Protein

Protein accession
A0A8S5R0Q3 [UniProt]
Representative
6tRKl
Source
UniProt (cluster: phalp2_32115)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 95% (predicted by ML model)
Protein sequence
MKNSAKKFLKLFTLFLIGGLTYCGIEVAWRGYTHWTMAIVGGICFIIVGGLNNYIPWEMAIWKQGIVGALFVTAMEFVVGIPLNLFLGLHIWDYSNLPFNLLGQICLPFTIVWFFLSLLCIFVDDWLRYILFKEEKPKYSMISKQKDETQSAEIEIQSIEQPIAVQAVEQPTKKVADESLKYIVDISYAQGKITDTQWQYFKDNLAGIIIRFGYRGYSKGALKLDKCIEYNIFKCQQYGIPYGLYFFSQAVNKQEGIEEANAVIDSDYFKNAALGIWFDSELGNNGNGRADKISVSARTEAAKGFCDTIIASGKKAGIYASSSWFKTNLNMNELPYPVWVAHYSSDYSYKKNVVLWQYSSTNQLKVPGFNNLDCNKVIDKSFFNGTSVTQNKTKKDHIRAIQSALCVTTDGIAGPKTIAATVTISKDKNYMHPVVKPVQDYLNYLGYDCGNADGIAGAKFGSAVKKFQKDHGCVVDGELTAQKNTWKKLLTV
Physico‐chemical
properties
protein length:492 AA
molecular weight:55270,1 Da
isoelectric point:8,70
hydropathy:-0,05
Representative Protein Details
Accession
6tRKl
Protein name
6tRKl
Sequence length
334 AA
Molecular weight
34762,53190 Da
Isoelectric point
9,39873
Sequence
MATGSQIIENCKKYLGKPYVWGGESMSEGGYDCSGFAYNVLRDSGYKVTRTTAQGFSSLGTAIAYSNAIAGDLLFFGKSKSSINHIAIYAGDGKMYESIGGSSNTKSNPGKGVTLSNVSRRSDLILVKRIAEVTSSSSSTTSSTTRTYLMKGDKGDAVKELQNNLNTLGYSCGSADGIFGDATDKAVRAFQSAYGLTVDGKYGNSSKAKMVEALNAKKSASSTTSSSSTNSNSAFTTFVKSVQSAIGAKVDGVPGSETLSKTITVSKSKNNKHAVVKPLQIYLNALGYDCGNADGIAGSKFDAAVKAYQNANGCVADGEITAGKGTWKKLLKLA
Other Proteins in cluster: phalp2_32115
Total (incl. this protein): 3 Avg length: 369,3 Avg pI: 9,15
Protein ID Length (AA) pI
6tRKl 334 9,39873
13EUu 282 9,35361
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_24049
85WOB
 2 54,6% 216 7.976E-63
2 phalp2_14670
5Yu9b
 118 46,1% 219 2.550E-40

Domains

Domains [InterPro]
NLPC_P60
PG_1
PG_1
Representative sequence (used for alignment): 6tRKl (334 AA)
Member sequence: A0A8S5R0Q3 (492 AA)
1 334 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00877, PF01471

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctyvQ1
[NCBI] 		2826525 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015776 [NCBI]
CDS location
range 55826 -> 57304
strand +
CDS
ATGAAAAATTCTGCAAAAAAATTTCTGAAACTATTTACTTTGTTTTTGATTGGTGGACTAACATATTGCGGAATTGAAGTAGCTTGGCGTGGATATACCCATTGGACAATGGCTATTGTTGGAGGTATTTGCTTTATTATTGTTGGTGGTCTAAATAATTATATCCCTTGGGAAATGGCAATTTGGAAGCAAGGGATTGTTGGGGCGCTATTTGTAACAGCAATGGAATTTGTTGTTGGTATCCCTCTAAACCTATTCCTAGGTCTTCATATTTGGGATTACTCCAATCTTCCATTTAATCTGTTAGGGCAGATTTGTCTACCCTTTACAATTGTCTGGTTCTTCCTCTCTCTTCTTTGTATCTTTGTCGATGATTGGCTAAGATATATTTTATTTAAGGAAGAAAAGCCAAAATATTCTATGATTTCAAAGCAAAAAGACGAGACACAGTCCGCTGAAATTGAAATTCAGTCTATTGAACAACCAATTGCAGTGCAAGCAGTAGAACAGCCCACAAAGAAAGTTGCAGATGAATCTTTGAAGTATATCGTAGATATTTCTTACGCACAGGGTAAGATTACAGACACACAATGGCAATATTTCAAAGATAATTTAGCAGGAATTATTATTCGCTTTGGTTATCGTGGATATTCTAAAGGCGCTCTAAAACTGGACAAGTGTATTGAGTACAATATCTTTAAGTGCCAGCAATATGGTATTCCATACGGTCTGTATTTCTTTTCTCAGGCTGTAAATAAGCAAGAAGGAATTGAAGAAGCAAACGCTGTGATTGACAGTGATTATTTCAAGAATGCTGCGCTTGGAATTTGGTTTGATAGCGAACTAGGTAATAATGGCAATGGCAGAGCCGATAAAATTTCTGTCTCTGCTCGTACAGAAGCGGCTAAAGGCTTCTGCGATACCATTATTGCGTCTGGCAAGAAAGCTGGCATCTATGCTTCTTCTAGTTGGTTTAAGACTAACTTGAATATGAATGAACTTCCTTATCCTGTTTGGGTCGCTCATTATAGTTCTGATTATTCTTATAAAAAGAATGTTGTACTGTGGCAGTATTCTAGCACTAATCAGCTAAAGGTTCCCGGATTTAATAATCTAGATTGCAATAAAGTCATAGATAAAAGTTTCTTTAATGGAACATCCGTAACACAAAACAAAACCAAAAAGGACCATATTAGAGCTATTCAGTCCGCTCTTTGTGTAACTACTGATGGTATCGCTGGGCCAAAAACCATTGCGGCGACGGTCACTATTAGCAAAGATAAAAATTATATGCACCCCGTTGTAAAACCCGTACAGGATTATCTAAATTATCTTGGATATGACTGCGGAAATGCTGATGGTATTGCCGGTGCTAAATTTGGTAGTGCTGTAAAGAAATTCCAAAAAGACCACGGATGTGTAGTTGATGGAGAACTAACAGCACAAAAAAATACTTGGAAAAAACTTTTAACAGTTTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016020 membrane cellular component None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (6tRKl) rather than this protein.
PDB ID
6tRKl
Method AlphaFoldv2
Resolution 85.58
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50