Protein

Protein accession
A0A8S5QUP4 [UniProt]
Representative
2brBA
Source
UniProt (cluster: phalp2_15589)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKIFGIDASKYQGAIDWAKAKAGGVKFAMLKAVSTNNTGLYIDPYFERNYAECKRLGIPVGVYYYTYAQDKAYADKELALLKKAIAGKQFEYPVVVDVEDNNLKPLSKAALTDLVEYAAQTIESWGCYAMVYTYLYYSRVELDMSRLAKHDLWIAHYAAACGYTGAHGMWQYTSTGKVPGVAGNCDCNYAYKDYPAIIKGAGLNGYGKAKPADSVWDSNGPFVIAGATGQDKAALRELCEAKGLTVNKG
Physico‐chemical
properties
protein length:249 AA
molecular weight:27248,8 Da
isoelectric point:8,34
hydropathy:-0,20
Representative Protein Details
Accession
2brBA
Protein name
2brBA
Sequence length
335 AA
Molecular weight
38085,82970 Da
Isoelectric point
4,58363
Sequence
MEFLMADVSRYQGDVDWEKAKADGIQWAMLKTVSTNNREFGGLYVDPFFERNYAECKRLGIPVGVYYYTYAQDKAYADKELALFKQAVNGKTFELPLVVDVEDNLLKPLSADALTDIVIYALETIESWGCYAMLYTYLYYQNTELNMTRLADYDLWLAAYRDNRPTAPKHNIWQFTNEGQIDGFNGNVDLNYAYKNYPEIILGAGLNGFAANGTSALSNEPCKLIIGPMSTGDRVTIGKMLHSLGITYTVTAEGYVITDAEVDYKNKLKIETKCRQITNIVIKDLMDIEIPAECICSACTQLAEYEWKNTELQAENNYLKETLQNIKDMVCETEM
Other Proteins in cluster: phalp2_15589
Total (incl. this protein): 13 Avg length: 269,1 Avg pI: 7,43
Protein ID Length (AA) pI
2brBA 335 4,58363
1Gfh8 258 9,19585
2ooP6 335 4,65303
3o3mw 249 9,03700
5ZgpU 247 7,48981
69i4v 299 9,35431
6koif 253 6,88578
6mvWG 299 9,42504
7pdmh 258 6,51940
7pdnj 258 6,95331
7piS1 209 5,18118
A0A8S5RRH0 249 8,98955
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_3425
3TK4D
 923 39,5% 220 3.508E-69
2 phalp2_26548
858CP
 728 37,3% 238 1.737E-63
3 phalp2_6199
5X5xO
 102 34,0% 261 6.500E-61
4 phalp2_31512
3WNwM
 280 32,3% 263 5.758E-60
5 phalp2_10110
c1k0
 16 34,8% 238 3.985E-57
6 phalp2_27208
3nTXB
 2 35,8% 307 1.221E-55
7 phalp2_529
o3Q8
 73 34,8% 218 5.095E-54
8 phalp2_19012
13yc5
 26 34,6% 248 6.756E-49
9 phalp2_2537
6a7No
 192 37,5% 221 3.181E-48
10 phalp2_15044
7hFHn
 33 33,2% 262 2.781E-47

Domains

Domains [InterPro]
GH25
Unannotated
Representative sequence (used for alignment): 2brBA (335 AA)
Member sequence: A0A8S5QUP4 (249 AA)
1 335 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ct2hZ16
[NCBI] 		2826276 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015739 [NCBI]
CDS location
range 29814 -> 30563
strand +
CDS
ATGAAAATTTTTGGAATTGACGCAAGCAAATATCAGGGCGCCATCGACTGGGCGAAAGCTAAGGCAGGCGGCGTAAAGTTCGCCATGCTGAAAGCCGTGTCCACCAACAACACGGGTCTGTACATTGACCCCTACTTCGAGCGCAACTACGCCGAGTGCAAGCGGCTGGGCATCCCCGTTGGCGTATACTACTACACCTACGCGCAGGACAAAGCCTATGCCGACAAGGAGCTGGCGCTGCTCAAAAAGGCAATTGCGGGCAAACAGTTTGAGTACCCCGTTGTGGTGGATGTCGAAGACAACAATCTCAAGCCCCTGAGCAAGGCGGCGCTGACCGATTTGGTGGAGTACGCCGCGCAGACAATCGAGAGCTGGGGCTGCTATGCGATGGTATACACCTATCTGTATTACAGCCGCGTTGAGCTGGATATGTCCCGCCTTGCCAAGCACGATCTCTGGATTGCCCACTACGCCGCCGCTTGCGGTTACACCGGCGCGCACGGGATGTGGCAGTACACCAGCACCGGCAAGGTGCCGGGCGTTGCGGGCAACTGCGACTGCAACTACGCCTACAAGGATTACCCCGCTATTATTAAGGGCGCGGGTCTTAACGGCTACGGCAAGGCAAAGCCCGCCGACAGCGTGTGGGACAGCAACGGACCGTTTGTCATCGCCGGTGCCACCGGGCAGGACAAGGCGGCACTGCGGGAACTGTGCGAAGCAAAAGGGCTGACTGTCAACAAGGGGTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (2brBA) rather than this protein.
PDB ID
2brBA
Method AlphaFoldv2
Resolution 85.63
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50