Protein

Protein accession
A0A8S5RYS8 [UniProt]
Representative
1Hwxo
Source
UniProt (cluster: phalp2_10365)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MMKVIDISAWQEWIDWQAVKDAGIEGVILKIGEHYKLDEKFIEHVNNAVAYGLRYGIYYYAHASTIDEAIAEANWVDKQI
Physico‐chemical
properties
protein length:80 AA
molecular weight:9259,4 Da
isoelectric point:4,79
hydropathy:-0,11
Representative Protein Details
Accession
1Hwxo
Protein name
1Hwxo
Sequence length
602 AA
Molecular weight
65290,71660 Da
Isoelectric point
9,57312
Sequence
MAFTRNQMVELALRYKGATTGSAKHKDLVNTFNKVRPHGEVGNYRCPWCAITVTAWFLKGGWTQSNMAMSYNCGTLISDAKKLGIWVENDAYIPKIGDVIIYYWGDSGKGDATSGASHVGMVISVGNKEFTVLEGNKGSGVCGTRLMAVNARYIRGFITPRYSGDESLKTTYKPSTPFTGSLPSKNVGYGTNGSDTKKVQKFLNWAINAKLTVDGECGAKTVLAIQIFEATYNVPNADGIFGAGCRNAANELIAKFATTKTATTTKETTTETKVVTSTGLTVDGVGGKATVKAMQKFFGSTVDGVISGQKKSLSKYYPAVQSVTFDGNGSACVAKMQKWLGINADGIWGKGTSVALQKKLGVEADGVFGKNSMKALQKYLNAQTSSTETKKTSTSTSATTTPTTTTKKSVYNVIDVSSWQGKIDWKKVKAAGIDGAIIRYADGTTLDSCFDQNMKGAIAAGLHVGCYIYSRAKTKAKARTEAERLYKAVKQYKYDMPMYIDLEASAIAKYANTVAVAFITKIDSLGGWAGIYANLNWYNNYLVKTLSKYSARPLWIAQYNNKITHKTPSLFGIWQYTSSGSVNGINGRVDRDKCYVAYWDKK
Other Proteins in cluster: phalp2_10365
Total (incl. this protein): 3 Avg length: 389,3 Avg pI: 7,88
Protein ID Length (AA) pI
1Hwxo 602 9,57312
3h0BB 486 9,26889
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_1872
3VMqM
 12 29,7% 621 7.890E-46
2 phalp2_31158
4080K
 37 23,9% 605 1.920E-35
3 phalp2_16855
1Jgdv
 1 23,7% 615 5.853E-31

Domains

Domains [InterPro]
Unannotated
Unannotated
Unannotated
GH25
Representative sequence (used for alignment): 1Hwxo (602 AA)
Member sequence: A0A8S5RYS8 (80 AA)
1 602 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctWdm1
[NCBI] 		2827883 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK032509 [NCBI]
CDS location
range 65198 -> >65437
strand +
CDS
ATGATGAAAGTAATTGATATTTCTGCTTGGCAAGAATGGATCGATTGGCAGGCAGTAAAAGACGCTGGAATTGAAGGAGTTATTCTAAAAATAGGAGAACATTATAAACTTGATGAAAAGTTTATAGAACATGTAAATAACGCTGTAGCGTATGGATTACGCTATGGCATATATTATTATGCTCATGCTTCAACAATTGATGAAGCTATAGCAGAAGCTAATTGGGTAGATAAACAAATC

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (1Hwxo) rather than this protein.
PDB ID
1Hwxo
Method AlphaFoldv2
Resolution 86.21
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50