Protein

Protein accession
A0A8S5RX59 [UniProt]
Representative
69Der
Source
UniProt (cluster: phalp2_3807)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 96% (predicted by ML model)
Protein sequence
MEIKGIDVSSNQGKPDWAKVAKSGIKFAILRVHHRTGIDNSFEYNYKECKSNGILVGGYKYSYALTPAQAIDEAEDVIAALNGRGLDFPVFYDLEWSNQRKLDKQAVENIAVAFLTRMKKAGYKVGIYCNLDWYKNCFSNALKQYECWIANYPKKELDNGTLQERLRVPVGVGWQYSEHGKVSGISGNVDMDVFYKNYKEEVSVMNKAIKKVILIAKNEIGYLEKKSNSQLDSKTANSGSANYTKYWRDVKPSYQGQPWCACFVSWCFMKAFGLEKAKKLLKHWPYVYCPTMSGLFTLNANPKVGDIVIFKHNGTFTHTGLVTAVVGDRFYTIEGNTSGASGIIANGGGVCAKSYLKSQMPGTKFCTPDWKIVNGTSTNISTTGGKYMFTTETVVAGSTGLSVLLLQEILAARKFKGKDGKELDLDRSAGTNTIYALNAYKKSRNMKQDGICDAAVWKDLIAL
Physico‐chemical
properties
protein length:463 AA
molecular weight:51467,4 Da
isoelectric point:9,20
hydropathy:-0,31
Representative Protein Details
Accession
69Der
Protein name
69Der
Sequence length
279 AA
Molecular weight
30965,67950 Da
Isoelectric point
5,67534
Sequence
MTAIEKVIRVAENEVGYLEKASNSQLDSKTANAGTANYTKYWRDIKPDYQGQPWCACFVTWCFVNAFGVSNALKLLKHYPYVYCPTMASLFTLNSNPKVGDIVIFKHNGEFTHTGIVTVVDGDYFETVEGNTSGGSTIIANGGGVCKKSYYNSNLPGTKFCTPEWSIVSNESEGLTVTQYEELKDLITKQGTIIAQLKAENAVLKEENVKIMNVLESTFVFDYVDENMPDWAKPAVLAAVKSGAIQGKDESGRLGLSYKDLRQIVREYRQGIYDKPSVH
Other Proteins in cluster: phalp2_3807
Total (incl. this protein): 57 Avg length: 277,7 Avg pI: 5,98
Protein ID Length (AA) pI
69Der 279 5,67534
135VM 267 6,34325
1nu77 266 5,32214
1qSM9 231 6,58351
1qU69 258 5,49721
2mcVY 276 6,51622
2mcmn 277 5,45782
2meqa 277 5,31771
2mxFd 266 5,67108
3A3rq 258 5,47521
3dnHQ 262 5,37358
3jL8R 248 5,45799
3lSja 261 5,53171
3lf31 266 5,29003
3liwE 266 5,95186
3m9PD 266 5,29003
3mxfy 262 5,37358
3pD9f 262 5,24854
3pIY5 280 5,99944
3plKz 261 5,08620
3qWoG 262 5,25536
3r7Dr 266 5,69330
3sG63 266 5,46089
3tbzT 261 5,78424
3uUy8 262 5,14799
3uy8a 262 5,37358
3wzlg 262 5,37358
3x6Q8 266 5,68529
4VBwY 277 5,49459
4ydw9 269 4,83640
4yfzj 239 6,93819
4ylnU 261 5,16129
4ym9n 263 5,10888
5NjMY 266 5,46822
5YIjZ 266 5,15714
6Yeh9 262 5,24854
6cWKk 277 5,49465
6fXET 277 5,50755
6n2Mm 277 5,10769
6oe53 277 5,49459
6pej7 266 5,30969
6qbYd 269 5,34994
6rUp1 266 5,96135
6sr3Z 288 8,02124
6w3zc 266 5,95578
7WGuS 288 6,83906
7XjPF 265 8,34300
7Xq1i 264 6,81706
8k0qs 273 6,89272
8qV4r 262 5,26405
8sI3n 262 5,37358
8tPJC 222 8,61048
Ow08 262 5,37358
ojqV 259 8,32753
A0A8S5T3N0 574 9,28404
A0A8S5V2R4 475 8,87822
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_4499
3nCxR
 65 35,5% 253 4.107E-45
2 phalp2_27350
4yaBH
 91 40,7% 184 5.392E-35
3 phalp2_30889
EYMp
 8 38,9% 195 1.918E-32
4 phalp2_21394
409Ja
 1 32,4% 268 2.666E-30
5 phalp2_34753
3g9I4
 5 37,7% 196 1.243E-29
6 phalp2_16018
3yVVm
 206 26,4% 280 2.547E-22
7 phalp2_1568
7XJtL
 188 36,1% 180 8.097E-20
8 phalp2_14320
3VFlX
 143 30,8% 185 6.703E-19
9 phalp2_11549
ZJ7o
 17 30,5% 206 1.656E-18
10 phalp2_22287
7C3Cm
 23 29,3% 184 7.270E-15

Domains

Domains [InterPro]
CHAP
Unannotated
Unannotated
Representative sequence (used for alignment): 69Der (279 AA)
Member sequence: A0A8S5RX59 (463 AA)
1 279 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF05257

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctEJG5
[NCBI] 		2827814 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK032506 [NCBI]
CDS location
range 39949 -> 41340
strand +
CDS
GTGGAAATTAAAGGAATTGACGTATCATCTAATCAGGGGAAACCGGACTGGGCGAAGGTTGCTAAATCCGGTATTAAATTCGCAATCTTGAGGGTACACCACAGAACCGGCATTGACAACTCATTCGAGTACAACTACAAGGAATGCAAGAGCAACGGAATCCTTGTCGGCGGATATAAGTATTCATACGCCCTGACACCGGCACAGGCTATTGACGAGGCGGAAGATGTGATTGCTGCACTGAACGGACGAGGACTGGATTTTCCGGTGTTCTACGACCTTGAGTGGTCTAATCAGCGGAAACTCGACAAGCAGGCAGTCGAAAACATTGCAGTCGCATTTCTGACAAGGATGAAAAAAGCTGGTTATAAGGTCGGTATCTACTGCAATCTGGACTGGTATAAGAACTGCTTTTCAAACGCTCTGAAGCAGTACGAATGTTGGATTGCGAACTATCCCAAAAAAGAACTGGATAACGGAACATTACAGGAAAGGCTGAGAGTTCCGGTCGGTGTAGGATGGCAGTATTCGGAACACGGAAAAGTATCCGGTATCAGCGGCAACGTGGACATGGATGTATTCTATAAAAATTATAAAGAGGAGGTTTCTGTAATGAACAAAGCTATTAAAAAAGTGATTCTCATTGCTAAAAACGAAATTGGGTATCTCGAGAAGAAAAGTAACAGCCAGCTCGACAGCAAGACTGCAAATTCGGGAAGTGCGAACTACACAAAATACTGGCGTGATGTGAAACCATCTTATCAGGGGCAGCCCTGGTGCGCTTGTTTCGTGAGCTGGTGCTTCATGAAAGCGTTCGGGCTTGAGAAAGCCAAGAAACTCTTGAAGCACTGGCCTTATGTGTACTGTCCGACTATGAGCGGCTTATTTACGCTTAACGCTAACCCGAAGGTTGGCGATATCGTGATATTTAAGCACAATGGCACATTTACCCACACCGGATTAGTCACGGCGGTTGTTGGCGACCGTTTTTATACCATCGAGGGCAATACTTCCGGTGCATCCGGTATTATCGCAAACGGCGGCGGTGTTTGTGCAAAAAGCTATCTTAAAAGTCAGATGCCGGGAACAAAATTCTGCACACCGGACTGGAAGATCGTAAATGGAACATCAACTAACATATCAACGACAGGAGGGAAATATATGTTCACAACAGAAACAGTAGTAGCAGGCAGCACAGGACTTTCTGTTCTTCTTTTACAGGAGATTCTTGCAGCACGAAAATTCAAAGGGAAAGACGGTAAAGAGCTTGATCTTGATCGTTCTGCCGGAACAAACACCATCTATGCTCTGAATGCTTACAAGAAATCCAGAAATATGAAACAGGACGGAATCTGCGATGCGGCTGTCTGGAAAGATTTGATTGCACTTTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (69Der) rather than this protein.
PDB ID
69Der
Method AlphaFoldv2
Resolution 91.23
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50