Protein

Protein accession
A0A8S5TRH0 [UniProt]
Representative
6cDEC
Source
UniProt (cluster: phalp2_17569)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MAISPLATEKYAAHPSNYTAGRPQGAPDHITVHHMAGVLSAAQCGAVFQRPGRGGSAHYGIGNGGEIANYVDENDTAWSDSNWNSNCKTISIETANSENGGEWPVGEAAFNSLVKLVADIAKRNGLGHLVPGVNLCWHSMYAQTTCPGNHLRGRMHELAERANAINEAASAPAPAPQPNKSNETIADEVIRGDWGNGEDRKARLAAAGYDYAAVQAIVNQKLAPQPAPEPAPEPFKVGDTVVPTRLVDYNGTPLVQYDPTYTIAELNGNRAVLTARGAVWAAMRTEDIRRA
Physico‐chemical
properties
protein length:291 AA
molecular weight:30970,1 Da
isoelectric point:5,84
hydropathy:-0,43
Representative Protein Details
Accession
6cDEC
Protein name
6cDEC
Sequence length
148 AA
Molecular weight
16063,07640 Da
Isoelectric point
9,27927
Sequence
MGNSNLVSVKVPAHSNNYTVGRSGRRIEYIAIHHMAGILTAAQCGNIFKNGSRKASSNYGIGKDAEVGLYVDEANTSYCNSNWDSNCKSVTIEVSNCALGGDYPVSDPVLNKLIQLVADIAKRNNLGKLIKGKNVVWHRMYTATTCPR
Other Proteins in cluster: phalp2_17569
Total (incl. this protein): 34 Avg length: 173,6 Avg pI: 8,27
Protein ID Length (AA) pI
6cDEC 148 9,27927
1kXLT 174 8,17171
2maMF 149 9,34574
366MA 130 7,79927
3TCRe 158 7,59326
3TJpQ 154 9,09754
3ZNxm 206 8,58411
3ZXNg 209 6,64632
3gIpW 136 5,31254
3p3Co 217 8,48341
40j4l 185 8,51951
40n7v 120 6,70822
4JZSY 154 6,92347
4k52i 165 8,79544
5RVId 169 9,75402
5T4cK 142 8,85327
5Ta2l 235 8,62634
5Wcg4 156 8,75237
5ZCA7 163 9,54082
60S1M 164 9,15485
64X78 140 8,71911
67xaJ 165 9,01966
68ROk 177 5,83290
6YR32 190 4,71459
6eZIr 128 7,51618
6hLlP 196 8,27253
758DJ 159 9,82816
7WjVy 112 8,50585
7s1Hv 269 9,79824
8d8DB 211 9,18857
8lzSr 213 9,18373
8vtkl 151 9,33549
odKL 166 9,33478
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_12971
3esnk
 626 37,9% 158 1.683E-57
2 phalp2_27777
7pibA
 19 39,2% 158 5.623E-53
3 phalp2_19897
5WUZ5
 55 45,9% 124 1.649E-50
4 phalp2_26785
3pb5n
 118 38,7% 160 1.649E-50
5 phalp2_1359
1dk8I
 5 39,1% 161 1.876E-48
6 phalp2_7262
3WyJ7
 1 30,8% 149 1.033E-45
7 phalp2_27000
8m8EW
 1 32,9% 158 2.589E-38
8 phalp2_539
wKIS
 2 35,2% 105 3.020E-33
9 phalp2_14312
3Q436
 4 39,1% 97 4.247E-30
10 phalp2_6357
7sHfT
 17 24,5% 155 4.415E-24

Domains

Domains [InterPro]
Ami2
Representative sequence (used for alignment): 6cDEC (148 AA)
Member sequence: A0A8S5TRH0 (291 AA)
1 148 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ct1SN28
[NCBI] 		2825308 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015910 [NCBI]
CDS location
range 12540 -> 13415
strand -
CDS
ATGGCTATTTCACCACTTGCAACTGAGAAATACGCAGCACACCCAAGCAACTACACCGCAGGCAGGCCACAGGGCGCCCCAGACCACATCACGGTCCACCACATGGCCGGAGTGCTATCTGCAGCACAATGCGGCGCTGTGTTCCAAAGACCAGGGCGAGGCGGAAGCGCGCACTACGGTATTGGCAATGGCGGGGAAATCGCTAACTACGTGGATGAGAACGATACGGCATGGAGCGACAGCAACTGGAATAGCAACTGCAAGACAATCAGCATCGAAACCGCAAACAGCGAAAATGGCGGAGAGTGGCCAGTTGGAGAGGCTGCCTTTAATTCGCTTGTGAAGCTCGTAGCAGACATCGCGAAGCGCAACGGACTCGGACACCTAGTGCCGGGCGTGAACCTCTGCTGGCACAGCATGTACGCCCAGACGACCTGCCCAGGCAACCATCTCCGCGGCAGAATGCATGAACTAGCCGAAAGAGCCAACGCAATCAACGAAGCAGCCTCTGCACCAGCACCAGCCCCACAGCCAAACAAGAGCAACGAAACGATTGCAGATGAGGTAATCCGTGGTGATTGGGGGAACGGAGAAGACCGCAAAGCCCGTCTCGCGGCAGCAGGCTACGACTATGCAGCCGTTCAAGCAATCGTAAACCAGAAACTAGCACCACAGCCAGCCCCAGAACCAGCACCGGAGCCTTTCAAAGTAGGAGACACAGTAGTGCCAACGAGGCTCGTAGACTACAACGGCACCCCACTCGTGCAGTACGACCCGACCTACACAATTGCCGAGCTAAACGGCAACCGCGCCGTACTCACAGCCAGAGGCGCAGTATGGGCAGCAATGCGAACTGAGGACATTCGTAGGGCTTAG

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0009254 peptidoglycan turnover biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0071555 cell wall organization biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.5.1.28 None Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00001561

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (6cDEC) rather than this protein.
PDB ID
6cDEC
Method AlphaFoldv2
Resolution 96.86
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50