Protein

Protein accession
A0A8S5S7S1 [UniProt]
Representative
67VKs
Source
UniProt (cluster: phalp2_30592)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 97% (predicted by ML model)
Protein sequence
MEIKGIDVSSNQGKPDWTKVAKSGIKFAILRVHQKAGIDGSFEYNYKGCKSNGILIGGYKYSYALTPAQAIDEAEDVIAALNGRGLDFPVFYDLEWSNQRKLGKQAIENIAVAFLTRMKKAGYKVGIYCNLDWYNNVLTDALRKYDCWIARYPANDNGSVQERLRPTVGVGWQYSSKGKVSGISGNVDMDVFYKDYKEEVSTMDKAIEKVILIAKNEIGYLEKKSNSQLDSKTANAGSNNHTKYWRDIKPSYQGQPWCACFVSWCFMKAFGLETARKLLKHWPYVYCPTMSGLFTLNANPKVGDIVIFKHNGTFTHTGLVTAVVGDRFYTIEGNTSGASGIIANGGGVCAKSYLNSQMPGTKFCTPDWKLVKGTSTNTSNTGGKKYMFTTETVVAGSTGLSVLLLQEILVARKFKGKDGKELELDRSAGANTIYALNAYKKSRNMKQDGICDAAVWKDLIAL
Physico‐chemical
properties
protein length:462 AA
molecular weight:51061,8 Da
isoelectric point:9,21
hydropathy:-0,31
Representative Protein Details
Accession
67VKs
Protein name
67VKs
Sequence length
349 AA
Molecular weight
39199,83000 Da
Isoelectric point
9,00032
Sequence
MFHEIMKELIELEIKGIDVSSFQGKPDWSKVSNSGVKFAILRIHQKSGVDTSFEHNYKGCKSNGILIGGYKYSYALTPAQAIDEAEDVLSVLGGRGLDFPVFYDLEWSQQRSLGKQAIENVAIAFLTRIKKAGYKVGIYCNLDWYNNVLTDALKKYDCWIARYPASDNGSVQERLRPNVGVGWQYSSKGKVSGISGNVDMDVFYTDYRTEQKGEVTVAKTKLQKFTELGDYYASNGGYLEKKSNAYLDDFKKNAGYNNYTKFARDVNSWGQPGCQAQPWCAEYQFWKLVKVLGITKALKIMGGGFYNCQSITRHAKANGTWHSTPKDGALVIFRDGSHIGSVRSYSNTY
Other Proteins in cluster: phalp2_30592
Total (incl. this protein): 21 Avg length: 449,6 Avg pI: 9,20
Protein ID Length (AA) pI
67VKs 349 9,00032
2m4EF 367 9,10418
3pFuR 480 9,32214
3pI62 477 9,48035
3pLYh 478 9,50536
3pzvH 473 8,80975
3qNig 329 9,03655
4VMfs 478 9,47236
5K5zA 474 9,38094
5P6Wk 477 9,30558
5T8Vi 482 9,41279
5TWhH 490 9,14569
5XKX9 364 9,21216
60TZf 488 8,93720
6mXV2 250 8,94436
6mmEH 544 8,81600
6rl7Y 486 9,00528
7wHUT 474 9,37501
7wHVN 547 9,33684
8eUTX 473 9,39918
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_16417
6gC98
 231 85,5% 339 4.355E-207
2 phalp2_40154
8pZP5
 3 83,1% 225 2.020E-123
3 phalp2_38736
13rhz
 58 36,7% 376 1.324E-67
4 phalp2_26548
858CP
 728 47,4% 217 2.372E-59
5 phalp2_12020
7Olig
 697 41,8% 258 4.420E-59
6 phalp2_4916
6k3vw
 208 34,7% 365 7.402E-51
7 phalp2_34377
4dm6y
 15 32,2% 366 4.746E-50
8 phalp2_24035
8aWkT
 56 38,3% 253 4.142E-49
9 phalp2_13529
7Jyqc
 660 34,3% 253 1.794E-37
10 phalp2_4009
11iJK
 7 31,4% 356 2.436E-37

Domains

Domains [InterPro]
GH25
Unannotated
Representative sequence (used for alignment): 67VKs (349 AA)
Member sequence: A0A8S5S7S1 (462 AA)
1 349 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctVDy27
[NCBI] 		2827881 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK032543 [NCBI]
CDS location
range 18205 -> 19593
strand +
CDS
TTGGAAATTAAAGGAATCGACGTATCATCCAACCAAGGAAAACCGGACTGGACGAAAGTAGCTAAATCCGGTATTAAATTTGCGATTTTGAGAGTGCATCAGAAAGCCGGTATTGACGGCTCATTCGAGTATAACTACAAGGGATGCAAGAGCAACGGAATCCTTATCGGCGGGTACAAGTATTCATACGCCCTGACACCGGCACAGGCTATTGACGAAGCGGAGGATGTAATTGCCGCGCTGAACGGACGTGGACTGGACTTCCCAGTGTTCTATGATCTCGAGTGGTCTAATCAGCGAAAGCTCGGTAAACAGGCTATCGAAAATATTGCCGTAGCATTTCTGACTAGAATGAAAAAAGCCGGTTATAAGGTCGGTATCTACTGCAATCTGGATTGGTACAACAATGTTCTGACTGATGCACTTAGGAAGTACGACTGTTGGATTGCTCGTTATCCTGCTAACGACAATGGTTCTGTACAAGAAAGATTACGTCCGACAGTCGGTGTAGGTTGGCAGTATTCCAGTAAAGGAAAAGTATCCGGTATCAGCGGAAATGTTGATATGGATGTGTTCTATAAGGATTATAAAGAGGAGGTTTCTACAATGGACAAAGCTATCGAAAAAGTGATCCTCATTGCAAAAAATGAAATCGGGTATCTTGAAAAGAAAAGCAACAGCCAGCTCGACAGCAAGACTGCAAATGCAGGCTCAAACAATCACACAAAATACTGGAGAGATATTAAGCCATCTTATCAGGGGCAGCCTTGGTGCGCTTGTTTCGTGAGCTGGTGCTTTATGAAAGCGTTCGGACTTGAAACGGCTAGGAAACTGCTGAAACACTGGCCTTATGTGTATTGTCCGACCATGAGCGGATTGTTTACGCTTAATGCTAATCCAAAAGTTGGTGATATCGTGATATTTAAGCACAATGGTACATTTACTCATACCGGATTAGTCACGGCGGTTGTTGGCGATCGTTTTTATACCATTGAGGGTAATACTTCCGGTGCATCTGGTATTATCGCAAACGGCGGTGGTGTTTGTGCAAAAAGCTATCTTAACAGTCAGATGCCGGGAACGAAATTCTGCACACCGGACTGGAAGCTCGTAAAAGGAACGTCAACTAATACATCAAATACAGGAGGAAAGAAATATATGTTCACAACAGAAACAGTAGTAGCAGGCAGCACAGGACTTTCTGTCCTTCTTTTACAGGAGATTCTTGTAGCACGAAAATTCAAAGGAAAAGACGGTAAAGAGCTTGAACTTGATCGTTCTGCCGGAGCAAACACCATCTATGCTCTGAATGCTTATAAAAAATCCAGAAATATGAAACAGGACGGAATCTGTGATGCAGCAGTCTGGAAAGATTTGATTGCACTTTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (67VKs) rather than this protein.
PDB ID
67VKs
Method AlphaFoldv2
Resolution 90.81
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50