Protein

Protein accession
A0A8S5VN42 [UniProt]
Representative
8pZP5
Source
UniProt (cluster: phalp2_40154)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 97% (predicted by ML model)
Protein sequence
MEIKGIDVSSWQGKPDWAKVSKSGVKFAILRIHQKSGIDESFEHNYKGCKSNGILIGGYKYSYALTSAQAIDEAENVISVLGGRGLDFPVFYDLEWAQQRSLGKQAIENIAVAFLTRIKKAGYKAGIYCNLDWYNNVLSDALKQYDCWIARYPADDNGTVQTRLKPSVGVGWQYSSKGKVPGISGNVDMDVFYKDYRDSNQKGETKMVKISNCGHDERGRYAGGKAGDQTGTEYQIMNWYSRPWLCVLRFNDAKIATMIADMATKAAQNNLIGYDQGTAGNSNDRYSFWRHLKASNYDPAQITIACESDCSASTAAIVKGAGYRLNNAKLKAVSIYLTTRNMRQALKNAGAKVLTDRKYLTSGDYLKAGDILLNDNHHVAIAVTTGAKASTLSTPTILSKTPKWVGKVTANKLNVRTWAGTENPQLKSYPVLAKGNLVDVCDTIKAKDKTDWYYIRIAGKYFGFASAKYICKV
Physico‐chemical
properties
protein length:473 AA
molecular weight:52314,9 Da
isoelectric point:9,36
hydropathy:-0,40
Representative Protein Details
Accession
8pZP5
Protein name
8pZP5
Sequence length
339 AA
Molecular weight
38311,09780 Da
Isoelectric point
8,80234
Sequence
MESRQMIIQSVMQVLKSKVDQETLDIVQDALTIELNRYEVQERTTELSVVDNSAVGMLRRYIATKRIEGKAEFTLKRYWEQNLQLICQESEQHHKALIFAQICAGAMPRKDKNMELKGIDVSSWQGKPDWPKVSNSGVKFAILRIHQKSGVDTSFEHNYKGCKSNGILIGGYKYSYALTSAQAIEEAENVISVLGGRGLDFPVFYDLEWAQQRSLGKQAIENIAVAFLTRIKKAGYKAGIYCNLDWYNNVLSDALKQYDCWIARYPASDNGSVQERLRPNVGVGWQYSSKGKVPGISGNVDMDVFYKDYRDSNQKGETKMVKISNCGHDERGRYAGGKA
Other Proteins in cluster: phalp2_40154
Total (incl. this protein): 3 Avg length: 427,7 Avg pI: 9,15
Protein ID Length (AA) pI
8pZP5 339 8,80234
A0A8S5QIA1 471 9,29313
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_30592
67VKs
 21 67,1% 225 1.106E-97
2 phalp2_35708
3PWv2
 29 36,7% 223 1.575E-34
3 phalp2_39103
2m4j4
 107 39,5% 215 2.081E-32
4 phalp2_23950
235xP
 13 40,6% 219 2.823E-32
5 phalp2_34702
2Vinc
 3 34,4% 218 1.031E-28
6 phalp2_22968
3mo9t
 23 30,7% 218 3.597E-17
7 phalp2_33489
7w448
 5 28,2% 244 3.747E-16
8 phalp2_9153
6wSxJ
 7 31,2% 224 1.274E-12
9 phalp2_5862
5yfd0
 6 26,6% 218 2.656E-06

Domains

Domains [InterPro]
Unannotated
Unannotated
GH25
Disordered region
Representative sequence (used for alignment): 8pZP5 (339 AA)
Member sequence: A0A8S5VN42 (473 AA)
1 339 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Herelleviridae sp
[NCBI] 		2831613 Herelleviridae >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK035310 [NCBI]
CDS location
range 27640 -> 29061
strand -
CDS
ATGGAAATTAAAGGTATTGACGTTTCATCGTGGCAAGGGAAACCGGATTGGGCAAAAGTATCAAAATCTGGAGTTAAGTTTGCAATATTAAGAATCCATCAGAAATCTGGAATTGACGAATCATTCGAACACAACTACAAGGGCTGTAAATCCAATGGAATTCTTATTGGTGGATATAAGTACAGCTATGCTTTAACATCGGCACAAGCTATCGATGAAGCTGAGAACGTAATTTCTGTTCTTGGTGGACGTGGACTTGACTTTCCAGTATTCTACGATCTGGAATGGGCACAGCAAAGAAGTCTCGGAAAACAGGCTATCGAGAATATTGCAGTAGCGTTTCTGACCAGAATCAAGAAAGCTGGTTATAAGGCCGGTATCTACTGTAATCTGGACTGGTATAATAACGTTCTGTCAGATGCTTTGAAGCAGTATGATTGTTGGATTGCTCGTTATCCAGCGGATGATAACGGCACTGTCCAAACACGACTGAAGCCATCGGTCGGTGTAGGCTGGCAGTATTCCAGCAAAGGAAAAGTTCCAGGAATCAGCGGAAATGTTGATATGGATGTGTTCTACAAGGACTACAGAGATTCTAACCAGAAAGGAGAAACTAAAATGGTAAAAATCAGTAACTGCGGACATGATGAAAGAGGAAGATATGCAGGTGGGAAAGCAGGAGATCAGACTGGTACAGAATATCAGATCATGAACTGGTACAGCAGACCGTGGCTCTGTGTTCTAAGATTCAATGACGCTAAAATCGCAACCATGATCGCAGACATGGCGACAAAAGCGGCACAGAACAATCTCATCGGATACGATCAGGGCACTGCCGGAAACAGCAATGACCGGTATTCGTTCTGGCGGCACTTAAAGGCAAGTAACTACGATCCGGCGCAGATCACAATAGCTTGTGAATCTGACTGTAGTGCAAGTACAGCTGCAATCGTTAAGGGTGCTGGATATCGCCTAAATAATGCAAAACTGAAAGCAGTAAGCATCTATCTGACAACGCGAAACATGAGACAGGCATTGAAGAATGCAGGGGCAAAGGTACTGACGGATAGAAAGTATCTGACATCCGGTGACTATCTAAAGGCAGGAGATATCCTCCTGAATGATAACCACCACGTGGCTATCGCTGTTACCACTGGCGCAAAAGCAAGTACGCTTTCAACGCCAACTATCCTGTCTAAAACTCCGAAGTGGGTGGGTAAGGTAACTGCAAATAAACTCAATGTTCGCACATGGGCAGGAACTGAGAACCCACAGCTCAAAAGCTATCCCGTACTTGCAAAAGGAAATCTTGTTGATGTGTGTGATACGATCAAAGCAAAAGATAAAACCGACTGGTATTACATCAGAATTGCCGGAAAGTACTTTGGATTTGCTTCCGCGAAATATATTTGCAAAGTGTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (8pZP5) rather than this protein.
PDB ID
8pZP5
Method AlphaFoldv2
Resolution 84.60
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50