Protein

Protein accession
A0A8S5SYZ4 [UniProt]
Representative
41dSE
Source
UniProt (cluster: phalp2_40067)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MLRGVDVSENNGIVDWGRVALGLDFAIIRIGYGRNHLDSQFYNNINGALTAGLKIGIYHYGYALLPERAQEEARFVVETLADCGLSPEKLEMGIWFDMEDADGYKQRHGMPSRQEITAMCSEFICECNRSGYSCGIYASLDWLEHQIATEQLASYVPYWVAQWGGRCDWPNASMWQYTDGYYVDGKEFDGNLYFD
Physico‐chemical
properties
protein length:195 AA
molecular weight:22209,6 Da
isoelectric point:4,54
hydropathy:-0,32
Representative Protein Details
Accession
41dSE
Protein name
41dSE
Sequence length
516 AA
Molecular weight
58139,79670 Da
Isoelectric point
4,87141
Sequence
MSISKIINIALAEVGYVEKASNSSLYDKKANPGSANWTKYGAWYGLNGPGAPWCDMLVSWCAEQAGEASAVGRFSYVPYHAKFFQERGQYFARGEKLPQAGDVIFFREFEHIGLVEYCDGTYVYTIEGNTSDGDTLDPNGGAVCRKCYSLDSVYIQGYGRPDYQEDDEKEEEATTVSTKVLGIDVSEHNGTINWTAVKQAGVEFAIIRTGYGKSYVDSQFKRNITQAIAQGIHVGVYHFTYALDAAGVKREAEFVLSLLKDYKIDLPVFFDFEYDTVRYAKENGVTLGRQAFLDHTKAFCDVIEAAGYRAGTYYNYSYYKQYYDKNTLGSYVQWYAQYNATADISGWDIWQYSSKGTLSGCTGHFDMNEMTRETFEKLTNFKMAGWQKDSNGWWYRYEDGSYPKAALAGIDGCWYYFDDDGYLVQNASWSYNGVLYTADNDGKVTFEEENAVKEEKYYEKLGDLPAHYRTEIDKLVAAGFLRGKSGEGDSMVLDLHEEAVRSLVVLARVAAQNGLI
Other Proteins in cluster: phalp2_40067
Total (incl. this protein): 5 Avg length: 339,8 Avg pI: 4,75
Protein ID Length (AA) pI
41dSE 516 4,87141
19dgZ 559 5,34482
A0A8S5NFR7 198 4,05003
A0A8S5SLF2 231 4,92063
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_18637
9X15
 5 33,8% 357 2.431E-54
2 phalp2_30281
4kq4k
 1 34,1% 369 4.699E-51
3 phalp2_31158
4080K
 37 28,7% 348 2.552E-42
4 phalp2_820
41q9o
 8 30,6% 330 4.633E-42
5 phalp2_3439
3WDPn
 5 32,8% 347 2.379E-39
6 phalp2_1872
3VMqM
 12 28,0% 484 1.046E-38
7 phalp2_35722
3WziM
 1 26,2% 374 1.941E-31
8 phalp2_26596
8k4xQ
 4 25,9% 332 3.646E-27

Domains

Domains [InterPro]
CHAP
GH25
Unannotated
Unannotated
Representative sequence (used for alignment): 41dSE (516 AA)
Member sequence: A0A8S5SYZ4 (195 AA)
1 516 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF05257

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ct8wU2
[NCBI] 		2827791 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK032699 [NCBI]
CDS location
range 253 -> 840
strand -
CDS
ATGTTAAGAGGTGTTGACGTAAGCGAAAATAATGGTATAGTTGATTGGGGGAGGGTAGCCCTTGGCTTAGATTTCGCTATTATCAGAATCGGTTATGGTCGGAATCATTTGGATAGCCAATTTTACAACAATATCAATGGCGCATTAACTGCAGGCTTGAAAATTGGTATTTATCACTACGGTTACGCATTATTACCGGAAAGAGCACAGGAGGAGGCAAGGTTCGTCGTTGAGACGCTAGCAGATTGTGGATTAAGTCCCGAAAAGCTGGAAATGGGTATATGGTTTGACATGGAAGATGCAGACGGATATAAACAGCGTCACGGTATGCCTTCACGTCAGGAGATTACCGCAATGTGCAGTGAATTTATCTGTGAGTGTAATCGCAGTGGCTATAGTTGTGGCATATATGCTAGCCTGGATTGGTTAGAGCATCAGATTGCCACAGAGCAACTTGCTAGTTATGTGCCATATTGGGTAGCTCAGTGGGGCGGGCGCTGCGACTGGCCGAATGCTAGTATGTGGCAGTACACTGATGGGTACTATGTTGATGGCAAAGAGTTTGATGGGAATCTTTATTTTGACTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (41dSE) rather than this protein.
PDB ID
41dSE
Method AlphaFoldv2
Resolution 89.85
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50