Protein

Protein accession
A0A8S5QAY3 [UniProt]
Representative
3tdUS
Source
UniProt (cluster: phalp2_15741)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 97% (predicted by ML model)
Protein sequence
MEIKGIDVSAYQGKIDWETVADYGMGFAILRITEKGNKTDSTFEQNYKGCTQHGIPVGVYKYSYAKSPAQAEQEAESVLKVLNKRRLNFPVFLDLEWSEQRKLGSAAVEKIALAFLNKTQAAGYQGGIYCNLDWYQNVLTKALKKYDCWIARYPANDNGTLQERLRPEVGVGWQYSSKATIPGIGTKVDRNVFYKNYTEGEGEPMSKIEKAVQQMETWAKDNSHGYDQIYRWGEKGDYDCSAAVIQACQNAGIPVKTGGATYTGNMLKVFTKNGFEVITHEVNLKTGAGLVRGDVLLNTSHHTAMYCGNGKEVEASINEKGTATGGKPGDQTGREFLIRSYRNYPWTHVLRYTKDGTTGNTDTQTGGHYMFEPKTVKKGDNGLSVLLLQEILIARGFKGKDGKPLTLDRAAGTNTIHALTQYQKSRKGVLEADGICGDKTWRDLIAL
Physico‐chemical
properties
protein length:447 AA
molecular weight:49580,4 Da
isoelectric point:8,76
hydropathy:-0,55
Representative Protein Details
Accession
3tdUS
Protein name
3tdUS
Sequence length
604 AA
Molecular weight
67947,53260 Da
Isoelectric point
9,32195
Sequence
MESRQMIIQSVMQVLKSKVDQETLDIVQDALTIELNRYEVQERTTELSVVDNSAVGMLRRYIATKRIEGKAEFTLKRYWEQNLQLICQESEQHHKALIFAQICAGAMPRKDKNMELKGIDVSSWQGKIDWNKVANYGMDFAILRITEAGNVIDGQFENNFAGCNKYKIPVGVYKYSYASTVSEARSEARKVVSVLNGRKIQFPVFLDLENHRQRVLGAESIHNLAEAFREIIVAAGYKFAIYCNLDWYMNVICSHLKKHDFWIARYPANDNGTVVERLRPSWGVGWQYSSKATIPGINTKVDRNIFYKDYTEAKESGTMAKTKEQIIQNVKNDAVSFAVNIANDNSHGYSQRIRSLYEINIPKSFDCSSLALTAYYYAFLKNGLTKQARYLKENCSYTGNMLKMLNAGFEVVARNQTAHKQMIKGDLELADNNPNGSNSHVAMAIGKNDIVHARSSEGTKDTKDNSGNEIRTQPWYLYSHGWTHRLRFTGKGIDFSGLTNTTGSKPTAKPSTSTKPSTTTSKGAGYMFEPKLVKLGSEGTSVLLLQEILIARGFKGKNGKALSLSRKADANTIYALKQYQKSRNGVLSVDGECGKNTWKDLIAI
Other Proteins in cluster: phalp2_15741
Total (incl. this protein): 229 Avg length: 478,7 Avg pI: 8,58
Protein ID Length (AA) pI
3tdUS 604 9,32195
1kdJY 477 8,46884
1mc3O 477 8,66121
1nT25 484 8,21335
1o07v 477 8,46504
1o5v8 477 8,74593
1o8bM 477 8,74593
1r5YK 467 8,42739
21pMx 464 5,15918
24F1t 510 4,79343
2ep6 455 7,78954
2lYOP 491 9,23937
2lt1H 491 9,23318
2mc5T 491 9,25729
2mfK3 477 8,68881
3B2kn 477 8,74593
3B4PA 477 8,57193
3ITxt 477 8,74593
3TCY3 470 8,86203
3TFc7 452 8,76675
3VJtF 455 8,07236
3WBOk 443 8,86971
3WMoy 459 6,03917
3dZEs 545 4,84299
3gauz 470 4,99952
3iBCq 603 5,92122
3jYEt 478 7,59695
3jYsC 477 8,66495
3k1uF 477 8,92921
3k3CQ 477 8,57921
3k4Pz 479 7,50141
3k5Xw 477 8,66495
3kULV 477 8,87448
3kctR 477 8,44241
3kdrw 443 8,57386
3kfBA 477 8,74999
3knYb 477 8,87873
3kriS 485 7,10882
3lHrh 477 8,74199
3ld6P 477 7,45161
3mbYC 477 8,87448
3meYW 604 9,26335
3mv0u 477 8,73793
3ort5 475 8,64935
3p0Ei 477 8,87435
3p24g 477 8,80975
3p3WE 449 8,68023
3p4QV 477 8,80975
3pA5J 477 8,66495
3pDeX 479 8,66141
3pH6N 477 8,55239
3pPDv 477 8,81800
3pifI 477 8,56838
3qAuH 477 8,64200
3qIgO 481 8,93385
3qTqh 398 8,53221
3qcZ8 391 8,54040
3qk4n 477 8,66895
3r7q1 477 8,80975
3r8sc 477 8,66495
3rWh6 477 8,74593
3raKX 477 8,80975
3rukY 477 8,66115
3s4xP 477 8,74199
3s9od 477 8,66495
3sEZm 412 8,62769
3sITz 384 8,48992
3sc4P 491 9,40041
3seyE 334 8,85623
3shGn 427 8,63627
3t7k2 356 8,74857
3tiKF 477 8,87873
3ttkm 397 9,42368
3u1un 477 8,66495
3u60L 479 8,32643
3uDZ6 477 8,57554
3uOgv 477 8,55239
3uZCr 477 7,87586
3ue8a 477 8,74199
3vAyv 485 8,60377
3vrUf 477 8,31012
3w0sh 485 8,52577
3wn1K 486 9,56132
3xyCL 477 8,66876
3yEvh 477 8,44570
3yQw4 477 8,87441
3yrCw 477 8,66495
41g5G 456 8,94449
4VFBy 477 8,87873
4VRDS 411 8,20678
4VuPP 477 8,87873
5JWPJ 508 9,30622
5K0xO 489 6,52724
5KXbh 476 8,72323
5LB4q 473 9,17909
5MjS4 447 8,66844
5Mkb9 475 9,22467
5NT9p 485 7,46685
5NcDQ 508 9,26573
5OWYo 485 6,84139
5PO5Q 473 9,18476
5PSkX 496 9,41517
5Pvg2 496 9,37133
5Q9MA 494 9,23995
5QxqI 473 9,25594
5R4mY 477 8,44241
5RVXJ 476 8,10260
5RXe7 481 8,50862
5TVEl 478 7,59400
5U5JC 485 7,95877
5Ugnt 476 6,94154
5V5BE 546 8,27195
5VTC5 502 9,36914
5VcMe 485 7,46548
5VfJh 496 9,44276
5VikE 481 8,18873
5WCFx 497 9,27102
5WPDr 447 8,83586
5WUO2 473 9,22750
5Wwzd 496 9,36450
5XGJu 485 7,46730
5YC9Q 491 9,40054
5YEI7 443 7,61872
5YFs3 473 9,26200
5Yuct 496 9,37133
60G1f 508 9,33807
60WS3 485 8,92483
61ErH 477 8,57199
61KSo 490 9,37133
61Nlo 481 8,53395
61aa4 500 6,18871
61my0 491 9,39680
61tzw 492 9,00825
62CoF 484 9,13351
62KBV 496 9,34729
62a3d 473 9,18089
62zFJ 496 9,44276
630ap 491 9,39345
639u9 484 8,52190
64XY2 486 9,31293
667OZ 477 8,13212
66l4G 478 9,41885
67G4I 426 7,18555
67Kkk 367 8,56226
68yOg 481 7,64544
6969p 479 9,29307
69HtC 479 9,17329
69JGR 477 7,46594
69O43 478 8,58888
6YJ5d 496 9,39358
6aSDm 496 9,25781
6anND 473 9,22164
6bVNx 502 9,35709
6bmuw 490 9,19714
6bsyS 498 9,23266
6c27c 490 7,50067
6c3Xo 380 8,20201
6cFHl 491 9,40763
6cVmq 508 9,41008
6cWIm 477 8,13219
6csME 477 8,30709
6cynb 473 9,23356
6dXRa 497 9,28643
6eJbz 447 8,51713
6evjJ 496 9,33330
6fTov 473 9,29346
6fiXj 490 9,27508
6g2Lo 491 9,39300
6iFfm 485 6,95274
6jmsS 477 8,87873
6lGrn 489 7,50527
6lSMp 477 8,44241
6lyGg 487 9,45669
6mKuX 476 7,45076
6mL8g 484 8,21335
6n8lD 476 9,26799
6oi9C 593 9,19211
6pI8i 473 9,09193
6pKWI 420 8,74496
6pWfF 478 8,60461
6rFRL 496 9,33336
6rh5M 487 8,78138
6rvj6 503 9,55230
6sYV7 490 8,80047
6tDgr 494 9,32846
6tK56 593 9,28237
6tjXN 484 7,08029
6uyOw 473 9,26019
6v1Yi 415 6,98474
6wIRB 485 9,54005
6wuKH 496 9,31396
6wxg2 490 9,11288
70ort 496 9,34729
7JITj 424 5,18431
7M6Nn 485 8,16481
7Umes 491 9,37823
7XSY1 472 9,33143
7YCHV 469 7,86574
7ZE4N 484 6,29557
7uoCB 598 9,24285
81mfx 477 9,02314
84x3w 490 9,20307
86uyt 491 9,26412
8dbvA 484 8,51803
8eUJc 491 9,40763
8fenY 485 7,95548
8jR7Y 441 8,44608
8l4P7 485 8,38194
8loNv 433 6,43391
8n7Rz 469 8,13896
8pG6l 474 8,42384
8pvUQ 469 7,02072
8qVdt 473 9,18418
BB1m 491 9,33994
CUSM 481 7,51056
F6wb 478 9,15685
HFxE 477 8,80975
MTyD 484 8,63717
ORWN 496 9,40782
OwHA 508 9,35863
OxwJ 447 8,80956
b2rB 477 8,74593
oFiw 477 8,91651
x2pg 479 8,66141
xiS4 491 9,40041
zaJX 473 9,28495
A0A8S5SU94 574 9,33401
A0A8S5U8K0 484 8,21535
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_16417
6gC98
 231 41,1% 394 3.261E-111
2 phalp2_34762
3ij83
 364 35,7% 445 3.134E-97
3 phalp2_4916
6k3vw
 208 29,5% 528 6.924E-74
4 phalp2_2377
7JCYq
 91 26,0% 503 3.181E-73
5 phalp2_1872
3VMqM
 12 25,2% 543 4.681E-50
6 phalp2_34377
4dm6y
 15 23,3% 569 3.544E-45
7 phalp2_24001
41ivD
 4 26,1% 444 6.384E-45
8 phalp2_17564
66E2C
 6 23,0% 439 5.791E-40
9 phalp2_14277
3nL7u
 72 28,2% 386 4.436E-39
10 phalp2_1509
21BcC
 2 22,4% 530 4.604E-33

Domains

Domains [InterPro]
Unannotated
Unannotated
GH25
Unannotated
Unannotated
Representative sequence (used for alignment): 3tdUS (604 AA)
Member sequence: A0A8S5QAY3 (447 AA)
1 604 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctqBH20
[NCBI] 		2825680 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015626 [NCBI]
CDS location
range 39765 -> 41108
strand +
CDS
ATGGAAATCAAAGGAATTGATGTATCTGCTTACCAGGGAAAGATTGACTGGGAAACAGTGGCAGATTATGGAATGGGATTTGCAATCCTGCGGATCACGGAAAAGGGAAATAAAACAGACAGTACCTTTGAGCAGAACTACAAGGGCTGTACTCAGCATGGAATCCCGGTTGGGGTGTACAAATACAGCTATGCCAAAAGCCCGGCACAGGCAGAACAGGAAGCGGAGAGTGTACTGAAAGTCCTGAACAAGCGCCGGCTTAATTTCCCCGTCTTTCTCGATTTAGAGTGGTCTGAACAAAGGAAGCTTGGAAGCGCAGCAGTGGAAAAGATTGCCCTGGCATTTTTAAATAAAACTCAGGCAGCAGGATATCAGGGCGGGATCTACTGCAACCTGGACTGGTATCAGAATGTATTGACAAAAGCTTTAAAAAAATATGACTGCTGGATTGCCAGATATCCGGCCAATGACAACGGAACGCTGCAGGAACGTCTCCGGCCGGAGGTAGGAGTGGGCTGGCAGTATTCCAGTAAAGCAACGATTCCGGGAATTGGAACAAAGGTTGACCGGAATGTATTTTATAAAAATTACACAGAAGGGGAAGGAGAACCTATGAGCAAGATAGAAAAAGCAGTACAGCAGATGGAAACATGGGCGAAAGACAATTCCCATGGATATGATCAGATCTACAGATGGGGAGAGAAGGGAGACTATGATTGTTCAGCGGCAGTCATTCAGGCTTGCCAGAACGCCGGGATTCCGGTCAAGACAGGCGGAGCGACTTATACAGGAAACATGCTCAAGGTCTTCACAAAAAATGGTTTTGAGGTCATCACTCATGAGGTAAATCTCAAGACTGGAGCAGGACTGGTTCGTGGAGACGTGCTTCTGAATACGTCTCACCATACCGCTATGTATTGCGGCAACGGAAAAGAAGTTGAAGCATCTATCAACGAAAAAGGAACTGCCACAGGCGGCAAACCGGGCGATCAGACCGGAAGAGAGTTCCTGATCCGAAGCTATAGAAATTATCCTTGGACACATGTACTTAGATACACAAAAGATGGTACAACTGGAAATACCGATACACAGACAGGAGGTCATTATATGTTTGAGCCGAAAACAGTAAAAAAGGGAGACAACGGATTATCTGTATTACTGCTTCAGGAGATTTTAATCGCCAGAGGATTTAAAGGTAAGGACGGCAAGCCTCTTACCCTGGACAGAGCAGCAGGTACCAATACGATCCACGCACTTACCCAGTACCAGAAGAGCCGCAAGGGTGTCCTGGAAGCAGATGGTATCTGTGGTGATAAGACCTGGAGAGATCTGATTGCTTTGTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (3tdUS) rather than this protein.
PDB ID
3tdUS
Method AlphaFoldv2
Resolution 80.25
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50