Protein

Protein accession
A0A9E6N9F2 [UniProt]
Representative
6rv4w
Source
UniProt (cluster: phalp2_36067)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MLNGIDISGYQDNDAGSAVPADFVIVKATEGTTYVSSHCDPQVQGARKAGRLVGVYHFASGIPGAEAEADFFVRQVRGYIGQAILVLDWEANAIRKGPAYALAFLNRVHALTGVKPLIYMSTSVVNGYDWSAVVAADYGLWSAAYGSNPRRTAYQAPSAPSVNHWGHPVLHQYGSNFYAGGRGPLDIDVFYGDAATWGKYAAVGGKGAPAPSKPAPAPSKPTAGKLDADGILGPATIKRLQHDLGTVEDGSISRPSLVVKALQARMNRQGFRGLNGKPLTVDGLGFAQDGKRYETVAAFQRYMGTPVDGIMSKPSSAVVKAAQRRMNRGHI
Physico‐chemical
properties
protein length:331 AA
molecular weight:35077,3 Da
isoelectric point:9,48
hydropathy:-0,19
Representative Protein Details
Accession
6rv4w
Protein name
6rv4w
Sequence length
382 AA
Molecular weight
41270,53070 Da
Isoelectric point
8,62692
Sequence
VRNHPLFLIDERRIIMAMNGIDISNYQHGINLSKVPCDFVICKATEGTTFVDKYCDGFMQQAMKLGKKVGVYHFASGKSSGKAEADFFLSHVQGYIGKAILILDWEAGAVAKGPAYAKEFLDRVKEKTGIKPMLYSYNNCINAYDWSTVKNADYGLWNAGYYAGDTIMGYNQNAPIKGGLGAWGSCAMYQYTSHGRIAGWSGNLDLDVFYGNTNAWDKFAGGSAGAGTSIAKPAPAPIPAVNPTNQSMKNAQIHINNFTGAGIPEDGKNGPKTRKGLIMALQTACNMDYSSGLTVDGKIGEKTNDARGLHYVKRGEKQYLVTFVEIGLTALGYYSGAVEAPGIFGGGLETAVDKFQNDTGLNNDKVAGRNVMDMILRKMGCI
Other Proteins in cluster: phalp2_36067
Total (incl. this protein): 74 Avg length: 337,1 Avg pI: 6,56
Protein ID Length (AA) pI
6rv4w 382 8,62692
13q6Y 280 8,14270
13q7k 281 8,95500
13yQc 274 8,06114
21v4R 314 8,92418
23E20 287 8,72123
23HW2 295 9,58176
23bWs 284 7,99539
23q8R 314 9,01315
23tW2 287 8,83644
23zNG 284 7,51687
24mB8 314 8,80118
3PVUZ 278 8,70808
3TFp0 314 9,01321
3TJif 349 4,68054
3WLHY 304 8,39773
3ZSh8 314 8,93256
3k7xo 349 4,70237
3oq6q 367 8,59681
3pCzx 367 8,45962
40YF7 314 8,66508
5KAwS 349 4,59995
5N5Pb 349 4,57397
5OT6f 349 4,50929
5OvnS 349 4,70237
5OwyD 349 4,59222
5SPw2 343 4,66361
5TCAU 349 4,66412
5UlO2 349 4,63575
5VdQH 349 4,69333
5W0z8 349 4,67259
5X6JW 349 4,61887
5XUnq 349 4,49860
5Xbyx 349 4,71146
5YuCs 349 4,66412
5YvOG 349 4,53918
5tJg7 333 5,16879
6004b 349 4,66145
60gKg 367 8,59681
60hpE 349 4,63575
60yp0 367 8,30425
62hOh 349 4,57397
631Tl 369 7,56200
64XqG 349 4,64280
67nix 349 4,67878
69j9e 349 4,61796
6YY85 349 4,66145
6YbSk 349 4,50929
6fWOl 349 4,54174
6hUpV 349 4,58380
6k7jI 367 8,03033
6kDk2 349 4,73392
6m5Zf 296 7,11490
6mBMv 349 4,50088
6pKTt 349 4,52776
6q8Zf 353 4,22629
6tggK 349 4,54004
6uHVa 352 4,17934
6unzM 367 8,27647
712W3 349 4,61796
7aQKb 326 6,08276
7g971 314 8,32269
7sxJF 353 9,14312
7y0y5 369 8,02472
80rxw 367 8,27350
82RwJ 340 8,91967
87Hiv 340 8,94642
8fzL1 312 9,01315
8luWK 369 6,98508
8pEOM 280 7,62202
8s6RD 367 7,52391
qdVg 349 4,56800
A0A6G5XZW6 345 9,12513
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_37341
8v6XY
 562 50,0% 236 9.801E-90
2 phalp2_4019
13DUc
 70 44,0% 268 4.683E-89
3 phalp2_30061
2NCcc
 23 36,8% 255 8.026E-51
4 phalp2_8460
169H9
 3 33,3% 291 2.755E-50
5 phalp2_39009
8i5mw
 7 33,0% 245 1.214E-37
6 phalp2_14288
3xQM7
 130 28,0% 388 3.437E-36
7 phalp2_37800
4CJpM
 1 31,0% 235 1.511E-30
8 phalp2_39458
4VDTp
 155 28,9% 363 8.178E-28
9 phalp2_1549
3LwuQ
 17 30,6% 303 4.903E-27
10 phalp2_17042
7nSW4
 41 26,0% 326 5.312E-26

Domains

Domains [InterPro]
GH25
PG_1
Representative sequence (used for alignment): 6rv4w (382 AA)
Member sequence: A0A9E6N9F2 (331 AA)
1 382 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF01471

Taxonomy

  Name Taxonomy ID Lineage
Phage Curtobacterium phage Penoan
[NCBI] 		2851076 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MZ333133 [NCBI]
CDS location
range 3125 -> 4120
strand -
CDS
ATGCTCAACGGCATCGACATCAGTGGCTACCAGGACAACGATGCAGGGTCGGCGGTCCCCGCTGACTTCGTGATCGTCAAGGCCACCGAGGGCACCACCTACGTGTCCTCGCACTGCGACCCCCAGGTGCAGGGAGCACGCAAGGCGGGGCGGCTGGTCGGCGTGTACCACTTCGCCTCGGGCATCCCCGGCGCTGAGGCCGAAGCGGACTTCTTCGTCCGCCAGGTCAGGGGCTACATCGGGCAGGCGATCCTGGTCCTGGACTGGGAGGCGAACGCCATCCGCAAGGGTCCGGCGTACGCGCTCGCGTTCCTGAACCGCGTGCACGCGCTCACGGGCGTCAAGCCGCTCATCTACATGAGTACGTCCGTCGTGAACGGCTACGACTGGTCGGCCGTCGTCGCCGCCGACTACGGCCTCTGGTCCGCCGCCTACGGGAGCAACCCGAGGCGCACCGCCTACCAGGCCCCGAGCGCCCCGTCGGTCAACCACTGGGGCCACCCGGTGCTGCACCAGTATGGGAGCAACTTCTACGCCGGGGGCCGTGGCCCGCTCGACATTGACGTGTTCTACGGGGACGCGGCGACGTGGGGCAAGTACGCGGCTGTGGGCGGCAAGGGTGCCCCGGCCCCGAGCAAGCCCGCACCCGCCCCGAGCAAGCCGACTGCGGGGAAGCTCGACGCGGACGGCATCCTCGGGCCTGCGACGATCAAGCGGCTGCAGCACGACCTGGGGACCGTTGAAGACGGGTCGATCAGTCGCCCGAGCCTCGTCGTCAAGGCGCTCCAGGCTCGCATGAACCGCCAGGGGTTCCGTGGCCTGAACGGCAAGCCGCTCACCGTGGACGGACTCGGGTTCGCCCAGGACGGCAAGCGCTACGAGACAGTGGCCGCATTCCAGCGCTACATGGGGACCCCCGTGGACGGGATCATGTCCAAGCCCTCCAGCGCCGTCGTCAAGGCTGCACAGCGGCGCATGAACCGTGGTCACATCTAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (6rv4w) rather than this protein.
PDB ID
6rv4w
Method AlphaFoldv2
Resolution 88.15
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50