Protein

Protein accession
A0A8S5VE68 [UniProt]
Representative
3TFvI
Source
UniProt (cluster: phalp2_34333)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MNGIDISKWQAGIDLSKVPCDFVIVKASGGLGYPNFDFDRQIKQAMSLGKLVGVYHFARDGYTGTTPEQEAEVFLKKVKPFIGKAILVLDWEADAVKLGAGWAKRWLDYVRKETGVTPFL
Physico‐chemical
properties
protein length:120 AA
molecular weight:13339,3 Da
isoelectric point:8,66
hydropathy:-0,06
Representative Protein Details
Accession
3TFvI
Protein name
3TFvI
Sequence length
509 AA
Molecular weight
56419,64560 Da
Isoelectric point
4,49729
Sequence
MLRGIDISGHQSGIDVSAIDCDFVIVKATGGDGFVNPDFRRQADQVLSSGKMLGLYHYARDHGYEGDAYGEAIHFLSHVADYVGKALMCLDWEADALDLPIGWAQSWMDTVAAETGCNTWFYSGASFVNSADCRPIANRPLWMASYLYRYEGVYGFVDDPDLTWGSGSFPCVKCYQYSSTTHLGGYGGTLDVNVFYGDRAEFASYYGGAPGGSGYVEYTHRVEDMCNYAVAYAADDSHGYTQDMQGRWGQDRDCATFIWDSAHIAGFDVGWGPDETRYTGTIIPVFEQAGWTAVEYDGNPKRGYVLWKPGHVELHLGDGMNAGAHCSETGDAYGEPGDQTGDEISVTPNPGGWTIMLIPPAEIPMLKEDDLKPVINEGGEVRRLYHPDGGGDHLYTTSKAEIEKLVNEEHWADEGVMFTAPCPGRYPVFRMLNPNSIDHFWTVDYSECERLQAAGWRYEGVPFFVNQEGGEVYRLFNPNAGDHLWTMGTEERDGLVSQGWVYEGVAWRV
Other Proteins in cluster: phalp2_34333
Total (incl. this protein): 9 Avg length: 449,3 Avg pI: 5,11
Protein ID Length (AA) pI
3TFvI 509 4,49729
3TNJB 454 4,36281
3VIuM 487 4,87965
40mwz 477 4,43193
4Od5a 491 4,71470
4k4ws 491 4,49184
4kiw6 508 5,60787
8n81C 507 4,33326
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_37225
24mkV
 7 36,5% 383 4.599E-100
2 phalp2_4039
19nTK
 10 32,2% 573 1.817E-81
3 phalp2_13609
5otWQ
 1 31,1% 379 2.059E-69
4 phalp2_24501
4L4WX
 2 28,7% 518 7.826E-60
5 phalp2_6342
7hreA
 7 31,4% 382 6.396E-57
6 phalp2_30164
3yWnL
 3 28,5% 406 2.338E-53
7 phalp2_32938
3TLgl
 6 23,4% 413 3.416E-26

Domains

Domains [InterPro]
GH25
Unannotated
DUF5648
Representative sequence (used for alignment): 3TFvI (509 AA)
Member sequence: A0A8S5VE68 (120 AA)
1 509 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF18885

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctClL93
[NCBI] 		2825381 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK016246 [NCBI]
CDS location
range 25529 -> >25887
strand +
CDS
ATGAACGGCATTGATATTTCCAAATGGCAGGCGGGCATTGACCTGTCGAAAGTTCCCTGCGATTTTGTGATCGTCAAAGCTTCCGGCGGTCTCGGCTATCCGAACTTCGACTTTGACCGGCAAATCAAACAGGCAATGTCTCTCGGCAAGCTTGTGGGCGTTTACCATTTCGCCCGCGACGGTTATACCGGGACGACGCCGGAACAGGAGGCCGAAGTATTCCTGAAGAAAGTAAAGCCCTTCATCGGAAAGGCTATCCTCGTGCTTGACTGGGAGGCCGACGCTGTGAAGCTGGGCGCGGGATGGGCAAAGCGCTGGTTGGATTATGTCCGTAAAGAAACCGGCGTGACGCCCTTCCT

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (3TFvI) rather than this protein.
PDB ID
3TFvI
Method AlphaFoldv2
Resolution 83.79
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50