Protein

Protein accession
A0A8S5QRJ0 [UniProt]
Representative
1dFr3
Source
UniProt (cluster: phalp2_12562)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 82% (predicted by ML model)
Protein sequence
MDLKNRLKEYEVTKEYQAKLGYFRNGKFWPYSDSLGFSTIGYGHLISKTESFKQGLTELEADQLLSRDLAHAVIQVQSLGLNVPDDWNDFLIIMVFQLGLGSVQKFRKMIAALKVHNYKEAVKQAKDSLWYRQTPNRVNDMIAQLRNK
Physico‐chemical
properties
protein length:148 AA
molecular weight:17161,5 Da
isoelectric point:9,37
hydropathy:-0,44
Representative Protein Details
Accession
1dFr3
Protein name
1dFr3
Sequence length
149 AA
Molecular weight
17368,91940 Da
Isoelectric point
9,44231
Sequence
MSDLKERLKEYEGTLAYQRQRGYYRNGKFFPYKDSLNKLTVGYGHLVLPGENFSTGITEIEADTLLAKDLANVILQVQTLKLNLPPDWNDFIIIMTFQLGFNGIQKFKKMIAALKVKDWKEAINQARYSLWYIQTPNRINSMINELKNK
Other Proteins in cluster: phalp2_12562
Total (incl. this protein): 30 Avg length: 148,5 Avg pI: 8,99
Protein ID Length (AA) pI
1dFr3 149 9,44231
1bJDf 111 5,59906
1bUwb 147 9,40724
1c3Ch 148 9,07974
1c4et 148 8,66818
1daaU 150 9,32131
1jL3F 148 9,46920
3MWaD 148 8,63143
3s1KY 150 9,18695
4EfbK 147 9,32743
4Z6df 147 9,19714
71ECe 150 9,17077
73SDl 150 9,31744
7bj9V 148 8,63143
7dOLm 150 9,23969
7dpnq 150 8,94056
7hV5T 147 9,65867
7k8eO 150 9,39661
7nKy6 150 9,07949
7oPWK 150 9,23969
7og9l 150 9,18695
7p3Gl 148 9,23376
7qI7a 145 9,25439
7s0HM 148 9,08174
7usaJ 150 9,45476
7vLBA 148 9,18702
7w6BL 150 9,13396
7xg19 150 8,90549
8m8vU 180 6,75340
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_27968
RI1z
 5083 38,9% 136 1.560E-29
2 phalp2_21661
31ima
 875 38,8% 144 6.833E-28
3 phalp2_17008
8jNgs
 3526 36,4% 151 3.352E-24
4 phalp2_24486
4I8GZ
 29 30,8% 146 5.682E-23
5 phalp2_2924
QDRo
 8927 33,3% 153 2.737E-22
6 phalp2_24334
3Qw2p
 463 34,7% 138 3.747E-22
7 phalp2_9780
80F6A
 154 35,1% 148 9.621E-22
8 phalp2_32797
2yPO8
 5731 37,9% 116 3.048E-20
9 phalp2_30803
8ATsR
 233 34,6% 150 1.453E-16
10 phalp2_1386
1iVBH
 20 28,0% 121 1.987E-16

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 1dFr3 (149 AA)
Member sequence: A0A8S5QRJ0 (148 AA)
1 149 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Myoviridae sp. ctoNH1
[NCBI] 		2826695 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015718 [NCBI]
CDS location
range 4205 -> 4651
strand +
CDS
ATGGATTTAAAAAACAGATTAAAGGAATATGAAGTTACTAAAGAGTACCAGGCGAAACTGGGTTATTTTAGGAATGGTAAGTTCTGGCCTTACAGTGATTCGTTAGGATTTAGTACAATTGGGTACGGTCATTTGATTAGCAAGACGGAAAGTTTTAAGCAGGGATTGACTGAGTTAGAGGCGGATCAACTACTATCCCGAGATCTTGCACATGCAGTAATACAGGTTCAATCACTGGGGTTAAATGTTCCAGATGACTGGAATGATTTTTTAATCATTATGGTATTTCAGTTGGGATTAGGTAGCGTTCAGAAATTTAGAAAGATGATTGCAGCTTTGAAAGTACATAACTATAAAGAAGCAGTTAAGCAGGCTAAAGACTCATTGTGGTACAGACAAACACCAAACCGTGTAAACGATATGATTGCACAACTGAGAAATAAATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (1dFr3) rather than this protein.
PDB ID
1dFr3
Method AlphaFoldv2
Resolution 95.21
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50