Protein

Protein accession
A0A9E8JX62 [UniProt]
Representative
6Ew8q
Source
UniProt (cluster: phalp2_33347)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MNSIRQKMIASFLAAGIGASGAFVAYDLTLPSEGLEQKVYIDPVGLPTVCVGHMDKSLKLGQTFTIEQCMGMFAKDWKKHQKQLDSVVKVPYKSEWQREALTDFTFNLGIGNVQSSTLLSLINQNKHTEACRQLTRWVKGKVKGKMVTLKGLVTRRDKTMPYCLGELSWDKQQEFKQFEAEYNEAIKRQKESN
Physico‐chemical
properties
protein length:193 AA
molecular weight:21901,1 Da
isoelectric point:9,30
hydropathy:-0,43
Representative Protein Details
Accession
6Ew8q
Protein name
6Ew8q
Sequence length
185 AA
Molecular weight
20583,72850 Da
Isoelectric point
8,91535
Sequence
MGVRITDSLKKKILVALVAAGISGPSAYVATQLTVPSEGFELVVYADPVGLPTVCIGHMDKKLVVGTKVTEEYCVRTFVEDWNKHEKLLNGVVKVDYKSEWMYGALTDFTFNKGIGNVQSSTLLKLLNNKKYDQACEQLSRWVYAKKNGVAVVLPGLVIRASKQYSYCMGIEPADYKQTMSRYLE
Other Proteins in cluster: phalp2_33347
Total (incl. this protein): 73 Avg length: 185,4 Avg pI: 8,92
Protein ID Length (AA) pI
6Ew8q 185 8,91535
1IrPL 152 8,64439
1KIb0 190 7,62435
1KSoG 188 8,89801
1LBan 188 9,37482
1LwO9 191 9,03603
1oOBL 185 8,89433
1oOaW 185 9,15749
2I1A7 174 10,02595
2WFlb 194 9,21352
2X21h 190 9,05744
2gpim 190 8,89440
2mEwh 200 9,11997
3X8c0 178 9,13486
3dHhb 188 9,17051
3dKdu 188 9,08361
3elE9 188 9,34355
3fEjq 185 9,04616
3iFlk 188 9,25510
40whv 189 8,83818
4CAmr 188 9,08368
4Hsls 152 9,03539
4KZeu 188 9,35116
4NLiE 190 8,63369
4QuUD 195 9,44019
4U7o2 192 8,91541
4XAJj 190 9,06569
4XTEg 185 9,18483
4XTcI 192 8,94997
4Xur3 185 9,17116
4XvdQ 185 9,07098
4YiiN 173 8,81355
4f1Vg 190 9,30055
4f26M 191 8,64400
4gHjp 194 9,07259
4gHwC 188 8,80859
4jOCR 194 9,45650
4qRbY 186 9,01224
4qzmP 190 8,85591
4r4at 186 9,18483
4tRhZ 189 9,14466
4y1AT 189 8,75669
4y1Lg 184 8,90432
5jivC 161 9,46894
63JOU 171 9,54894
6DezD 191 8,78706
6QyTI 182 8,60326
6RRDm 194 9,34316
6Rzhe 175 9,31647
71zCT 184 8,58508
7DXns 189 8,93804
7DriA 176 9,03384
7IDY8 190 9,19862
7Vkfn 189 8,28794
7Y9EK 184 8,61190
7uQfd 176 8,40663
7vAok 177 8,99896
7zfkv 178 8,71743
8bjZg 184 7,60627
8jHik 197 9,09670
8kaeb 193 6,43363
8lQYM 190 8,54014
8m8QE 188 9,04596
8oown 190 8,77655
8pTiF 188 8,93785
8w4BS 176 9,03384
PGhP 188 7,59360
PVPq 183 8,59397
QI4C 190 8,96144
fsyN 185 8,93785
A0A345BRQ0 171 8,40102
A0AAF0BXT0 188 9,25510
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_9410
8Hj1q
 5109 38,5% 127 1.451E-42
2 phalp2_26525
83EoO
 66 36,6% 161 4.168E-40
3 phalp2_27241
3VsL8
 2 32,3% 167 4.168E-40
4 phalp2_22286
7A6Fj
 714 29,9% 167 1.198E-34
5 phalp2_4305
8aoFg
 2477 29,6% 152 7.880E-34
6 phalp2_6830
8n5Jv
 121 34,0% 144 1.476E-33
7 phalp2_8252
7B99h
 46 32,9% 185 1.328E-32
8 phalp2_2632
6RhYr
 14867 35,3% 133 3.060E-31
9 phalp2_37325
8t1Gv
 89 32,5% 163 9.627E-30
10 phalp2_30676
6Q25R
 25 32,1% 143 1.181E-28

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 6Ew8q (185 AA)
Member sequence: A0A9E8JX62 (193 AA)
1 185 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Pseudomonas phage vB_PaeM_M1
[NCBI] 		2995601 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OP714164 [NCBI]
CDS location
range 66915 -> 67496
strand +
CDS
ATGAACAGTATCCGACAAAAAATGATTGCCTCTTTCTTAGCAGCCGGTATTGGCGCTAGTGGAGCCTTTGTTGCTTATGATCTTACTTTACCAAGTGAAGGATTAGAACAAAAGGTTTACATTGATCCTGTGGGACTTCCAACAGTTTGTGTTGGTCACATGGATAAGTCTCTCAAGCTTGGACAAACATTCACCATCGAGCAGTGCATGGGTATGTTTGCTAAGGATTGGAAGAAGCATCAGAAGCAATTAGACAGTGTTGTGAAGGTTCCTTACAAATCAGAGTGGCAGCGTGAGGCTCTTACAGACTTCACGTTCAACCTAGGCATTGGTAATGTCCAGAGCAGTACCCTACTATCCCTCATCAACCAAAACAAGCACACAGAGGCTTGTAGGCAGCTTACACGCTGGGTGAAGGGTAAGGTTAAGGGGAAGATGGTTACTCTTAAAGGACTTGTCACTAGGCGTGATAAAACAATGCCTTACTGCCTTGGTGAGCTGAGTTGGGATAAACAGCAAGAATTCAAACAATTTGAGGCAGAGTATAATGAAGCTATTAAAAGACAAAAAGAAAGTAATTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (6Ew8q) rather than this protein.
PDB ID
6Ew8q
Method AlphaFoldv2
Resolution 96.68
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50