Protein

Protein accession
A0A8S5SDZ1 [UniProt]
Representative
3TLHo
Source
UniProt (cluster: phalp2_16055)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MGKIADISKHQGRVDWEQAATELDLAILRASYGVQSVDERYHENVEGCLKYGVPFGAYHYVYAGNALKARQEARSFVKTARAEAKEPAFWIADIEYKTQDKKTTDAVCAAFLDELRRQGCKKIGLYINTRYPYLRQETINECDIMWIPHWGPNDGNVPGDSAKPQYPHDIWQYTSYGALAGVEGRVDLNMLTGTKPLEYFTGAQEEPEKPAEDEEKAVLYLVTLGAYTSREKAQEAAEKARTLGLNAEVMDVYGDHEDAENAIEAVEIAPSTWNVRKGPGTQYGIIGVAREGEVYEKDEEASTEDWVCILYCGTQGYISAKGVVDK
Physico‐chemical
properties
protein length:326 AA
molecular weight:36418,2 Da
isoelectric point:4,85
hydropathy:-0,55
Representative Protein Details
Accession
3TLHo
Protein name
3TLHo
Sequence length
274 AA
Molecular weight
30942,54380 Da
Isoelectric point
5,46901
Sequence
VSRHDKTIDWDKARKELDFVIIRSSVGLKTDPQFVRNALLCGIPFGVYHYVEAGTAEAAEKEAEYFYHAARGFSDEKTVYAKNKKPAMVAKEGDISPLFWAVDIEADAQTRETTETVTRAFLEKLRSFGVRKIGLYANTRRKYMSDELVASFDWTWVPRYGPDDGEAHPDEFPPKYPCDIWQYTTVGAIDGIDHDVDLNMLYGEKPLEYFTMRSAVKITGGSVNVREFAGTSSKIVGVAHAGDILERVGLDGWVPVVWNGRMCWVSWKHAESVD
Other Proteins in cluster: phalp2_16055
Total (incl. this protein): 2 Avg length: 300,0 Avg pI: 5,16
Protein ID Length (AA) pI
3TLHo 274 5,46901
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_12693
24JaA
 16 49,7% 213 6.261E-67
2 phalp2_19522
3xyel
 1 40,4% 183 2.004E-51
3 phalp2_32637
21xEV
 86 35,4% 220 3.062E-44
4 phalp2_2120
3gPQA
 3 37,0% 216 9.811E-36
5 phalp2_24235
2VKgf
 225 31,4% 216 3.145E-30
6 phalp2_32227
7cHL2
 31 35,2% 221 9.318E-29
7 phalp2_13529
7Jyqc
 660 32,7% 211 1.906E-21
8 phalp2_15044
7hFHn
 33 29,3% 215 1.597E-20
9 phalp2_39103
2m4j4
 107 29,5% 227 3.966E-20
10 phalp2_3425
3TK4D
 923 31,2% 221 5.369E-20

Domains

Domains [InterPro]
GH25
SH3_3
Representative sequence (used for alignment): 3TLHo (274 AA)
Member sequence: A0A8S5SDZ1 (326 AA)
1 274 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF08239

Taxonomy

  Name Taxonomy ID Lineage
Phage Caudovirales sp. ctrNG92
[NCBI] 		2827638 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK032578 [NCBI]
CDS location
range 38967 -> 39947
strand +
CDS
ATGGGCAAGATTGCGGACATCAGCAAGCACCAGGGCAGAGTGGACTGGGAGCAGGCGGCGACGGAGCTTGATCTGGCGATACTGCGCGCGTCCTACGGCGTGCAGAGCGTGGACGAGCGGTATCACGAGAACGTGGAGGGATGCCTGAAATACGGCGTGCCCTTCGGCGCATACCACTACGTGTACGCGGGCAACGCGCTGAAGGCGAGGCAGGAGGCGCGGTCGTTTGTGAAAACCGCGCGGGCCGAGGCGAAGGAACCGGCCTTTTGGATTGCGGACATCGAGTACAAAACGCAGGACAAAAAAACGACCGACGCGGTGTGCGCGGCCTTCCTTGACGAGCTGAGGAGGCAGGGGTGCAAGAAGATCGGCCTGTACATCAACACGAGGTATCCGTACCTGAGGCAGGAGACGATCAACGAGTGCGACATCATGTGGATACCGCACTGGGGCCCAAACGACGGAAACGTGCCGGGCGATTCGGCGAAGCCGCAGTACCCGCACGACATCTGGCAGTACACCAGCTACGGGGCGCTCGCGGGCGTGGAGGGACGAGTTGACCTGAACATGCTGACCGGCACGAAGCCGCTTGAATACTTTACGGGCGCGCAGGAAGAGCCTGAAAAGCCCGCTGAGGACGAGGAAAAGGCGGTGCTGTACCTGGTGACCCTGGGCGCATACACGAGCAGGGAGAAGGCGCAGGAAGCCGCTGAAAAGGCGCGCACACTCGGCCTGAACGCGGAGGTCATGGACGTGTACGGAGACCATGAGGACGCAGAGAACGCGATTGAGGCGGTGGAGATTGCGCCCTCGACCTGGAACGTGCGAAAAGGCCCGGGCACGCAGTACGGCATTATCGGCGTGGCGCGTGAGGGCGAGGTGTACGAGAAGGACGAGGAAGCGAGCACGGAGGACTGGGTGTGCATACTGTACTGCGGCACGCAGGGCTACATCAGCGCGAAGGGAGTTGTGGACAAATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (3TLHo) rather than this protein.
PDB ID
3TLHo
Method AlphaFoldv2
Resolution 90.45
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50