Protein

Protein accession
A0A8S5RRS8 [UniProt]
Representative
1nEC9
Source
UniProt (cluster: phalp2_23836)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 96% (predicted by ML model)
Protein sequence
MNNKVVFYDPNLAAQFIELYEGYRSNAYKCSAGVYTIGIGHTKGVKQGDKITRQKAYELFSQDLINTHNDLINLVKVPINEKQFIALMSFVYNFGMSKCRTYSIFDDINRGDFITAARKFTDYRSPGSTSEKGLTKRRLAEQRLFVSNMNLDP
Physico‐chemical
properties
protein length:153 AA
molecular weight:17517,8 Da
isoelectric point:9,32
hydropathy:-0,42
Representative Protein Details
Accession
1nEC9
Protein name
1nEC9
Sequence length
355 AA
Molecular weight
38514,25790 Da
Isoelectric point
5,83818
Sequence
MTINQEGLELIKKSEGLRLETYLDSRGIPTIGYGHTAGVLVGDKISQDQADAFLHLDLAGAEADVARLVKVPLSSNQFSALVSFVYNVGSGQFKASTLLAKLNAGDFQGAAEQFPQWIHAGDHIDPGLVIRRAAEQRLFLKETAPVFDPKASSVWRLFAPPERWQVALTVTDEQRKALSWAATQLGLIYREDAQACKAFLGLQRSGPVAIKVVPQSQHTPDSCGQTSVAMAIDALMAKSLTDSDINSRYGYELLTALNQECAPKFAWEDKDFQTTDWPRLESQTAKGLPAVIGLNGPAFSPDGRGHIVLIAAVNGTQVTFADPARGSFRTCTKADIETAPPHPDGKFLFIPRVQI
Other Proteins in cluster: phalp2_23836
Total (incl. this protein): 6 Avg length: 288,3 Avg pI: 8,04
Protein ID Length (AA) pI
1nEC9 355 5,83818
4gPfp 354 9,14673
8aILz 355 8,65483
8iX0m 357 8,44712
A0A1S6L191 156 6,82190
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_31943
7FwYi
 314 30,8% 370 1.275E-55

Domains

Domains [InterPro]
GH24
Unannotated
Representative sequence (used for alignment): 1nEC9 (355 AA)
Member sequence: A0A8S5RRS8 (153 AA)
1 355 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Podoviridae sp. ctXdu7
[NCBI] 		2827618 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK057792 [NCBI]
CDS location
range 52431 -> 52892
strand -
CDS
ATGAATAATAAAGTAGTATTTTATGATCCTAATTTAGCAGCTCAATTTATAGAACTTTATGAAGGATATAGATCCAATGCTTATAAATGCTCTGCTGGAGTCTATACAATAGGTATAGGTCATACTAAAGGAGTTAAACAAGGAGATAAAATAACAAGACAAAAAGCTTATGAGCTATTTTCACAAGATTTAATTAATACGCATAATGATTTAATTAATCTTGTTAAAGTACCTATAAATGAAAAACAATTTATAGCTTTAATGTCTTTTGTATATAATTTCGGAATGTCTAAATGTAGAACTTATTCTATATTTGATGATATTAATAGAGGAGATTTTATTACTGCTGCTAGAAAATTTACAGATTATCGTTCTCCTGGATCTACTTCTGAAAAAGGATTAACTAAGAGAAGATTAGCAGAACAACGATTATTTGTATCTAATATGAATTTAGATCCATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (1nEC9) rather than this protein.
PDB ID
1nEC9
Method AlphaFoldv2
Resolution 82.06
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50