Protein

Protein accession
A0A8S5SKJ4 [UniProt]
Representative
5VYYI
Source
UniProt (cluster: phalp2_16399)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MRILAVVVAVLLACTPAIAMADMVGIDVSGWQASNVTCTAQYDFAVVKVSQGVGFENGSWRTQARCVTDRGKSLGLYHYAGGNNAEAEADYFVGRARDYIGRAVLVLDWESYQNAQWGNSDWVRRFVQRVHTLTGVWPMVYVQASALGQIPGDVRANCGLWVAQYASNAPTGYQSRPWNYAVYGEAMRQYTSNGWISGYNGPLDLNYFRGDASQWQAYANPAGAAKPATPPQTEKPPTQTIDLQALATATIRGDYGNGQQRRDALGANYDKVMAIVNQRLAGTATVAPQQAAQANTTRVAVRSGDTMSGIASRTGLWPLSKWSVPSGNLNLIYPGQVVTYNGGGSVATGSNAPPATRTVTVRSGDTLSGIAARLGIGYTQLTGYRSGNPNVIYPGEVLHY
Physico‐chemical
properties
protein length:400 AA
molecular weight:42912,5 Da
isoelectric point:9,15
hydropathy:-0,22
Representative Protein Details
Accession
5VYYI
Protein name
5VYYI
Sequence length
544 AA
Molecular weight
59218,15670 Da
Isoelectric point
9,59066
Sequence
MGKIKNKSKPLQALIAALFAVLLACTPAIAMADMVGIDVSGWQDANVTCTASYDFAVVKVSQGVGFENSSWRTQAKCVTDRGKSLGLYHYAGGNNAEAEADYFVGRARDYIGRAVLVLDWESYQNAQWGNSDWVRRFVQRVHTLTGVWPMVYVQASALGQIPGDVRANCGLWVAQYASNAPTGYQSRPWNYAIYGEAMRQYTSNGWISGYNGPLDLNYFRGDASQWQAYANPAGAAKPVTPPPTEKPPTQTIDLQALATATIRGDYGNGQQRRDALGANYDKVMAIVNQRLGSATVATQQTTQANTTRVTVRSGDTMSGIASRTGLWPLSRWSVPSGNLNLIYPGQVVTYNGGGSVATGSNAPPSRTVTVRADPRPRMGLDVGRSGRDDHQRRRPDHRRRHRRKHPQGQGIQGRITRSPRTYRTHGMVRGLFVVYVSGVDDLAASHGAQPVGDPCVDDGVAADRQIGGFLVQFADHPRGHRQRDPLLQRGMMLDHGIVEIDVVEDVVAVVEHLLKLVAGDRLGVNLILGCHSMPPRSCVIGARI
Other Proteins in cluster: phalp2_16399
Total (incl. this protein): 86 Avg length: 411,6 Avg pI: 9,42
Protein ID Length (AA) pI
5VYYI 544 9,59066
1mU34 410 9,28469
1nvgm 411 9,46140
3B3rD 408 9,57434
3GQ3V 408 9,53044
3LhJu 411 9,47719
3jGrX 411 9,56274
3pRai 411 9,28527
3qHJe 411 9,28456
3qQ7z 410 9,28437
3qtWD 411 9,34787
3sneF 411 9,56280
3tWt0 410 9,28456
3tZXA 410 9,52857
3uJS8 411 9,34787
3vt3N 404 9,20043
3wzOb 410 9,36095
4VtpA 411 9,44631
4z9nq 410 9,44612
5Kj4Z 408 9,62392
5LJnq 410 9,44612
5Lsv7 408 9,53070
5MRKk 411 9,54617
5Mac0 410 9,44612
5Nndi 411 9,49357
5RPwu 411 9,44631
5SbiV 410 9,49763
5Shuz 411 9,51536
5TCiw 410 9,27199
5UKGu 410 9,27179
5UoRV 410 9,28456
5VC5e 410 9,44721
5VdVB 410 9,60658
5Wl5R 411 9,59749
5X88R 410 9,25967
5Zcny 410 9,48164
5ZiOg 408 9,53006
62cGg 411 9,48190
63odu 411 9,46140
640xz 408 9,59040
64ztD 410 9,28469
66Bju 410 9,28456
68C08 409 9,28437
69hfU 412 9,31125
69kxP 411 9,38990
6aPIF 408 9,59040
6eRR2 412 9,28540
6eaga 408 9,46707
6fNmC 411 9,51065
6gWXM 411 9,52838
6gZqM 410 9,28456
6gs9E 410 9,27179
6h3NU 411 9,51065
6hSVe 408 9,54385
6la84 410 9,48164
6mSpn 411 9,38926
6noZb 410 9,27212
6pKOv 409 9,25948
6pN09 412 9,36115
6pkmA 410 9,37494
6sulL 410 9,60684
6sx1B 409 9,28456
6uPnj 410 9,27179
720du 411 9,46140
720hE 411 9,29752
7BeZu 410 9,36115
7BqIQ 411 9,52857
7C2EJ 410 9,37475
7C2FH 410 9,37475
7WZZy 410 9,28456
7da6a 411 9,49743
7dtie 412 9,41259
7ptH6 410 9,42523
7tYYG 411 9,43155
7tZ6S 410 9,56293
7ueg8 411 9,53070
7ueiG 410 9,42781
7ueno 410 9,42781
7uu89 410 9,46140
7uufD 410 9,55900
7vp0b 411 9,46140
7xn6R 411 9,56255
7xn7N 411 9,49357
8fKAs 410 9,36115
8tNgf 411 9,43155
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_9153
6wSxJ
 7 28,1% 352 7.255E-17
2 phalp2_17042
7nSW4
 41 27,0% 351 4.529E-14

Domains

Domains [InterPro]
Unannotated
Unannotated
Unannotated
Disordered region
Representative sequence (used for alignment): 5VYYI (544 AA)
Member sequence: A0A8S5SKJ4 (400 AA)
1 544 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctZgu8
[NCBI] 		2827893 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK032617 [NCBI]
CDS location
range 33047 -> 34249
strand +
CDS
ATGCGGATCCTCGCGGTCGTCGTCGCCGTGCTGCTCGCGTGCACGCCGGCGATCGCGATGGCCGACATGGTCGGCATCGACGTGTCCGGCTGGCAGGCCTCGAACGTGACCTGCACCGCGCAGTACGACTTCGCCGTCGTCAAGGTCAGCCAGGGCGTCGGCTTCGAGAACGGGAGCTGGCGCACGCAGGCCAGGTGCGTGACGGACCGGGGCAAGAGCCTCGGCCTGTACCATTACGCCGGCGGCAACAACGCCGAGGCCGAGGCCGACTACTTCGTCGGCCGGGCGAGGGACTACATCGGCAGGGCCGTGCTCGTGCTCGACTGGGAGTCCTATCAGAACGCCCAGTGGGGCAATTCCGACTGGGTTCGCCGGTTCGTCCAGCGCGTCCACACGCTCACCGGCGTATGGCCGATGGTGTACGTGCAGGCCAGCGCGCTGGGCCAGATACCCGGCGACGTGCGCGCCAACTGCGGCCTGTGGGTCGCCCAGTACGCCAGCAACGCGCCCACCGGCTACCAGAGCCGACCGTGGAACTACGCGGTCTACGGCGAGGCCATGCGCCAGTACACCTCCAACGGCTGGATCAGCGGCTACAACGGGCCGCTCGACCTCAACTACTTCAGAGGCGACGCAAGCCAGTGGCAGGCCTACGCCAACCCCGCCGGCGCAGCCAAGCCCGCAACCCCGCCGCAGACCGAGAAGCCGCCGACCCAGACCATCGACCTACAGGCCCTCGCCACCGCCACCATCCGTGGCGACTACGGCAACGGCCAGCAGCGGCGCGACGCGCTCGGCGCGAACTACGACAAGGTCATGGCGATCGTCAACCAGCGCCTCGCCGGCACCGCGACCGTAGCGCCGCAGCAGGCCGCGCAGGCCAACACGACCCGCGTGGCCGTCCGCTCCGGCGACACCATGAGCGGCATCGCCTCGCGCACCGGCCTGTGGCCGCTGTCCAAGTGGAGCGTGCCCAGCGGCAACCTCAACCTGATCTACCCCGGTCAGGTCGTCACCTACAACGGCGGCGGCAGCGTCGCCACCGGCAGCAACGCGCCGCCGGCAACCCGTACCGTGACCGTGCGCAGCGGCGACACCCTCAGCGGCATCGCCGCCCGCCTCGGCATCGGCTACACGCAGCTCACCGGCTATCGCAGCGGCAACCCCAACGTGATCTACCCCGGCGAAGTGCTGCACTACTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (5VYYI) rather than this protein.
PDB ID
5VYYI
Method AlphaFoldv2
Resolution 62.60
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50