGCGAGCAATTCATGCGCTGGACATTCGTCGGCGGCCGTGACTGCCGCGACCCCAAGAACAACTGCCGCGGCATCGTGACGCGACGCGATCATGCGCGCTCTCTGTGCCTGGGCAACACGCCCGTCCCGGGCTAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (1fTML) rather than this protein.
PDB ID
1fTML
Method AlphaFoldv2
Resolution 85.57
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50