Protein

Protein accession
A0A8S5R3F3 [UniProt]
Representative
6lzER
Source
UniProt (cluster: phalp2_39583)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MQFAATYPLAQIQRVQIYNNIKRYRETELDKILQETGGSFVFGGPIFLSDLTACCHLKGDGVVYGAPDYQVWGMAWGQDAQDYAMRRLPCETDNYVECVALIVDGDPLAAPHYQPDMGGRRPRQAIGTKEGRFAYLVTQTPYTPEELRDVLVAAGWNSAVMLDGGGSVCYRDRAGNGFVCDADRVIPYYLVVHLADDVSEPDTTGGQYVVTAQSGLNIRKGPGTSFDKLGGYSYGAVVAVQAVRDGWGQTDRGWVSMDYLRPVEAAEEGLVTDTGLRVLQDILPAEADNRPGGSNPDTYITIHETGNFARGADAAAHAAYLRGSSAQEALVSWHYTVDDHSIYQHLPDGERAYHAGDGGSGSGNATSIGIEICVDSGGNFEQAKSNAASLVRLLMAKHGIQLGHVVQHNHWNGKDCPKTIRATAGAWEAFLALCGGQGFPQDTDQELKAAVDALAAAGIIDSPERWMALDFTANSVRLLLIKMGRYVTH
Physico‐chemical
properties
protein length:489 AA
molecular weight:52858,5 Da
isoelectric point:5,06
hydropathy:-0,25
Representative Protein Details
Accession
6lzER
Protein name
6lzER
Sequence length
485 AA
Molecular weight
51389,07730 Da
Isoelectric point
7,08927
Sequence
MSKYVSAIPLEQIVRAELVEAKGRSMSQVKTAVGCDQIINCWFYNMSTGRPVGNLKINGVVKANAGWSGYGLTWDAGADMRLALVPVQGGENYLSGVELLTPSRQEGAKLSYDAAYGGRRGRSAAMIAGETLVLYCSGDGTGDAKTPEALRDELAAIGRKYEPSGTLYATGWDSGGSSQCDFGGGRKITSSRKVAGYFCLWLEKDEQKGDRPVGRQYKVTPSVGVNIRSGPGTGYSKVGAYACGTVVAVTAAQGGWGQTAKGWVALEYLAAVEGAQRTTDTGMKIRTAYIDAGRKNRPGGVNPCRYITIHETGNKASGADAEAHGAYLNSSAGEADLVSWHYTVDDHAIVQHLPDGETAYHAGDGKAGTGNAQSIGIEICVNADGNFAKAKANAAALVRLLMEEHGIPIANVVQHNRWNGKDCPYAIRHTAGAWEAFLALCGGESAVETDRKAVQERFGLADETMDYLEAYKYGKDLLAKLASGK
Other Proteins in cluster: phalp2_39583
Total (incl. this protein): 145 Avg length: 484,5 Avg pI: 5,60
Protein ID Length (AA) pI
6lzER 485 7,08927
13qBZ 464 8,52686
13riu 496 6,64450
13sbN 499 5,09319
13tKw 466 6,39816
1m2rv 474 5,02107
1mUi3 484 5,63157
1mWMn 493 5,24700
1maaz 499 4,98946
1mnCY 499 5,20880
1nPBO 499 4,93711
1nSI8 498 5,16225
1nceG 461 5,00185
1ncme 485 5,63157
1o632 506 5,06108
1oiEh 506 5,06108
2m0BS 513 5,40069
2mBZV 488 4,86476
2mfBS 488 4,88391
2sZP 364 4,81190
3B71V 499 5,15754
3GC2W 487 4,95809
3dnM7 498 5,06085
3jMEI 498 5,08865
3jMGZ 443 5,29270
3jUP0 499 5,05511
3kaMJ 498 5,94754
3kzQw 488 5,13958
3oVPN 433 4,92916
3pNbi 497 5,34044
3pUWH 498 5,02220
3q2jT 497 5,10019
3qAi1 483 5,63157
3qvdU 499 5,21511
3qvja 484 5,79283
3rWb2 483 6,12721
3s0xc 488 4,95212
3sAAK 488 5,67670
3sInB 499 5,12065
3sMaF 498 6,89010
3sRN9 484 5,63157
3sV5W 490 5,24586
3t1K7 490 5,19454
3uG2m 489 5,42582
3uG8o 498 5,03954
3uzme 498 5,07057
3uzzm 499 6,28789
3vSJ1 494 6,02268
3vVDz 506 5,06108
3w0Ol 484 5,63157
3wAXq 488 4,98247
3wBk8 488 5,02198
3wjem 366 5,34942
3wqE6 494 5,45281
3wuoy 399 4,83594
3xKFc 498 5,25933
3yLSl 483 5,12730
3yNGm 493 5,44196
4tfXj 488 5,20835
5Qcuu 484 6,32211
5U8nk 498 5,21392
5VjPb 471 6,02791
64cDG 473 6,63916
65BVp 499 5,10149
65uJ6 488 5,38142
67B27 498 4,97417
69S0t 498 5,20392
6YmdA 484 5,29202
6d8Z1 472 6,02410
6dLzy 490 6,07691
6fnLt 484 6,32211
6iD5W 476 5,07421
6iLqD 490 5,39757
6ievD 490 5,45270
6jBpT 483 5,82801
6jTIe 474 5,06745
6kriZ 489 5,01390
6lb1j 464 6,85981
6lnfw 359 6,01848
6mt5s 498 5,26951
6pE6x 473 6,85958
6pM0D 499 5,17015
6pRgz 474 4,89863
6tsOx 486 6,07867
6vu35 494 5,23330
6wsVX 494 5,44531
721Li 425 5,86188
722EI 487 5,31845
7QI9T 424 5,86188
7XSE4 498 5,10110
7YX2i 484 5,61390
7YfeZ 499 5,09422
7YnkZ 488 4,90654
7b705 517 5,41399
7lwKf 498 5,04511
7ornj 489 7,19084
7pF40 484 5,60730
7piag 482 4,99270
7r1xg 499 6,76545
7r2Dr 493 6,27579
7r2JV 498 5,12559
7r2q7 498 5,14202
7vCPO 493 8,02504
7vUGh 483 4,96332
7vUHR 480 5,01652
7xEjZ 498 5,86768
7xEpX 497 7,57444
7xEpn 491 5,91043
7xEq0 491 5,72854
7xVDe 424 5,23774
7xVhT 483 5,71217
84MxM 495 8,81001
86eCi 487 7,96760
86led 488 5,41814
86s49 467 6,36877
879t1 499 5,08865
8IjxH 413 5,76486
8bQ9A 489 6,60767
8eoCL 484 5,63157
8fMXl 506 5,06460
8gjB2 490 5,37165
8jN7Q 490 5,13850
8kUKD 488 4,87124
8lFsi 484 5,75417
8oObf 499 5,15202
8omox 490 5,13440
8ou2O 488 4,68935
8ow0P 498 5,12849
8pGAb 485 6,52588
8payE 487 5,14532
8qm1h 488 4,96411
8r48R 507 4,93382
8rGiW 487 7,14366
8rkKd 497 5,25757
8tG8X 490 5,19454
8tMRJ 498 5,16322
8vPP2 490 5,82988
8vR21 506 5,06563
CZgx 506 5,16561
Ofiv 472 5,55262
mXqq 487 7,57496
nJlp 487 7,56160
ntc3 487 7,57496
z3MV 490 5,38574
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_33286
5VpKY
 6 56,0% 341 6.528E-173
2 phalp2_37124
1kg2x
 6 24,6% 483 2.869E-33

Domains

Domains [InterPro]
Unannotated
SH3_3
Ami2
Unannotated
Disordered region
Representative sequence (used for alignment): 6lzER (485 AA)
Member sequence: A0A8S5R3F3 (489 AA)
1 485 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510, PF08239

Taxonomy

  Name Taxonomy ID Lineage
Phage Myoviridae sp. ctxi06
[NCBI] 		2826713 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015798 [NCBI]
CDS location
range 4438 -> 5907
strand -
CDS
ATGCAGTTTGCGGCAACCTACCCGCTGGCGCAGATCCAGCGGGTGCAGATCTACAACAACATCAAGCGGTACCGGGAGACGGAGTTGGACAAAATCCTGCAGGAGACCGGCGGCAGCTTTGTCTTCGGCGGGCCGATCTTTCTGAGCGATCTGACGGCCTGCTGCCACCTGAAGGGAGACGGCGTGGTGTACGGCGCGCCGGACTACCAGGTGTGGGGCATGGCCTGGGGACAGGATGCCCAGGACTACGCCATGCGGCGGCTACCCTGCGAGACGGACAACTATGTGGAGTGCGTGGCGCTGATCGTGGACGGCGACCCGCTGGCAGCGCCCCACTACCAGCCGGACATGGGCGGCAGACGGCCCCGCCAGGCCATCGGCACCAAGGAGGGGCGGTTTGCCTATCTTGTCACCCAGACGCCCTACACCCCGGAGGAACTGCGGGACGTGCTGGTGGCCGCCGGCTGGAACAGCGCGGTGATGCTGGACGGCGGCGGGTCCGTGTGCTACCGGGACCGGGCGGGCAATGGCTTTGTTTGTGACGCAGACCGGGTGATCCCCTACTATCTCGTGGTCCACTTGGCGGACGATGTGTCCGAACCTGACACCACCGGCGGGCAGTATGTGGTGACGGCCCAAAGCGGCCTTAATATCCGCAAGGGGCCGGGCACATCCTTTGACAAGCTGGGAGGCTATTCCTACGGCGCCGTGGTGGCCGTCCAGGCCGTCCGGGACGGCTGGGGGCAGACGGACCGGGGCTGGGTGTCCATGGACTACCTGCGGCCCGTGGAGGCCGCAGAGGAGGGTCTGGTGACCGATACGGGGCTGCGGGTCCTCCAGGACATCCTGCCAGCCGAAGCCGACAACCGGCCGGGCGGAAGCAATCCGGACACCTATATCACCATCCATGAGACCGGCAACTTTGCCAGGGGCGCCGACGCGGCGGCCCACGCGGCATACTTGCGGGGCAGCTCCGCCCAGGAGGCTCTCGTGAGCTGGCACTATACCGTGGACGACCACAGCATCTACCAACACCTGCCGGATGGCGAGCGGGCCTACCACGCCGGGGACGGCGGCAGCGGCTCGGGCAATGCCACTTCCATCGGTATCGAGATCTGCGTGGACTCCGGCGGGAATTTTGAGCAGGCCAAATCCAACGCGGCATCGCTGGTGCGGCTGCTGATGGCCAAGCACGGCATCCAACTGGGCCATGTGGTCCAGCACAACCATTGGAACGGCAAGGACTGCCCAAAGACAATTCGGGCCACAGCGGGCGCCTGGGAGGCGTTTCTGGCCCTCTGCGGCGGCCAGGGGTTCCCCCAGGACACGGACCAGGAGTTGAAGGCCGCTGTGGACGCGCTGGCGGCCGCCGGGATTATTGATAGTCCGGAGCGTTGGATGGCGCTGGACTTCACCGCGAACTCGGTCCGGCTGCTGCTGATCAAGATGGGGCGGTATGTGACGCACTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0006508 proteolysis biological process None (UniProt)
GO:0008233 peptidase activity molecular function None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0009254 peptidoglycan turnover biological process None (UniProt)
GO:0030420 establishment of competence for transformation biological process None (UniProt)
GO:0030435 sporulation resulting in formation of a cellular spore biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0071555 cell wall organization biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.5.1.28 None Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00001561

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (6lzER) rather than this protein.
PDB ID
6lzER
Method AlphaFoldv2
Resolution 89.17
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50