Protein

Protein accession
A0A8S5QAI4 [UniProt]
Representative
3kLGA
Source
UniProt (cluster: phalp2_14273)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 96% (predicted by ML model)
Protein sequence
MSKLFGIDTSRWQGDFDFKGAKDNEGVDFAIIKAGGADDGLYEDREFENSYNKLENAGIHKGAYFFGNALSTDEAVNEARYFAQLLAGKSFCYPVFYDVEAGMVTGNDLTDIIMAFLDEMRNAGYKNVGLYSYENCINNYVDISRVKEAGYAVWVARYSDIEPRIAVDYDMWQFGGSVNYLRDTQINGQTVDQNYCYTDYCTDHIVEEVTVPDYEPVPDTKYHKGDTVKVINAIQYDNGEPFGTYYDEYSVLSANGRRVVIGIGGVTTAAIDEDNISLIKCIYDNDNDINTDTVSRGDGKKVRVLDNIDYDGARFAVYYDEYDVIEESGDRIVIGIGTAITAAVNIANLEFVGGSDDTPTDIPFSEDIEEGNTVRFVGNTDYDGTAIKAWFDEYTVSERSGDRVVLVHDGELFAAVNVADCELV
Physico‐chemical
properties
protein length:424 AA
molecular weight:47197,2 Da
isoelectric point:4,15
hydropathy:-0,33
Representative Protein Details
Accession
3kLGA
Protein name
3kLGA
Sequence length
228 AA
Molecular weight
25931,63690 Da
Isoelectric point
9,22248
Sequence
MSQKFGIDVSHWQGDFNFARAKSNEGVEFAILKAGGGDAGLYKDSKFEANYEKCEDCGLPKGAYFYGNAKSVAEAKKEAEYFISILSGKKYEYPVFYDVEGKMITDNDRATLTEIVKAFCSTMEAAGYWVGIYSSESFFNSEMNDGELTRYSHWVARWGKSKLLPVVQKHRCGSLAVKLICFVVIKSMVKPAIRIIAMWIILLRLKRQDSMAIQKARHQNQRLQRKLQ
Other Proteins in cluster: phalp2_14273
Total (incl. this protein): 7 Avg length: 333,4 Avg pI: 5,68
Protein ID Length (AA) pI
3kLGA 228 9,22248
1jG1D 319 7,52397
5LZmX 195 5,19312
A0A8D9UIG0 426 4,15609
A0A8S5R5Y0 426 4,11608
A0A8S5SEY5 316 5,36039
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_31512
3WNwM
 280 53,0% 166 1.670E-54
2 phalp2_3425
3TK4D
 923 48,1% 158 4.260E-48
3 phalp2_11218
6q99m
 1 46,7% 156 7.765E-42
4 phalp2_24879
a1g4
 16 44,2% 149 1.587E-39
5 phalp2_6199
5X5xO
 102 41,2% 172 4.057E-39
6 phalp2_4390
2mvmf
 118 45,7% 140 2.561E-35
7 phalp2_5668
4yhqW
 7 32,5% 166 7.414E-26
8 phalp2_13529
7Jyqc
 660 37,1% 167 3.049E-24
9 phalp2_24174
2ojoF
 57 36,0% 161 1.432E-23
10 phalp2_10753
3yWC4
 1 34,7% 144 5.041E-21

Domains

Domains [InterPro]
GH25
Representative sequence (used for alignment): 3kLGA (228 AA)
Member sequence: A0A8S5QAI4 (424 AA)
1 228 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctu9a31
[NCBI] 		2825712 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015613 [NCBI]
CDS location
range 28781 -> 30055
strand +
CDS
ATGAGTAAATTATTCGGAATTGACACATCAAGATGGCAGGGAGACTTTGATTTCAAGGGTGCAAAGGATAATGAGGGTGTAGACTTTGCAATCATCAAAGCGGGCGGTGCTGATGATGGCTTATACGAAGATAGAGAATTTGAGAACAGCTATAACAAGTTGGAAAATGCAGGAATCCACAAAGGAGCCTATTTCTTTGGTAACGCATTAAGCACTGATGAAGCTGTAAATGAAGCCAGATATTTCGCACAGCTTTTAGCAGGCAAATCATTCTGCTATCCAGTGTTCTATGATGTTGAAGCAGGCATGGTTACTGGCAATGACCTTACAGACATCATTATGGCATTCCTTGATGAAATGAGAAACGCAGGCTATAAGAATGTTGGTTTATACTCATATGAGAACTGCATTAACAATTATGTAGATATTTCGAGAGTAAAAGAAGCTGGTTATGCCGTTTGGGTTGCAAGATATTCAGATATAGAGCCAAGAATCGCTGTTGATTATGATATGTGGCAGTTCGGCGGAAGCGTTAATTATCTTAGAGACACGCAGATTAACGGTCAGACAGTAGACCAGAACTATTGCTATACTGATTATTGTACAGACCATATTGTCGAAGAAGTTACAGTGCCAGACTATGAGCCAGTGCCAGACACTAAGTATCATAAAGGCGATACAGTTAAGGTTATTAACGCTATCCAGTACGATAATGGAGAGCCATTCGGTACTTACTATGACGAGTACAGCGTCTTATCTGCTAATGGCAGAAGAGTTGTTATCGGCATTGGCGGCGTAACTACTGCTGCTATTGATGAGGATAACATCAGCCTTATTAAGTGCATTTATGACAACGACAATGATATCAACACAGATACAGTAAGTCGTGGCGACGGCAAGAAAGTCAGAGTGCTTGATAACATTGATTATGACGGTGCAAGATTTGCGGTATATTATGATGAATATGATGTGATTGAAGAGAGTGGGGATAGAATTGTTATAGGTATCGGCACAGCAATCACAGCCGCAGTAAATATTGCTAACCTTGAATTTGTTGGCGGTTCTGATGATACACCTACAGATATCCCGTTCAGTGAAGATATTGAAGAGGGCAACACAGTAAGATTTGTCGGAAACACAGATTATGACGGCACAGCTATTAAGGCTTGGTTTGATGAATACACAGTATCAGAAAGAAGCGGAGACAGAGTTGTGCTTGTACATGACGGAGAGTTATTCGCAGCGGTCAATGTAGCTGATTGTGAATTAGTCTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (3kLGA) rather than this protein.
PDB ID
3kLGA
Method AlphaFoldv2
Resolution 78.14
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50