Protein

Protein accession
A0A8S5RWS3 [UniProt]
Representative
N6at
Source
UniProt (cluster: phalp2_35522)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MSLTGIDVSSYQGTINWWAVKQNGIDFAILKVIRKDLNPDKKFEENWKGCQEHNVHVHGVYEYGYITTVAKSRSDARRVLTILNGRKVTVYLDVEDAVMKGLGKNIIPIINAYGKVITDAGLPFGVYTGESFYKTYIKPYGGVSYPMWIARYGKNNGKCDVKYQPQVPNMVGWQYTSKGRVGGIVGNVDMNVWYKELDTVYEDSTSHSNPYTEPERLLYYKPLARMKGNDVKWVQYELVRKGFMPSVNAKGKTNIDGDFGKTTSDAVKAFQKSVGIKVDGKVGAVTRAYLKK
Physico‐chemical
properties
protein length:292 AA
molecular weight:32877,3 Da
isoelectric point:9,45
hydropathy:-0,44
Representative Protein Details
Accession
N6at
Protein name
N6at
Sequence length
179 AA
Molecular weight
20194,96090 Da
Isoelectric point
9,54978
Sequence
GKVITDAGLPFGVYTGESFYKTYIKPYGCVSYPMWIARYGKNNGKCDVKYQPQVPNMVGWQYTSKGRVGGIVGNVDMNVWYKELDAVYEDSTSHRNPYTEPERLLYYKRLAMMKGNDVKWVQYELVRKGFMPSVNAKGKTNIDGYFGKTTSDAVKAFQKSVGITVDGKVGAVTRAYLKK
Other Proteins in cluster: phalp2_35522
Total (incl. this protein): 2 Avg length: 235,5 Avg pI: 9,50
Protein ID Length (AA) pI
N6at 179 9,54978
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_8612
21tAg
 1 29,9% 167 3.567E-11
2 phalp2_22565
1zIZR
 1 28,4% 151 4.163E-05

Domains

Domains [InterPro]
GH25
PG_1
Representative sequence (used for alignment): N6at (179 AA)
Member sequence: A0A8S5RWS3 (292 AA)
1 179 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF01471

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctLeh52
[NCBI] 		2827849 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK032499 [NCBI]
CDS location
range 18671 -> 19549
strand +
CDS
ATGAGTTTAACAGGAATTGATGTGTCCTCATACCAGGGGACAATTAACTGGTGGGCGGTAAAGCAGAACGGCATTGATTTTGCTATTCTGAAAGTTATCCGTAAGGATCTGAACCCGGACAAAAAGTTTGAGGAGAACTGGAAAGGTTGCCAAGAGCACAATGTCCATGTGCACGGAGTATATGAATACGGATATATTACAACGGTTGCAAAATCACGCTCTGATGCAAGAAGAGTGCTTACTATCCTTAATGGCAGAAAAGTTACGGTATACCTTGATGTTGAAGATGCCGTGATGAAAGGTCTTGGTAAAAATATTATTCCTATTATCAATGCTTATGGCAAAGTCATCACCGATGCAGGATTGCCATTCGGTGTATATACTGGGGAAAGTTTTTACAAGACTTACATTAAGCCTTATGGTGGTGTAAGTTATCCTATGTGGATTGCACGGTACGGCAAGAATAACGGAAAGTGTGATGTGAAGTATCAACCGCAAGTACCTAACATGGTAGGCTGGCAGTACACCTCTAAAGGGCGTGTAGGCGGCATTGTAGGCAATGTGGACATGAATGTATGGTACAAGGAGTTAGACACTGTATATGAGGATTCTACAAGCCATAGCAACCCTTATACAGAGCCGGAAAGACTTCTGTATTACAAACCACTGGCAAGAATGAAGGGAAATGATGTCAAGTGGGTTCAGTATGAACTTGTAAGAAAAGGATTTATGCCGTCTGTAAATGCGAAAGGAAAAACAAACATTGATGGAGATTTCGGAAAAACTACTTCTGATGCAGTAAAAGCATTCCAAAAGAGTGTGGGAATCAAAGTGGATGGAAAAGTCGGTGCGGTTACAAGGGCATATCTCAAAAAGTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (N6at) rather than this protein.
PDB ID
N6at
Method AlphaFoldv2
Resolution 88.81
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50