Protein

Protein accession
A0A8S5U9N3 [UniProt]
Representative
3gW4A
Source
UniProt (cluster: phalp2_37519)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 97% (predicted by ML model)
Protein sequence
MAKQLCIDVSEHNGTIDWAAVKKAGINYAIIRDGYGTSHVDNCFVRNMEGAIAHGVHIGIYHFSYALSAAGAKAEAEYVLKLIQPYKDKIVLPVFFDFEYDTVDYAKKQGVTLGKEAFNAHTVAFCDTIQAAGYRAGVYYNLDYLHRYVDIDRIGKYVQWYAQYSSTASATTWDLWQYSSSYTITGCAGKFDVSVLKNSGSVTNSRKYKLGWNKDDKGWWYADTESTYYKSRWAKINDKWYSFDKEGYMLSNTWQVEAGGDTYYLGAEGDMQTNMVVGLGADGKLQPIEPWYHTLGEVPQGYRKELDKLVDAGKLKGKSGSGDDMVLDMPLSALRVLIILSR
Physico‐chemical
properties
protein length:342 AA
molecular weight:38453,9 Da
isoelectric point:6,25
hydropathy:-0,35
Representative Protein Details
Accession
3gW4A
Protein name
3gW4A
Sequence length
385 AA
Molecular weight
44401,57940 Da
Isoelectric point
9,63617
Sequence
MTVTYRQYDARWGNIVYTKGGSTLAHAGCGDTSVAMLATNNPKYANVTPKDVVPFMKKHGYNYKGTTWDGITKGLEHYGFVTARSSNAETIFKWLDGGFFDRGIINFEAGKQGGVTWTSGGHYVVFSAYEKRGNKHWFYTRDPGMRKNDGWHCFEKTMSELIRMIFVCYLPSEHRKPEVIQPKKKTNIKCIDVSEAQGKIDWKKVKADGIKYAIIRAGYGWTHVDKCFKQNIKGAHEAGLKIGIYWFGYAYKKEHAIAEAEGCLRTILPYRKWIDLPVFYDWEYDSMKYAKKHGVKPNKSLITTFNKLFCSRVKAAGFKVGVYYNLDYKKNYLNLKKLDGFYKWLAYYTKTKQKNIAVQQYTNKGKVNGINGRVDRDWIVNEKLL
Other Proteins in cluster: phalp2_37519
Total (incl. this protein): 4 Avg length: 389,8 Avg pI: 7,97
Protein ID Length (AA) pI
3gW4A 385 9,63617
3iwKw 489 9,66164
A0A8S5NDY4 343 6,32637
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_819
41pAM
 11 28,3% 536 3.909E-112
2 phalp2_10790
3TNSu
 2 28,0% 406 7.695E-46
3 phalp2_24349
3WAOt
 2 23,3% 424 3.886E-33

Domains

Domains [InterPro]
PET_C39
GH25
Representative sequence (used for alignment): 3gW4A (385 AA)
Member sequence: A0A8S5U9N3 (342 AA)
1 385 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF13529

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctKNZ79
[NCBI] 		2825440 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK016045 [NCBI]
CDS location
range 10470 -> 11498
strand -
CDS
ATGGCTAAACAGCTGTGTATTGACGTGTCCGAGCACAACGGCACAATCGACTGGGCCGCAGTCAAAAAGGCTGGGATTAACTATGCCATTATCCGGGACGGCTACGGAACGAGCCACGTTGACAACTGCTTTGTGCGCAATATGGAGGGCGCGATTGCCCATGGTGTCCATATTGGTATCTACCATTTTTCTTACGCTCTGAGCGCCGCCGGAGCCAAAGCGGAAGCAGAATACGTCCTCAAACTGATCCAGCCGTACAAGGACAAGATCGTATTGCCGGTATTTTTTGATTTTGAGTATGATACCGTGGACTACGCAAAAAAGCAGGGCGTGACCCTGGGCAAGGAGGCGTTCAACGCCCACACCGTGGCGTTTTGCGATACCATTCAGGCGGCGGGGTACCGGGCTGGTGTCTACTACAACCTGGACTATCTGCACCGTTACGTGGACATTGACCGGATCGGCAAATACGTGCAGTGGTACGCCCAGTATTCGTCCACCGCTTCGGCGACCACCTGGGATTTGTGGCAGTACTCCAGCAGCTACACGATTACAGGTTGCGCCGGTAAGTTTGATGTCAGCGTGCTTAAAAACTCCGGCAGCGTCACCAACAGCCGGAAGTACAAGCTGGGATGGAACAAGGATGATAAGGGCTGGTGGTATGCGGACACAGAATCCACCTATTACAAGTCCAGATGGGCAAAGATCAACGACAAGTGGTACAGCTTTGACAAGGAGGGCTATATGTTGAGCAATACGTGGCAGGTAGAGGCCGGGGGTGACACCTACTATCTCGGCGCGGAAGGAGATATGCAGACCAATATGGTTGTAGGCCTTGGCGCAGACGGGAAACTCCAGCCCATTGAGCCGTGGTATCACACTCTGGGCGAGGTGCCGCAGGGATACCGCAAGGAGCTGGACAAGCTGGTGGACGCCGGGAAGCTCAAGGGCAAGAGTGGAAGCGGAGATGATATGGTGCTGGATATGCCGCTGAGCGCACTGAGGGTGCTGATTATCCTGAGCCGATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (3gW4A) rather than this protein.
PDB ID
3gW4A
Method AlphaFoldv2
Resolution 93.10
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50