Protein

Protein accession
A0A9E7NPG1 [UniProt]
Representative
8ke1T
Source
UniProt (cluster: phalp2_11817)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 97% (predicted by ML model)
Protein sequence
MSFTKVIAFEEGFRAKPYKCSAGYPTIGYGIKLANKNANIDHFDCEIPEPVAHLWLESHALREEAKLCQYAWFIDQRKDVQDILVSMCYQLGLNGLLGFKKMIAALCVNDMETAASEALDSKWASIDSQNRAQRHARVIKGESIDDVYSGLI
Physico‐chemical
properties
protein length:152 AA
molecular weight:17077,4 Da
isoelectric point:5,79
hydropathy:-0,16
Representative Protein Details
Accession
8ke1T
Protein name
8ke1T
Sequence length
75 AA
Molecular weight
8352,41450 Da
Isoelectric point
4,79166
Sequence
MSWFADLDAVRQDAIVNLCFNLGLTRLMGFKNAVGAMAVGDYEKAADEFLDSRWANQVGQRALDVAHMIRTGEYP
Other Proteins in cluster: phalp2_11817
Total (incl. this protein): 134 Avg length: 88,2 Avg pI: 6,19
Protein ID Length (AA) pI
8ke1T 75 4,79166
10TCv 74 9,50704
13SvD 99 4,66292
15Ssc 141 5,01925
16oo0 86 5,07239
1Eko 64 8,38593
1GxgZ 101 5,19545
1Muzy 84 10,26132
1N1pt 58 4,71618
1OmO 100 4,72977
1SsQK 57 6,35837
1V69l 82 4,56976
1pSQH 59 10,04013
1t60A 71 6,51207
1tvyj 67 5,34505
1uKQ 99 4,85907
1ut9p 84 4,54504
1wON1 84 5,77515
1xtxs 57 9,69374
2149m 64 6,81996
22ogk 67 9,98436
22zwR 64 9,30029
23nzw 140 5,27360
26ALE 94 6,91210
2A0hh 71 4,66963
2AHSd 89 8,54524
2I2wh 82 8,13702
2IjvC 141 5,12144
2JLHp 89 4,80661
2JdxI 87 4,89534
2L77a 60 10,14702
2Mkm7 69 6,52809
2NchN 93 4,98895
2O0Fu 79 4,53185
2O8Hc 81 5,07137
2OoQu 140 5,09109
2Pj2r 66 9,67846
2Qahq 141 5,26417
2R20s 83 4,79860
2RPRc 65 6,76398
2ZHo7 97 4,66571
2eVkB 84 5,15339
2mj0Q 92 4,94143
2vGkg 66 4,88761
2xG89 62 5,28417
2xHuo 139 5,10200
2yo9r 70 4,76160
2ythg 74 6,78762
2zY5p 73 6,46182
31igW 96 4,65804
35D43 108 5,21085
3BykH 110 4,26477
3JuM7 77 4,79024
3Jy01 75 4,53765
3P1m2 71 4,25067
3QI7O 98 4,78308
3QpIB 85 5,07131
3RF1G 62 8,34326
3RcdI 78 4,60068
3Rrat 76 4,68816
3V9Q2 96 5,37841
3YiRM 99 4,57778
3oozC 87 9,73706
3xiVK 61 5,17067
40NSY 94 4,36509
4AXtG 96 4,91705
4EuRK 91 4,54123
4NFJu 104 8,15488
4OYox 86 4,70879
4TSBd 78 4,44506
4UJAc 80 5,35022
4USMC 128 9,13196
4WQJ7 64 9,59871
4r26X 99 5,07762
4tc3c 91 4,54123
4v1vS 91 9,68368
5A43k 64 6,45472
5Affc 91 4,79235
5Ilcf 61 9,65280
5qWdn 141 4,79820
5sgzL 98 4,94644
5t8RH 141 5,47561
6EcXp 62 4,84737
6G9Ub 93 4,39686
6NPlG 143 5,23211
6VHKF 90 8,77249
7004 69 6,40316
75UmE 97 9,17200
7CPpa 53 9,81397
7CwMR 90 5,03101
7TFea 69 4,64610
7TGPk 75 4,65923
7oKqc 89 8,94217
878wn 168 5,94765
87AkF 89 9,42774
8Adm 88 8,54491
8AjFq 93 4,51804
8AuSg 95 9,83828
8BJGQ 64 8,34261
8BMw3 54 10,08339
8BaWU 68 5,38972
8DJtP 71 6,71623
8DQL5 59 10,59088
8Ddp3 81 5,04585
8DlwY 91 6,31154
8Dq3c 91 6,58442
8E0q2 81 10,56548
8GHrD 70 4,96934
8GSKR 56 9,89475
8Qwp 169 5,66966
8d8id 168 5,94765
8ysbh 90 7,70205
8zaxO 98 4,27773
AiO4 65 5,76139
Ay7g 56 5,25621
Dj6M 99 4,77711
Ds2Z 70 4,94564
PyWs 130 7,17248
WMex 88 5,14901
XY2n 140 5,13548
Z2nW 96 6,11198
lnio 140 4,59773
nEwk 93 6,88379
qVN9 65 4,88749
qWDD 70 4,94564
r2ru 85 5,86780
rJ8X 87 6,79666
sV0q 83 4,91114
tJVP 84 5,06688
taWZ 76 4,76017
vNEt 73 6,79296
w7II 70 4,94564
yLIR 82 4,69208
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_23657
8HjXQ
 36 51,2% 78 1.048E-30
2 phalp2_25441
2RHwi
 57 48,5% 70 1.439E-30
3 phalp2_24916
8DwFO
 101 61,4% 57 5.943E-28
4 phalp2_18224
4OOGY
 8 51,7% 58 2.459E-25
5 phalp2_473
8zCRl
 299 43,2% 67 1.201E-24
6 phalp2_4036
185uE
 1 40,5% 74 1.201E-24
7 phalp2_22992
3CfKl
 406 35,7% 70 5.869E-24
8 phalp2_36345
lSw4
 8 49,1% 61 7.429E-23
9 phalp2_11147
5zMFW
 8 45,2% 73 1.775E-21
10 phalp2_30560
5E0Xj
 12 34,3% 67 2.438E-21

Domains

Domains [InterPro]
Unannotated
Representative sequence (used for alignment): 8ke1T (75 AA)
Member sequence: A0A9E7NPG1 (152 AA)
1 75 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated

Taxonomy

  Name Taxonomy ID Lineage
Phage Vibrio phage vB_VnaS-L3
[NCBI] 		2961683 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
ON714422 [NCBI]
CDS location
range 10602 -> 11060
strand -
CDS
ATGAGCTTTACAAAAGTAATCGCATTCGAAGAAGGATTTAGAGCTAAGCCTTACAAGTGCAGTGCGGGATATCCGACAATTGGATACGGAATCAAGCTAGCAAACAAAAACGCCAATATTGACCACTTCGATTGCGAAATCCCTGAGCCTGTGGCGCACTTATGGTTGGAGTCTCACGCACTGAGAGAAGAGGCCAAGCTCTGCCAATACGCATGGTTTATCGACCAGCGGAAAGACGTACAGGATATTCTAGTTTCAATGTGCTACCAGCTTGGCTTAAACGGCTTGCTAGGATTCAAAAAGATGATTGCCGCGCTATGTGTCAATGATATGGAAACGGCCGCTAGTGAGGCGCTAGATTCGAAATGGGCGAGTATTGATTCACAAAACCGCGCACAACGTCACGCACGAGTAATCAAAGGAGAGTCTATTGATGATGTTTATAGCGGTCTTATTTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (8ke1T) rather than this protein.
PDB ID
8ke1T
Method AlphaFoldv2
Resolution 96.08
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50